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TGM6 Gene Spinocerebellar ataxia type 35, autosomal dominant NGS Genetic Test

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TGM6 Gene Spinocerebellar ataxia type 35, autosomal dominant NGS Genetic Test

Short Name: SCA35 NGS Genetic Test

Also known as: SCA35 Genetic Test, TGM6 Mutation Analysis, Spinocerebellar Ataxia Type 35 DNA Test

TGM6 Gene Spinocerebellar ataxia type 35, autosomal dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to confirm the presence of TGM6 gene mutations associated with Spinocerebellar ataxia type 35 (SCA35) for accurate diagnosis, family risk assessment, and personalized medical management.

Test Code
4577
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No special preparation required. Provide clinical history and family pedigree during genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample via venipuncture from a vein in the arm.

Step 3

Report Delivery

Apply pressure to the puncture site with a cotton ball to stop bleeding. Avoid strenuous activity for a few hours.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss symptoms, family history, and test implications.
2
During the Test:Blood sample collection followed by NGS analysis in the laboratory.
3
After the Test:Receive the report via online portal, email, or WhatsApp, and review results with a healthcare provider.

About This Test

Who Should Get This Test

The purpose of this test is to confirm the presence of TGM6 gene mutations associated with Spinocerebellar ataxia type 35 (SCA35) for accurate diagnosis, family risk assessment, and personalized medical management.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection equipment
  • Label samples correctly
  • Transport samples at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for SCA35 is crucial for accurate diagnosis, family planning, and early management of symptoms."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5-10 mL blood
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Incorrect labeling or container

Understanding Your Results

Results indicate whether a pathogenic TGM6 gene mutation is detected, confirming SCA35 diagnosis.
📊

Positive

Pathogenic variant detected in TGM6 gene, consistent with SCA35 diagnosis. Genetic counseling recommended.

📊

Negative

No pathogenic variant detected in TGM6 gene. Symptoms may be due to other causes; further evaluation advised.

📊

Variant of Uncertain Significance (VUS)

A genetic variant was found but its clinical significance is unknown. Repeat testing or family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a neurologist or geneticist if you experience symptoms of ataxia, have a family history of SCA35, or receive a positive test result for management and counseling.

Limitations

  • ⚠Test only detects mutations in the TGM6 gene; other genetic or non-genetic causes of ataxia are not covered
  • ⚠May not identify all variants of uncertain significance
  • ⚠Results require clinical correlation and genetic counseling

Risks & Considerations

  • ●Minor bruising or pain at the blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Incorrect sample storage

Compare With Similar Tests

TestTGM6 Gene Spinocerebellar ataxia type 35, autosomal dominant NGS Genetic TestSCA Comprehensive PanelWhole Exome SequencingTargeted Mutation Analysis
ComparisonTGM6 Gene Spinocerebellar ataxia type 35, autosomal dominant NGS Genetic Test

Frequently Asked Questions

What is Spinocerebellar ataxia type 35 (SCA35)?
SCA35 is a rare genetic disorder caused by TGM6 gene mutations, leading to progressive problems with movement, coordination, and balance.
What are the common symptoms of SCA35?
Symptoms include loss of coordination, walking difficulties, slurred speech, tremors, impaired fine motor skills, and memory issues, typically starting in mid-adulthood.
How is SCA35 diagnosed?
Diagnosis is confirmed through genetic testing, specifically NGS analysis of the TGM6 gene, as symptoms can overlap with other conditions.
What is NGS genetic testing?
Next-Generation Sequencing (NGS) is a advanced technology that analyzes multiple genes simultaneously to detect mutations, such as in the TGM6 gene for SCA35.
What sample is required for this test?
The test can be performed on a blood sample, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How much does the TGM6 Gene SCA35 NGS test cost in India?
The test costs INR 20000 at DNA Labs India, with free home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
Is genetic counseling included with the test?
Yes, genetic counseling is included to help interpret results and provide guidance on next steps.
Can this test be used for family planning?
Yes, genetic testing can identify carriers and inform family planning decisions through genetic counseling.
What should I do if I receive a positive test result?
Consult a neurologist or geneticist for further evaluation, management options, and family screening.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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