Treponema Palladium (Syphilis) (RNA Detection) Qualitative Test
Short Name: Syphilis RNA Qualitative
Also known as: Syphilis RNA PCR, Treponema pallidum RNA Detection, Syphilis Qualitative PCR
Treponema Palladium (Syphilis) (RNA Detection) Qualitative Test test available at DNA Labs India for ₹5,950. Uses Real Time PCR on Urethral or vaginal swab, cell culture, cervical discharge, rectum, urethra, blood, urine samples. Results in Reports are available on the 4th working day. Email reports within 48 hours, phone within 36 hours.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Kothari Ramesh Shantilal
Consultant Microbiologist · Reg: 27670
Last reviewed: September 7, 2026
Overview
The purpose of this test is to qualitatively detect the presence of Treponema pallidum RNA in clinical specimens, confirming active syphilis infection. It is particularly useful in early primary syphilis, congenital syphilis, neurosyphilis, and cases where serological tests are inconclusive. The test also helps in evaluating treatment efficacy by detecting the clearance of the organism.
- Test Code
- 6245
- CPT Code
- 87798
- ICD Code
- A53.9
- Price
- ₹5,950
- Sample Type
- Urethral or vaginal swab, cell culture, cervical discharge, rectum, urethra, blood, urine
- Result Time
- Reports are available on the 4th working day. Email reports within 48 hours, phone within 36 hours.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
No fasting required. Inform your physician about any antibiotics taken in the last 2 weeks. For swab collection, avoid using antiseptic creams or douching before sample collection.
Method: Swab, venipuncture, or urine collection
Laboratory Analysis
For blood sample, a standard venipuncture will be performed. For swab, a sterile swab will be inserted gently to collect discharge or cells. Urine sample requires midstream collection in a sterile container.
Report Delivery
No special precautions. You may resume normal activities immediately.
Timeline: Reports are available on the 4th working day. Email reports within 48 hours, phone within 36 hours.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to qualitatively detect the presence of Treponema pallidum RNA in clinical specimens, confirming active syphilis infection. It is particularly useful in early primary syphilis, congenital syphilis, neurosyphilis, and cases where serological tests are inconclusive. The test also helps in evaluating treatment efficacy by detecting the clearance of the organism.
How to Prepare
- Blood: Collect in EDTA vacutainer, mix gently
- Swab: Use sterile flocked swab, rotate at collection site, place in transport medium
- Urine: Collect first-void urine (20-30 mL) in sterile container
- Ship immediately at 2-8°C to the laboratory
Doctor's Notes
Reviewed by Dr Kothari Ramesh Shantilal — MBBS, MD (Microbiology) · Reg. No. 27670
"Early detection of Treponema pallidum RNA is critical for initiating timely therapy and preventing late complications. This molecular test offers high sensitivity even in primary syphilis when serology may be negative."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received after prolonged delay (>72 hours) without proper storage
- Hemolyzed or clotted blood sample
- Swab without transport medium or dried out
- Urine sample with preservatives or not collected in sterile container
- Insufficient sample volume
Understanding Your Results
Detected
Active syphilis infection. Clinical correlation and treatment as per guidelines are recommended. Partner notification and follow-up testing advised.
Not detected
No Treponema pallidum RNA detected. However, if clinical suspicion is high, consider repeat testing or alternative diagnostic methods.
Consult your physician if you have symptoms suggestive of syphilis, a positive test result, or if you have been exposed to syphilis. Early treatment is crucial to prevent complications.
Limitations
- ⚠Qualitative test does not provide bacterial load quantification
- ⚠May not differentiate between active and past infection if RNA persists after treatment
- ⚠Negative result does not rule out infection if sample is inadequate or collected after antibiotic use
- ⚠Requires careful handling and rapid processing to maintain RNA integrity
Risks & Considerations
- ●Minimal risk of bleeding or hematoma at blood draw site
- ●Slight discomfort during swab collection
- ●No significant risks associated with the test
Interfering Factors
- ●Improper sample collection or storage may degrade RNA, leading to false negatives
- ●Presence of PCR inhibitors in the sample (e.g., hemoglobin, heparin)
- ●Contamination during collection or processing
- ●Recent antibiotic therapy may reduce bacterial load below detection limit
Compare With Similar Tests
| Test | Treponema Palladium (Syphilis) (RNA Detection) Qualitative Test | RPR (Rapid Plasma Reagin) | TPHA (Treponema pallidum Hemagglutination) | FTA-ABS (Fluorescent Treponemal Antibody Absorption) | Syphilis PCR (DNA) |
|---|---|---|---|---|---|
| Comparison | Treponema Palladium (Syphilis) (RNA Detection) Qualitative Test |
Frequently Asked Questions
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Is home sample collection available?
What does a 'Detected' result mean?
Can this test detect syphilis in the early primary stage?
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