STX11 Gene Hemophagocytic lymphohistiocytosis type 4 NGS Genetic Test
Short Name: STX11 HLH Type 4 NGS Test
Also known as: HLH Type 4 Genetic Test, STX11 Mutation Analysis, Familial HLH Type 4 NGS Test
STX11 Gene Hemophagocytic lymphohistiocytosis type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the STX11 Gene HLH Type 4 NGS Genetic Test is to identify pathogenic mutations in the STX11 gene, confirming a diagnosis of Hemophagocytic Lymphohistiocytosis Type 4. This enables precise clinical management, genetic counseling for affected families, and informed treatment decisions to mitigate disease progression.
- Test Code
- 4960
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
Clinical history of the patient, including symptoms and family history of HLH, must be documented. A genetic counseling session is recommended to draw a pedigree chart of affected family members.
Method: Venipuncture
Laboratory Analysis
Blood sample is collected via venipuncture into an EDTA tube or as a drop on an FTA card. Standard aseptic techniques are followed to ensure sample integrity.
Report Delivery
Sample is labeled, stored at ambient room temperature, and transported to the laboratory for processing. Patients may resume normal activities immediately after blood draw.
Timeline: 3 to 4 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the STX11 Gene HLH Type 4 NGS Genetic Test is to identify pathogenic mutations in the STX11 gene, confirming a diagnosis of Hemophagocytic Lymphohistiocytosis Type 4. This enables precise clinical management, genetic counseling for affected families, and informed treatment decisions to mitigate disease progression.
How to Prepare
- Fast for 4-6 hours if specified, though not required for this test
- Avoid strenuous exercise before sample collection
- Inform the phlebotomist of any medications or recent transfusions
- Ensure proper identification and labeling of the sample
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for STX11 mutations is essential for confirming Hemophagocytic Lymphohistiocytosis Type 4, enabling targeted treatment and family counseling to improve patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Improper labeling or documentation
- Samples collected in incorrect containers
Understanding Your Results
Consult a doctor if you experience symptoms such as persistent fever, enlarged spleen, unexplained low blood counts, or neurological issues, especially with a family history of HLH. Early consultation can facilitate timely genetic testing and treatment.
Limitations
- ⚠May not detect all possible STX11 mutations or variants of uncertain significance
- ⚠Results require correlation with clinical findings and family history
- ⚠Genetic counseling is recommended for interpretation
- ⚠Does not rule out other causes of HLH
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection at the puncture site
- ●Psychological impact of genetic results; counseling support available
Interfering Factors
- ●Poor sample quality (e.g., hemolyzed blood)
- ●Contamination during sample collection or transport
- ●Insufficient DNA quantity
- ●Recent blood transfusions may affect results
Compare With Similar Tests
| Test | STX11 Gene Hemophagocytic lymphohistiocytosis type 4 NGS Genetic Test | PRF1 Gene HLH Type 2 NGS Test | UNC13D Gene HLH Type 3 NGS Test | RAB27A Gene HLH Type 5 NGS Test | Comprehensive HLH Gene Panel |
|---|---|---|---|---|---|
| Comparison | STX11 Gene Hemophagocytic lymphohistiocytosis type 4 NGS Genetic Test |
Frequently Asked Questions
What is Hemophagocytic Lymphohistiocytosis (HLH)?
What causes HLH Type 4?
How is the STX11 Gene HLH Type 4 NGS Genetic Test performed?
Who should get this genetic test?
What is the cost of the STX11 Gene HLH Type 4 NGS Genetic Test in India?
Is the test covered by insurance?
How long does it take to get results?
What do the test results mean?
Is genetic counseling required before testing?
What are the risks of the test?
Can this test be done at home?
What should I do if I test positive for an STX11 mutation?
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