Systemic Sclerosis Profile IgG Test
Short Name: SSc Profile IgG
Also known as: Scleroderma
Systemic Sclerosis Profile IgG Test test available at DNA Labs India for ₹16,500. Uses Immunoblot on Serum samples. Results in Results are typically available on the same day if the sample is received by 11 am, with reports delivered by 6 pm.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Systemic Sclerosis Profile IgG test is to detect specific IgG antibodies in the blood that are commonly associated with systemic sclerosis (scleroderma). This test helps confirm a diagnosis when clinical symptoms such as skin thickening, Raynaud's phenomenon, joint pain, or internal organ involvement are present. By identifying antibodies like Scl-70, CENP A, CENP B, and RNA polymerase III, it differentiates systemic sclerosis from other autoimmune conditions. Early and accurate diagnosis enables timely treatment, which can manage symptoms, slow disease progression, and reduce the risk of complications like pulmonary fibrosis or renal crisis. The test is often ordered by rheumatologists or immunologists as part of a comprehensive evaluation for autoimmune disorders.
- Test Code
- 1424
- Price
- ₹16,500
- Sample Type
- Serum
- Result Time
- Results are typically available on the same day if the sample is received by 11 am, with reports delivered by 6 pm.
- Fasting Required
- No
- Method
- Immunoblot
Sample Collection
No special preparation such as fasting is required. Inform your healthcare provider about any medications or supplements you are taking.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist. The process typically takes a few minutes.
Report Delivery
Apply pressure to the puncture site to prevent bruising. You can resume normal activities immediately.
Timeline: Results are typically available on the same day if the sample is received by 11 am, with reports delivered by 6 pm.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Systemic Sclerosis Profile IgG test is to detect specific IgG antibodies in the blood that are commonly associated with systemic sclerosis (scleroderma). This test helps confirm a diagnosis when clinical symptoms such as skin thickening, Raynaud's phenomenon, joint pain, or internal organ involvement are present. By identifying antibodies like Scl-70, CENP A, CENP B, and RNA polymerase III, it differentiates systemic sclerosis from other autoimmune conditions. Early and accurate diagnosis enables timely treatment, which can manage symptoms, slow disease progression, and reduce the risk of complications like pulmonary fibrosis or renal crisis. The test is often ordered by rheumatologists or immunologists as part of a comprehensive evaluation for autoimmune disorders.
How to Prepare
- Ensure the sample is collected in a sterile environment
- Use a serum separator tube (SST)
- Label the sample correctly with patient details
- Ship the sample refrigerated or frozen as per stability guidelines
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early detection of systemic sclerosis through antibody profiling can lead to timely management and improved patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Hemolyzed, icteric, or lipemic samples
- Improper labeling or container
- Sample received after stability period
Understanding Your Results
Strongly associated with diffuse cutaneous systemic sclerosis and higher risk of pulmonary fibrosis.
Typically linked to limited cutaneous systemic sclerosis and CREST syndrome.
Associated with diffuse scleroderma and increased risk of scleroderma renal crisis.
May be present in various systemic sclerosis subsets or other autoimmune conditions; clinical correlation is essential.
Consult a rheumatologist or immunologist if you experience symptoms like skin thickening, Raynaud's phenomenon, joint pain, or organ-related issues, especially if the test results are positive or inconclusive. Early consultation can facilitate appropriate management.
Limitations
- ⚠This test detects IgG antibodies only; other antibody classes may be missed
- ⚠False positives can occur in other autoimmune conditions
- ⚠Results should be correlated with clinical findings and other tests
Risks & Considerations
- ●Minor bruising or soreness at the needle site
- ●Rare risk of infection or excessive bleeding
- ●Faintness during blood draw
Interfering Factors
- ●Hemolyzed or lipemic samples may affect results
- ●Recent blood transfusions could interfere
- ●Immunosuppressive medications might reduce antibody levels
Frequently Asked Questions
What is the Systemic Sclerosis Profile IgG Test?
Why is this test recommended?
What does a positive result mean?
How much does the test cost in India?
Is home sample collection available?
What is the turnaround time for results?
Do I need to fast before the test?
What sample type is needed?
Are there any risks associated with the test?
What other tests might be ordered along with this?
Can this test be used to monitor treatment?
How accurate is the test?
Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.