TRAF3 Gene Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, type 5 NGS Genetic Test
Short Name: TRAF3 NGS Test
Also known as: TRAF3 Encephalopathy, HSV Encephalopathy Susceptibility Type 5, TRAF3 Gene Mutation Analysis, Acute Infection-Induced Encephalopathy Genetic Test
TRAF3 Gene Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, type 5 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are delivered within 3 to 4 weeks from the date the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify pathogenic variants in the TRAF3 gene associated with acute, infection-induced (herpes-specific) encephalopathy susceptibility type 5, providing a molecular diagnosis to guide clinical management and family counseling.
- Test Code
- 4058
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are delivered within 3 to 4 weeks from the date the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended before testing to discuss the purpose, benefits, and implications of this test. The patient should provide a complete clinical history and family history, particularly regarding herpes encephalitis and neurological disorders.
Method: Peripheral blood draw or FTA card blood spot
Laboratory Analysis
A trained phlebotomist will collect a blood sample from a vein in the arm. If using an FTA card, a single drop of blood from a finger prick is placed on the designated filter paper. The collection procedure is quick and typically painless.
Report Delivery
The sample is sent to the DNA Labs India laboratory at ambient temperature. Results are usually available within 3 to 4 weeks. A clinical genetics expert will interpret the findings and provide a comprehensive report. Genetic counseling is available to explain the results and discuss implications for family members.
Timeline: Reports are delivered within 3 to 4 weeks from the date the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
To identify pathogenic variants in the TRAF3 gene associated with acute, infection-induced (herpes-specific) encephalopathy susceptibility type 5, providing a molecular diagnosis to guide clinical management and family counseling.
How to Prepare
- No fasting required for this genetic test
- Blood sample should be collected in an EDTA vacutainer
- If using FTA card, apply one drop of blood to the marked circles and allow to air dry completely
- Label the sample with patient name, date of birth, and collection date
- Do not replace the FTA card in the pouch until the blood spot is completely dry
- Store the sample at room temperature and transport to the laboratory within 5 days
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Timely genetic confirmation for herpes-related encephalopathy susceptibility supports early antiviral prophylaxis and family counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Incorrect anticoagulant tube
- FTA card not fully saturated or contaminated
- Sample leakage or broken container
Understanding Your Results
No pathogenic variant identified
No clinically significant variant was found in the TRAF3 gene. Genetic susceptibility to herpes-specific encephalopathy due to TRAF3 is not supported, but other genes or non-genetic causes should be considered.
Pathogenic variant identified
A disease-causing variant was detected in the TRAF3 gene, confirming the diagnosis of TRAF3-related herpes-specific encephalopathy susceptibility type 5. Management and family screening should be discussed with a specialist.
Likely pathogenic variant identified
A variant likely to cause disease was found. Further family studies or functional analysis may be needed to confirm clinical significance. Clinical correlation is advised.
Variant of uncertain significance (VUS)
A genetic variant was detected whose impact on health is currently unknown. Additional genetic or clinical investigations may help clarify its role.
If you or a family member has a personal history of herpes simplex encephalitis, recurrent unexplained encephalitis, or a suspected genetic immune disorder, consult a neurologist and a clinical geneticist. Early genetic diagnosis can guide preventive antiviral therapy and enable informed reproductive decisions.
Limitations
- ⚠This test only targets the TRAF3 gene and does not evaluate other genes associated with herpes-specific encephalopathy susceptibility, such as TLR3, UNC93B1, or TANK
- ⚠Regulatory regions, deep intronic variants, and large structural rearrangements may not be reliably detected by standard NGS
- ⚠A negative result does not entirely exclude the possibility of TRAF3-related disease if a variant is located in an area not covered by this assay
- ⚠Variant interpretation may require additional family studies or functional validation in some cases
Risks & Considerations
- ●Minor bruising or discomfort at the site where blood is drawn
- ●No significant medical risks associated with genetic testing itself
- ●Possible psychological impact of learning a genetic susceptibility result
Interfering Factors
- ●Recent blood transfusion within 72 hours can dilute patient's genetic material
- ●Sample contamination with another individual's DNA
- ●Insufficient DNA quantity or quality for NGS analysis
- ●Oral antibiotics or antiviral therapy do not directly interfere with DNA testing, but poor clinical sampling may reduce accuracy
Frequently Asked Questions
What is TRAF3 Gene Encephalopathy?
What are the symptoms of TRAF3 Gene Encephalopathy?
How is TRAF3 Gene Encephalopathy diagnosed?
What is the cost of the TRAF3 NGS genetic test in India?
What sample is needed for the TRAF3 NGS test?
Does the TRAF3 genetic test require fasting?
How long does it take to get the TRAF3 NGS test report?
What is the role of NGS in TRAF3 gene testing?
Will this test detect other gene mutations causing encephalopathy?
Can TRAF3 Gene Encephalopathy be prevented with early diagnosis?
Does DNA Labs India provide raw data files with the report?
Why is genetic counseling recommended before this test?
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