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TUSC3 Gene Mental retardation, autosomal recessive type 7 NGS Genetic Test

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TUSC3 Gene Mental retardation, autosomal recessive type 7 NGS Genetic Test

Short Name: TUSC3 Gene MRT7 NGS Genetic Test

Also known as: MRT7, Mental Retardation Autosomal Recessive Type 7

TUSC3 Gene Mental retardation, autosomal recessive type 7 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To confirm diagnosis of TUSC3 gene mental retardation, identify specific pathogenic variants in the TUSC3 gene, and provide actionable insights for clinical management and genetic counseling.

Test Code
1693
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide complete clinical history and family pedigree chart as advised during genetic counseling. No specific preparation or fasting is required.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Sample is collected via venipuncture (blood draw) or by applying one drop of blood on an FTA card. Collection is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Report any unusual symptoms like persistent pain or swelling.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consult with a genetic counselor or healthcare provider to discuss indications, benefits, and limitations. Provide clinical history and family details.
2
During the Test:Sample collection via blood draw or FTA card, followed by NGS analysis in the laboratory.
3
After the Test:Receive report within 3-4 weeks. Follow up with genetic counseling to understand results and next steps.

About This Test

Who Should Get This Test

To confirm diagnosis of TUSC3 gene mental retardation, identify specific pathogenic variants in the TUSC3 gene, and provide actionable insights for clinical management and genetic counseling.

How to Prepare

  • No fasting required
  • Ensure proper identification of the patient
  • Label samples correctly
  • Store blood samples at room temperature if not processed immediately

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing with NGS can confirm diagnosis and guide management for families affected by MRT7, aiding in early intervention and counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml of blood
ContainerEDTA tube for blood; FTA card for drop blood
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood samples stable at room temperature (15-30°C) for up to 48 hours
Extracted DNA stable at -20°C for long-term storage
FTA card samples stable at room temperature for extended periods
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Test results indicate the presence or absence of pathogenic variants in the TUSC3 gene associated with autosomal recessive mental retardation type 7.
📊

Pathogenic variant detected

Consistent with diagnosis of TUSC3 gene mental retardation. Genetic counseling recommended for family planning and management.

📊

No pathogenic variant detected

Unlikely to have TUSC3-related mental retardation. Clinical correlation and further testing may be considered if symptoms persist.

📊

Variant of uncertain significance (VUS)

Clinical significance not clear. Follow-up with genetic counselor and possible family studies recommended.

⚠️ When to Consult a Doctor:

If symptoms of mental retardation or developmental delays are present, after receiving genetic test results for interpretation, or for genetic counseling regarding family history.

Limitations

  • ⚠May not detect all genetic variants, such as large deletions or duplications
  • ⚠Results require interpretation by a genetic counselor or healthcare professional
  • ⚠Not a replacement for comprehensive clinical evaluation

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results; counseling provided

Interfering Factors

  • ●Sample degradation or improper storage
  • ●Contamination during sample collection or processing
  • ●Insufficient DNA quality or quantity

Compare With Similar Tests

TestTUSC3 Gene Mental retardation, autosomal recessive type 7 NGS Genetic TestKaryotypingWhole Exome SequencingFMR1 Gene TestChromosomal Microarray Analysis
ComparisonTUSC3 Gene Mental retardation, autosomal recessive type 7 NGS Genetic Test

Frequently Asked Questions

What is TUSC3 gene mental retardation?
TUSC3 gene mental retardation, or MRT7, is a rare autosomal recessive condition caused by mutations in the TUSC3 gene, leading to intellectual disability and developmental delays.
What are the symptoms of TUSC3 gene mental retardation?
Common symptoms include delayed speech, poor muscle tone, intellectual disability, seizures, abnormal facial features, and difficulty walking.
How is the NGS genetic test performed?
The test uses next-generation sequencing to analyze the TUSC3 gene from a blood sample or DNA extract, identifying specific mutations.
What is the cost of the TUSC3 gene NGS test in India?
The cost at DNA Labs India is INR 20,000, which includes home collection, analysis, and genetic counseling.
Is home sample collection available?
Yes, free home sample collection is available across India for this test, with online booking.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
Who should consider getting this genetic test?
Individuals with symptoms of mental retardation, family history of MRT7, or those recommended by a healthcare provider for genetic evaluation.
What does a positive test result mean?
A positive result indicates the presence of pathogenic variants in the TUSC3 gene, confirming diagnosis and guiding management and counseling.
Can the test be performed on children?
Yes, the test can be performed on individuals of all ages, including children, with appropriate parental consent.
Is genetic counseling included with the test?
Yes, a genetic counseling session is included to help interpret results and provide guidance.
What is NGS technology?
Next-generation sequencing (NGS) is a high-throughput method that analyzes multiple genes simultaneously, offering detailed insights into genetic mutations.
How accurate is the TUSC3 gene NGS test?
The test is highly accurate for detecting mutations in the TUSC3 gene, but accuracy depends on sample quality and laboratory standards; results should be interpreted by a professional.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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