STAT3 Gene Hyper-IgE recurrent infection syndrome NGS Genetic Test
Short Name: STAT3 Hyper-IgE Syndrome NGS Test
Also known as: Job syndrome, Buckley syndrome, STAT3 deficiency
STAT3 Gene Hyper-IgE recurrent infection syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to diagnose STAT3 Gene Hyper-IgE Recurrent Infection Syndrome by detecting mutations in the STAT3 gene using NGS technology. It helps confirm clinical suspicion, guide treatment decisions, and provide genetic counseling for families.
- Test Code
- 4966
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
Clinical history of the patient and a genetic counseling session to draw a pedigree chart of affected family members are required before sample collection.
Method: Venipuncture
Laboratory Analysis
Standard venipuncture procedure to collect blood sample. For FTA card, a drop of blood is applied.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Store sample as per instructions.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to diagnose STAT3 Gene Hyper-IgE Recurrent Infection Syndrome by detecting mutations in the STAT3 gene using NGS technology. It helps confirm clinical suspicion, guide treatment decisions, and provide genetic counseling for families.
How to Prepare
- Provide detailed clinical history
- Attend genetic counseling session
- Ensure sample is collected in a sterile environment
- Label sample correctly with patient details
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This NGS test is essential for confirming Hyper-IgE syndrome, which can cause severe recurrent infections and complications. Early diagnosis aids in management and genetic counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient sample volume
- Incorrect labeling
- Contaminated sample
Understanding Your Results
Positive for pathogenic variant
Confirms diagnosis of STAT3 Hyper-IgE syndrome. Genetic counseling and management recommended.
Negative for pathogenic variant
No mutations detected. Clinical correlation and additional tests may be needed if symptoms persist.
Variant of uncertain significance
Further evaluation and family studies recommended.
Consult a doctor if you experience recurrent infections, chronic eczema, or have a family history of Hyper-IgE syndrome. After testing, consult for result interpretation and management.
Limitations
- ⚠May not detect all genetic variants
- ⚠Requires genetic counseling for interpretation
- ⚠Not a standalone diagnostic tool; clinical correlation is essential
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Emotional impact of genetic results
Interfering Factors
- ●Sample contamination
- ●Improper sample storage
- ●Recent blood transfusion
Frequently Asked Questions
What is STAT3 Gene Hyper-IgE Recurrent Infection Syndrome?
What are the common symptoms of this syndrome?
How is the NGS Genetic Test performed?
What is the cost of the test?
Is home sample collection available?
How long does it take to get results?
What does a positive test result mean?
Is genetic counseling required before the test?
Can this test be done for children?
What are the risks associated with the test?
How accurate is the NGS test for this syndrome?
What should I do if I test positive?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
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