UNC13B Gene Autism, UNC13B Related NGS Genetic Test
Short Name: UNC13B NGS Genetic Test
Also known as: UNC13B Autism NGS Test, UNC13B Gene Sequencing, UNC13B Related NGS Panel
UNC13B Gene Autism, UNC13B Related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The clinical report is usually issued within 3 to 4 weeks from sample receipt. Raw data files (FASTQ, VCF) are shared alongside the report.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect pathogenic or likely pathogenic variants in the UNC13B gene, known to be associated with autism spectrum disorder. It provides molecular confirmation to support clinical diagnosis, enables precise genetic counseling, and helps guide therapeutic and educational interventions for affected individuals.
- Test Code
- 3926
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- The clinical report is usually issued within 3 to 4 weeks from sample receipt. Raw data files (FASTQ, VCF) are shared alongside the report.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No special preparation is required. The patient should have a completed clinical history form and genetic counseling session before testing. For children, parents or guardians may be present.
Method: Venipuncture or dried blood spot on FTA card
Laboratory Analysis
Blood is drawn by a trained phlebotomist using sterile technique. For FTA card sampling, a few drops of blood are placed on the card and dried. Extracted DNA samples are transferred to the laboratory in appropriate conditions.
Report Delivery
The sample is logged and transported to the laboratory at optimal temperature. Patients can track their sample status and will be notified when the report is ready. No post-tests restrictions apply.
Timeline: The clinical report is usually issued within 3 to 4 weeks from sample receipt. Raw data files (FASTQ, VCF) are shared alongside the report.
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect pathogenic or likely pathogenic variants in the UNC13B gene, known to be associated with autism spectrum disorder. It provides molecular confirmation to support clinical diagnosis, enables precise genetic counseling, and helps guide therapeutic and educational interventions for affected individuals.
How to Prepare
- Use EDTA tube for whole blood collection; do not use heparin.
- For FTA card, apply one readable drop of blood and allow to air dry for 1 hour.
- For extracted DNA, ensure a minimum of 2-5µg in a sterile DNA-free tube.
- Label the sample with patient name, date of birth, and collection date.
- Maintain sample at room temperature if dispatched within 24 hours; otherwise store at 2-8°C.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"A confirmed genetic diagnosis in autism can guide early intervention, medication selection, and family planning decisions. This targeted NGS test for UNC13B is a valuable component of a comprehensive autism evaluation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolysed blood sample without clear labeling
- Insufficient quantity of blood or DNA
- FTA card with contaminated spots or contaminated bacterial growth
- Sample received in a plain tube without anticoagulant
- Sample that has been kept at room temperature for more than 4 days
Understanding Your Results
Pathogenic/Likely Pathogenic variant detected
Consistent with a genetic cause for autism phenotype in the proband. Genetic counseling and segregation analysis in family members are recommended.
Recommendation: Clinical correlation with neurodevelopmental assessment; discuss recurrence risk and targeted interventions.
Variants of Uncertain Significance (VUS) detected
A gene variant was found but its clinical significance is unknown. Further family studies or functional tests may clarify.
Recommendation: Consider parental testing and follow-up with clinical geneticist.
No pathogenic variant detected
No mutation in the UNC13B gene was found. Autism may be due to other genes or environmental factors.
Recommendation: Consider broader autism NGS panel or chromosomal microarray analysis.
If you observe autism-like symptoms in your child, such as social communication deficits, restricted behaviors, or speech delay, or if there is a family history of UNC13B-related disorders, consult a clinical geneticist or pediatric neurologist for comprehensive evaluation and genetic testing.
Limitations
- ⚠This test analyzes only the UNC13B gene; it does not evaluate other genes associated with autism.
- ⚠NGS may not reliably detect large structural rearrangements, repeat expansions, or deep intronic variants outside the covered region.
- ⚠A negative result does not exclude a genetic or non-genetic cause of autism.
- ⚠Variants of uncertain significance (VUS) may be reported; further family studies may be needed for classification.
Risks & Considerations
- ●No significant physical risks associated with blood collection except minor pain, bruising, or rare infection.
- ●Psychological impact of receiving a genetic result — genetic counseling is provided.
- ●Possible findings of uncertain significance or secondary findings requiring additional testing.
Interfering Factors
- ●Maternal cell contamination in fetal or cord blood samples
- ●Extreme hemolysis or clotted blood sample
- ●DNA degradation due to improper storage or transport
- ●Presence of donor-derived DNA after bone marrow transplant
- ●Incomplete clinical history or incorrect pedigree information
Compare With Similar Tests
| Test | UNC13B Gene Autism, UNC13B Related NGS Genetic Test | UNC13B NGS Genetic Test | Autism Spectrum Disorder Full Panel | Chromosomal Microarray (CMA) | Fragile X Syndrome Test |
|---|---|---|---|---|---|
| Comparison | UNC13B Gene Autism, UNC13B Related NGS Genetic Test |
Frequently Asked Questions
What is the UNC13B gene?
How is UNC13B related to autism?
What does the UNC13B NGS genetic test detect?
Who should consider this test?
What sample types are accepted?
Do I need to fast before the test?
How long does it take to receive results?
What is the cost of the UNC13B NGS genetic test?
Is home sample collection available?
What if my result is positive for a mutation?
What if my result is negative?
Will insurance cover the test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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