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TNNT3 Gene Arthrogryposis, distal, type 2B NGS Genetic Test

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TNNT3 Gene Arthrogryposis, distal, type 2B NGS Genetic Test

Short Name: TNNT3 DA2B NGS Test

Also known as: Distal Arthrogryposis Type 2B, DA2B, TNNT3-related arthrogryposis

TNNT3 Gene Arthrogryposis, distal, type 2B NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations in the TNNT3 gene associated with distal arthrogryposis type 2B (DA2B) for accurate diagnosis and genetic counseling.

Test Code
4848
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample will be collected by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session recommended to discuss test implications.
2
During the Test:Sample collection and processing in the laboratory.
3
After the Test:Report generation and delivery via chosen method.

About This Test

Who Should Get This Test

To detect mutations in the TNNT3 gene associated with distal arthrogryposis type 2B (DA2B) for accurate diagnosis and genetic counseling.

How to Prepare

  • Ensure proper identification of patient
  • Use sterile equipment
  • Label samples correctly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for TNNT3 mutations is vital for confirming diagnosis and guiding management in families with arthrogryposis."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the TNNT3 gene.
Positive: Pathogenic variant detected, consistent with DA2B diagnosis
Negative: No pathogenic variants detected, but clinical correlation is needed
Variant of uncertain significance: Further testing or family studies may be required
⚠️ When to Consult a Doctor:

If genetic test results are positive or if symptoms persist, consult a geneticist or orthopedic specialist.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

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Frequently Asked Questions

What is the TNNT3 Gene Arthrogryposis Test?
This test uses Next Generation Sequencing to detect mutations in the TNNT3 gene, which causes distal arthrogryposis type 2B (DA2B), a congenital disorder affecting hands and feet.
Who should get this test?
Individuals with symptoms like joint contractures, clubfoot, camptodactyly, or a family history of DA2B should consider this test for accurate diagnosis.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to identify mutations in the TNNT3 gene.
What is the cost of the test?
The TNNT3 Gene Arthrogryposis Test costs INR 20,000 at DNA Labs India, with home collection available.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks after sample collection.
What do the results mean?
Positive results indicate a pathogenic TNNT3 mutation, confirming DA2B. Negative results suggest no mutations, but clinical correlation is advised.
Is genetic counseling required?
Yes, genetic counseling is recommended before and after testing to understand implications and guide management.
Can this test be used for prenatal diagnosis?
It may be used in prenatal settings if there is a known family history, but consultation with a genetic specialist is essential.
What are the symptoms of DA2B?
Symptoms include contractures of fingers and toes, clubfoot, camptodactyly, hammer toes, and limited range of motion in joints.
How accurate is the NGS test?
NGS is highly accurate for detecting mutations, but it may not identify all types of genetic variations; clinical correlation is important.
What should I do after receiving the results?
Discuss results with a healthcare provider or geneticist for appropriate management, which may include physical therapy or surgical interventions.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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