TARDBP Gene Amyotrophic Lateral Sclerosis Type 10 NGS Genetic Test
Short Name: TARDBP NGS Test
Also known as: TARDBP Gene Mutation Test, ALS Type 10 Genetic Test, TDP-43 Gene Sequencing, TARDBP Gene Analysis
TARDBP Gene Amyotrophic Lateral Sclerosis Type 10 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The NGS run, data analysis, Sanger confirmation (if required) and report preparation usually take 3 to 4 weeks from the date the sample is received by the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of this NGS genetic test is to detect sequence variants in the TARDBP gene that are associated with Amyotrophic Lateral Sclerosis Type 10 (ALS10). The test helps in confirming a clinical diagnosis, identifying presymptomatic family members, facilitating reproductive decision-making, and guiding disease management. It is not intended for unrelated genetic screening.
- Test Code
- 3874
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- The NGS run, data analysis, Sanger confirmation (if required) and report preparation usually take 3 to 4 weeks from the date the sample is received by the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation or fasting is required. The patient should bring a doctor’s prescription, previous medical records, and any prior genetic test results if available. A genetic counselling session is recommended to draw a pedigree chart before the test.
Method: Blood draw or FTA card spot
Laboratory Analysis
The sample is collected either by a venipuncture from the arm or by a simple heel/finger prick for the FTA card, depending on the method chosen. The procedure takes under 5 minutes.
Report Delivery
No post-test restrictions. Patients may resume their usual activities immediately. The sample is securely transported to the laboratory for DNA extraction and testing.
Timeline: The NGS run, data analysis, Sanger confirmation (if required) and report preparation usually take 3 to 4 weeks from the date the sample is received by the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this NGS genetic test is to detect sequence variants in the TARDBP gene that are associated with Amyotrophic Lateral Sclerosis Type 10 (ALS10). The test helps in confirming a clinical diagnosis, identifying presymptomatic family members, facilitating reproductive decision-making, and guiding disease management. It is not intended for unrelated genetic screening.
How to Prepare
- For blood collection, use an EDTA vacutainer.
- For FTA card, apply one drop of blood directly onto the card and allow it to dry completely before sealing.
- Label the sample tube or FTA card with the patient’s full name, date of birth and date of collection.
- Transport the sample at room temperature, but avoid excessive heat or direct sunlight.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Patients with suspected hereditary neurological conditions should receive genetic counselling before and after testing to fully understand the implications of results for themselves and their family members."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or haemolysed blood sample
- Insufficient sample volume
- Improperly labelled specimen
- Sample received after prolonged transit at extreme temperatures
- Expired collection tube or damaged FTA card
Understanding Your Results
No pathogenic variant detected
No disease-causing mutation was identified in the TARDBP gene. This does not rule out ALS caused by other genes or non-genetic factors.
Pathogenic variant detected
A variant known to cause ALS Type 10 was found. This confirms the genetic diagnosis and has implications for family members.
Variant of uncertain significance (VUS) detected
A DNA change was found, but its role in the disease is unclear. Additional testing of family members may help clarify its significance.
If the test result is positive for a pathogenic TARDBP mutation, please consult a neurologist and a clinical geneticist for management planning, family screening and genetic counselling. If a VUS is reported, a genetic counsellor should be consulted to discuss options.
Limitations
- ⚠This test is limited to mutations in the TARDBP gene and does not rule out other genetic causes of ALS.
- ⚠NGS may not detect large deletions/duplications, deeply intronic variants, or some structural rearrangements.
- ⚠Normal result does not exclude a non-genetic cause of ALS.
- ⚠Variant of uncertain significance (VUS) may require further familial segregation studies.
Risks & Considerations
- ●A simple blood draw may cause slight bruising, mild pain, or in rare cases infection at the puncture site.
- ●Genetic testing can reveal mutations that may cause psychological stress or affect family dynamics.
- ●A VUS result may lead to uncertainty and require further testing.
Interfering Factors
- ●Poor quality or degraded DNA sample
- ●Contamination of sample with foreign DNA
- ●Incomplete clinical or family history that may affect interpretation
- ●Recent allogeneic bone marrow transplantation may affect DNA test results
Compare With Similar Tests
| Test | TARDBP Gene Amyotrophic Lateral Sclerosis Type 10 NGS Genetic Test | TARDBP Gene NGS Test | SOD1 Gene NGS Test | C9orf72 Repeat Expansion Test |
|---|---|---|---|---|
| Comparison | TARDBP Gene Amyotrophic Lateral Sclerosis Type 10 NGS Genetic Test |
Frequently Asked Questions
What is the TARDBP gene?
What is ALS Type 10?
Who should consider this test?
What is the cost of the TARDBP gene test at DNA Labs India?
What is the sample requirement for the test?
How long does it take to get the report?
Is fasting required for this test?
Can this test detect all genetic causes of ALS?
What do the different result types mean?
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