Thrombophilia Profile Test
Short Name: Thrombophilia Profile
Also known as: Thrombophilia Panel, Hypercoagulability Profile, Thrombosis Risk Profile
Thrombophilia Profile Test test available at DNA Labs India for ₹20,000. Uses Chromogenic assay, Immunoturbidimetry, PCR on Whole blood (citrated plasma and EDTA blood) samples. Results in Reports will be delivered as per schedule: samples received by Monday 11 am will be reported on Wednesday, and samples received by Thursday 11 am will be reported on Saturday.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Thrombophilia Profile is to identify genetic or acquired factors that raise the risk for venous thromboembolism. Results help the treating doctor decide how long to continue anticoagulation and whether family members should be screened. It combines functional coagulation assays with molecular tests to give a comprehensive view of thrombotic risk.
- Test Code
- 3695
- Price
- ₹20,000
- Sample Type
- Whole blood (citrated plasma and EDTA blood)
- Result Time
- Reports will be delivered as per schedule: samples received by Monday 11 am will be reported on Wednesday, and samples received by Thursday 11 am will be reported on Saturday.
- Fasting Required
- No
- Method
- Chromogenic assay, Immunoturbidimetry, PCR
Sample Collection
Overnight fasting is preferred. A duly filled Coagulation Requisition Form (Form 15) is mandatory. It is recommended that the patient discontinues Heparin for 1 day and oral anticoagulants for 7 days before sampling, but only with the consent of the treating physician. Do not stop any prescribed medication without medical advice.
Method: Venipuncture
Laboratory Analysis
A phlebotomist will collect 3 mL of whole blood into a Blue Top sodium citrate tube and 5 mL of whole blood into two Lavender Top EDTA tubes. The citrate tube should be mixed gently by inversion to ensure proper anticoagulation.
Report Delivery
The citrate tube must be transported to the laboratory within 4 hours. If this is not possible, platelet-poor plasma should be prepared within 1 hour of collection and frozen immediately. EDTA tubes should be shipped refrigerated, not frozen. Resume prescribed medications only on the treating physician's advice.
Timeline: Reports will be delivered as per schedule: samples received by Monday 11 am will be reported on Wednesday, and samples received by Thursday 11 am will be reported on Saturday.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Thrombophilia Profile is to identify genetic or acquired factors that raise the risk for venous thromboembolism. Results help the treating doctor decide how long to continue anticoagulation and whether family members should be screened. It combines functional coagulation assays with molecular tests to give a comprehensive view of thrombotic risk.
How to Prepare
- Sample type: 3 mL whole blood in 1 Blue Top (Sodium Citrate) tube. Mix thoroughly by inversion.
- Transport to lab within 4 hours.
- If transport is delayed, make platelet-poor plasma (PPP) within 1 hour of collection: centrifuge at 3600 rpm for 15 minutes, transfer supernatant, centrifuge again, transfer to labelled plastic screw-capped vial and freeze immediately. Do not thaw.
- EDTA sample: 5 mL (3 mL minimum) whole blood in 2 Lavender Top (EDTA) tubes. Ship refrigerated. Do not freeze.
- Overnight fasting is preferred and Coagulation Requisition Form (Form 15) must be duly filled.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Thrombophilia testing should be performed when the patient is in a steady state, remote from an acute event, to avoid misleading results caused by acute thrombosis, pregnancy or anticoagulant therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Improper tube fill (underfilled or overfilled citrate tube)
- Citrated whole blood received after 4 hours without PPP preparation
- Thawed frozen plasma
- EDTA sample received frozen
- Missing Coagulation Requisition Form (Form 15)
Understanding Your Results
Inherited thrombophilia with resistance to activated Protein C; increases risk of venous thrombosis.
Inherited thrombophilia with elevated prothrombin level; increases risk of venous thrombosis.
May be inherited or acquired; increases risk of venous thrombosis.
May be inherited or acquired; increases risk of venous thrombosis.
May be inherited or acquired; increases risk of venous thrombosis.
No common inherited thrombophilia identified; further evaluation may be needed based on clinical history.
Seek urgent medical help if you develop swelling, pain, warmth or discolouration in one leg, or chest pain, breathlessness, and coughing blood. If you have a personal or family history of blood clots, discuss whether this test is appropriate with your treating physician.
Limitations
- ⚠Functional assays are unreliable during acute thrombosis or while on anticoagulants.
- ⚠This profile does not include testing for antiphospholipid syndrome or all rare inherited thrombophilias.
- ⚠Genetic tests cover common variants only; a negative result does not exclude all inherited thrombophilic conditions.
- ⚠Reference ranges vary by laboratory, age, sex and clinical state; interpretation should be done by a qualified specialist.
Risks & Considerations
- ●Slight pain or bruising at the venipuncture site
- ●Rare bleeding or hematoma
- ●Dizziness or lightheadedness during blood collection
Interfering Factors
- ●Heparin may lower antithrombin levels.
- ●Warfarin may lower Protein C and Protein S levels.
- ●Acute thrombosis, acute illness, inflammatory conditions, pregnancy and certain medications can alter coagulation protein levels.
- ●Testing during an unstable clinical state may not reflect baseline thrombotic risk.
Compare With Similar Tests
| Test | Thrombophilia Profile Test | |||
|---|---|---|---|---|
| Comparison | Thrombophilia Profile Test |
Frequently Asked Questions
What is the Thrombophilia Profile test?
What does the Thrombophilia Profile test measure?
Who should take this test?
How much does the Thrombophilia Profile Test cost at DNA Labs India?
Is fasting required for this test?
How is the blood sample collected?
Why should anticoagulants be stopped before testing?
When will I get my reports?
Is home sample collection available for this test?
What do abnormal Protein C, Protein S, or Antithrombin levels mean?
Does a negative thrombophilia profile rule out all clotting disorders?
Is this test useful during pregnancy?
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