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TRPM7 Gene Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility to NGS Genetic Test

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TRPM7 Gene Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility to NGS Genetic Test

Short Name: TRPM7 ALS-Parkinsonism/Dementia Complex NGS Test

Also known as: TRPM7 Gene Sequencing, TRPM7 Susceptibility Genetic Test, ALS-Parkinsonism/Dementia Complex NGS Test, TRPM7 Neurodegenerative Susceptibility Test

TRPM7 Gene Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks after the sample is received by the laboratory.. Free home collection in 300+ cities across India.

Neurology🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify clinically significant variants in the TRPM7 gene that may increase susceptibility to ALS-parkinsonism/dementia complex. NGS technology enables targeted analysis of the TRPM7 coding regions and splice sites, helping clinicians assess genetic risk and guide further evaluation of family members.

Test Code
3893
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks after the sample is received by the laboratory.
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No fasting is required. Please carry your clinical records, family history details and any referral notes provided by your doctor.

Method: Peripheral venipuncture or FTA card blood spot

Step 2

Laboratory Analysis

A trained phlebotomist will collect venous blood from the arm. For FTA card collection, a few drops of blood will be placed on the FTA card and allowed to dry.

Step 3

Report Delivery

No restrictions. You can resume normal activities immediately after sample collection.

Timeline: 3 to 4 weeks after the sample is received by the laboratory.

Patient Instructions

1
Before the Test:Before undergoing the test, a clinician or genetic counsellor will take a detailed personal and family history. The patient's clinical records and pedigree are essential for accurate interpretation of genetic findings.
2
During the Test:A simple blood sample is drawn from the arm. If extracted DNA is being submitted, it will be checked for quantity and quality before NGS processing.
3
After the Test:You will receive the report in 3 to 4 weeks. A genetic counsellor or doctor will explain the result, its implications and the next steps.

About This Test

Who Should Get This Test

The purpose of this test is to identify clinically significant variants in the TRPM7 gene that may increase susceptibility to ALS-parkinsonism/dementia complex. NGS technology enables targeted analysis of the TRPM7 coding regions and splice sites, helping clinicians assess genetic risk and guide further evaluation of family members.

How to Prepare

  • No fasting required.
  • A genetic counselling session is recommended before testing to draw a pedigree chart.
  • Provide family history of neurological disorders.
  • Use EDTA vacutainer for blood collection.
  • For FTA card, ensure the marked spots are fully saturated and dried completely.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"A positive or uncertain result should be interpreted in the context of clinical symptoms, family history and neurological examination. Genetic counselling is critical before and after testing."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for NGS
ContainerEDTA vacutainer / FTA card / DNA vial
Collection MethodPeripheral venipuncture or FTA card blood spot

Sample Stability

EDTA whole blood: 7 days at 2-8°C
Extracted DNA: 7 days at 2-8°C; long term at -20°C
FTA card: stable at room temperature for several months
Sample Rejection Criteria:
  • Hemolyzed or coagulated samples
  • Improperly labelled samples
  • Sample received after transport delay
  • FTA card not fully dried

Understanding Your Results

NGS results are correlated with the clinical presentation. Variants identified in the TRPM7 gene are classified according to ACMG/AMP guidelines and include recommendations where appropriate.
📊

Pathogenic / Likely Pathogenic variant

Indicates increased susceptibility and supports clinical correlation; genetic counselling recommended.

📊

Variant of Uncertain Significance (VUS)

Cannot be classified as pathogenic or benign; family studies may help clarify the risk.

📊

Benign / Likely Benign variant

Not considered a clinically significant risk factor for the condition.

📊

No pathogenic variants detected

Does not exclude the condition; other genetic and non-genetic causes may be considered.

⚠️ When to Consult a Doctor:

If you receive a pathogenic/likely pathogenic result or a VUS, please consult your referring neurologist or a clinical geneticist for personalised risk assessment.

Limitations

  • ⚠NGS may not detect all types of mutations such as large rearrangements or repeat expansions
  • ⚠TRPM7 gene variants may not be present in all individuals with ALS-parkinsonism/dementia complex
  • ⚠A susceptibility variant is not diagnostic of disease
  • ⚠Variant of uncertain significance (VUS) may require additional family studies
  • ⚠This test does not exclude other genetic or environmental causes

Risks & Considerations

  • ●Minor pain or bruising at the blood collection site
  • ●No genetic test can predict disease onset with certainty

Interfering Factors

  • ●Genomic DNA degradation
  • ●Sample contamination with maternal DNA
  • ●Incorrect sample labelling
  • ●Incomplete clinical or family history limiting variant interpretation

Compare With Similar Tests

TestTRPM7 Gene Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility to NGS Genetic Test
ComparisonTRPM7 Gene Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility to NGS Genetic Test

Frequently Asked Questions

What is the TRPM7 gene ALS-Parkinsonism/Dementia Complex NGS genetic test?
It is a next-generation sequencing test that looks for variants in the TRPM7 gene which may increase susceptibility to ALS-parkinsonism/dementia complex.
What sample is used for this test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required before this genetic test?
No, fasting is not required. However, you should carry your clinical and family history details.
How much does the test cost?
The price is Rs 20000.0 at DNA Labs India, with free home sample collection for online bookings.
How long does the report take?
Reports are generally available in 3 to 4 weeks after the sample is received.
Who should consider this genetic test?
People with clinical features of ALS, parkinsonism, dementia, or a family history of these disorders may consider the test after medical consultation.
Does this test diagnose ALS-parkinsonism/dementia complex?
No, this test identifies susceptibility variants, not a confirmed diagnosis. A neurologist or clinical geneticist must interpret the test along with other findings.
What does a pathogenic result mean?
It means a genetic variant linked to increased susceptibility was found; it should be interpreted with clinical and family information.
What is a variant of uncertain significance (VUS)?
A VUS is a genetic change whose effect on disease risk is unclear. Additional family or functional studies may be needed.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across major Indian cities for online bookings.
Should I have genetic counselling before testing?
Yes, a genetic counselling session is recommended to draw a pedigree chart and understand the benefits, risks, and limitations of testing.
Will insurance cover this test?
Coverage varies; genetic tests are often not covered by standard schemes. You should check with your insurance provider or scheme.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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