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DNA Labs India

Syphilis Comprehensive Panel Test

DNA Labs India | ISO 9001:2015 Certified

Syphilis Comprehensive Panel Test

Short Name: Syphilis Comprehensive Panel

Also known as: Syphilis Panel, Syphilis Serology Panel, VDRL/TPHA/FTA-ABS Panel

Syphilis Comprehensive Panel Test test available at DNA Labs India for ₹4,000. Uses Charcoal Flocculation, Hemagglutination, Indirect Immunofluorescence Assay on Serum samples. Results in Samples are processed on Tuesday, Thursday and Saturday. Reports are available on the same day via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.

Physician, GynecologistAdults and Adolescents🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Kothari Ramesh Shantilal

Dr Kothari Ramesh Shantilal

Consultant Microbiologist · Reg: 27670

Last reviewed: September 7, 2026

Overview

The purpose of this panel is to detect antibodies against Treponema pallidum and support the diagnosis of syphilis. It combines screening and confirmatory tests to reduce the chance of false-positive results and to guide clinical decisions.

Test Code
3675
Price
₹4,000
Sample Type
Serum
Result Time
Samples are processed on Tuesday, Thursday and Saturday. Reports are available on the same day via online portal, email, or WhatsApp.
Fasting Required
No
Method
Charcoal Flocculation, Hemagglutination, Indirect Immunofluorescence Assay
Step 1

Sample Collection

No special preparation required. Inform the laboratory if you have recently taken antibiotics or have a known medical condition such as pregnancy or autoimmune disease.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample is collected from a vein in your arm. The procedure takes only a few minutes.

Step 3

Report Delivery

You may resume your routine immediately after collection. Keep the puncture site clean and press cotton over it for a couple of minutes.

Timeline: Samples are processed on Tuesday, Thursday and Saturday. Reports are available on the same day via online portal, email, or WhatsApp.

Patient Instructions

1
Before the Test:No special preparation required. Tell your doctor about any current medicines, antibiotic use, pregnancy, or health conditions.
2
During the Test:A small amount of blood is drawn from a vein. The process takes only a few minutes.
3
After the Test:You can go back to your routine immediately. If you feel dizzy, sit for a few minutes before leaving.

About This Test

Who Should Get This Test

The purpose of this panel is to detect antibodies against Treponema pallidum and support the diagnosis of syphilis. It combines screening and confirmatory tests to reduce the chance of false-positive results and to guide clinical decisions.

How to Prepare

  • Fasting is not required.
  • Carry a valid doctor's prescription if available.
  • Inform the lab about recent antibiotic use or other clinical conditions.
  • Keep your booking ID ready for home sample collection.

Doctor's Notes

Reviewed by — MBBS, MD (Microbiology) · Reg. No. 27670

"A single positive non-treponemal test should not be used alone to diagnose syphilis. The comprehensive panel gives higher diagnostic confidence before starting treatment. Early syphilis is curable, and treatment is safe even in pregnancy."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume3 mL (1 mL min.) serum
ContainerSST (Serum Separator Tube)
Collection MethodVenipuncture

Sample Stability

Room Temperature
Refrigerated (2-8°C)
Frozen (-20°C)
Sample Rejection Criteria:
  • Hemolysed or visibly damaged serum samples
  • Samples with insufficient quantity (minimum 1 mL serum)
  • Incorrectly labelled or unlabelled samples
  • Samples received after the cut-off time for same-day processing

Understanding Your Results

This panel includes one non-treponemal test (VDRL/RPR) and two treponemal tests (TPHA and FTA-ABS). Results should be interpreted by a qualified doctor in the context of your history, symptoms, and risk factors.
📊

VDRL/RPR non-reactive, TPHA non-reactive, FTA-ABS non-reactive

No serological evidence of syphilis infection.

📊

VDRL/RPR reactive, TPHA reactive, FTA-ABS reactive

Serologically consistent with current or past syphilis. Clinical correlation and treatment decisions should be made by a doctor.

📊

VDRL/RPR reactive, TPHA non-reactive, FTA-ABS non-reactive

Suggests a possible false-positive VDRL/RPR; repeat testing and clinical correlation are needed.

📊

VDRL/RPR non-reactive, TPHA reactive, FTA-ABS reactive

May represent treated past syphilis or late syphilis. FTA-ABS can remain positive for life.

⚠️ When to Consult a Doctor:

If your syphilis panel result is reactive, consult a doctor or infectious disease specialist as soon as possible. Early treatment with antibiotics is highly effective. Sexual partners should also be tested and treated to prevent reinfection and further spread.

Limitations

  • ⚠Serological tests cannot always distinguish between active and past treated syphilis.
  • ⚠TPHA and FTA-ABS often remain reactive for life after infection, so they are not used to monitor treatment response.
  • ⚠A negative result during the window period does not exclude early syphilis; repeat testing may be required.

Risks & Considerations

  • ●Mild pain or discomfort at the needle site
  • ●Small bruise or bleeding
  • ●Rare risk of infection at the puncture site

Interfering Factors

  • ●Recent antibiotic therapy may suppress antibody production and cause false-negative results.
  • ●Testing during the window period before antibodies develop may produce a negative result.
  • ●Biological false-positive VDRL/RPR can occur in pregnancy, autoimmune diseases, HIV infection, and some other infections.

Frequently Asked Questions

What is the Syphilis Comprehensive Panel test?
It is a blood test that combines three serological tests — VDRL/RPR, TPHA, and FTA-ABS — to detect exposure to Treponema pallidum, the bacterium that causes syphilis. A doctor uses it to screen, diagnose, or confirm syphilis infection.
What is included in the panel?
The panel includes a non-treponemal screening test (VDRL/RPR) and two treponemal tests (TPHA and FTA-ABS). The combination provides better diagnostic confidence than any single test.
Do I need to fast for the test?
No, the Syphilis Comprehensive Panel test does not require fasting. You can eat and drink normally before sample collection.
How much does the test cost?
The test cost is INR 4000 at DNA Labs India. Free home sample collection is available for online bookings in selected cities.
How is the sample collected?
A trained phlebotomist draws approximately 3 mL of blood from a vein in your arm. The blood is collected in a serum separator tube and sent to the laboratory.
When will I get the report?
Samples are scheduled on Tuesday, Thursday, and Saturday, with samples received by 9 am. Reports are usually ready the same day and can be accessed online, by email, or on WhatsApp.
What does a non-reactive result mean?
A non-reactive result means no antibodies were detected with the methods used. However, negative results do not fully rule out early syphilis because the body may take 2 to 4 weeks to develop antibodies.
What does a reactive result mean?
A reactive result indicates the presence of antibodies against syphilis. It may suggest current or past infection. Additional clinical correlation and sometimes follow-up testing are needed to decide the treatment.
Can the test produce false-positive or false-negative results?
Yes. False-positive VDRL/RPR can occur in pregnancy, autoimmune diseases, and some infections. False-negative can occur in very early infection or if antibiotics were given too early. Confirmatory tests help reduce errors.
Is home sample collection available?
Yes, DNA Labs India provides free home sample collection for the Syphilis Comprehensive Panel test when booked online. The service is available in many cities across India.
Is this test needed during pregnancy?
Screening for syphilis is recommended during pregnancy because untreated syphilis can be transmitted to the baby and cause congenital syphilis, stillbirth, or severe complications. If infected, treatment can protect both mother and baby.
How soon after exposure should I get tested?
Testing before the window period may be negative. For syphilis, the window period is usually 2 to 4 weeks, but it can be longer. If you have had a sexual exposure, contact your doctor about the right time to test and whether repeat testing is needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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