VCP Gene Amyotrophic Lateral Sclerosis Type 14 NGS Genetic Test
Short Name: VCP ALS Type 14 NGS
Also known as: VCP Gene NGS Test, ALS Type 14 Genetic Test, VCP-Related ALS NGS Panel
VCP Gene Amyotrophic Lateral Sclerosis Type 14 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Variant analysis by ACMG guidelines on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are issued in 3 to 4 weeks after receipt of the sample and completion of all quality checks.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to identify pathogenic variants in the VCP gene associated with ALS type 14. Molecular confirmation helps differentiate ALS type 14 from other forms of ALS and provides a definitive diagnosis for early disease management, genetic counseling, and risk assessment for at-risk family members.
- Test Code
- 3880
- ICD Code
- G12.21
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are issued in 3 to 4 weeks after receipt of the sample and completion of all quality checks.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Variant analysis by ACMG guidelines
Sample Collection
Please provide complete clinical history and family pedigree. A genetic counseling session is recommended before blood collection. No fasting is required.
Method: Peripheral venipuncture or FTA card blood spot
Laboratory Analysis
A trained phlebotomist will draw blood from a vein in your arm. For FTA card, a drop of blood from a fingerstick will be placed on the card.
Report Delivery
You may resume normal activities immediately. The puncture site may be sore for a short time; apply pressure if bleeding persists.
Timeline: Reports are issued in 3 to 4 weeks after receipt of the sample and completion of all quality checks.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to identify pathogenic variants in the VCP gene associated with ALS type 14. Molecular confirmation helps differentiate ALS type 14 from other forms of ALS and provides a definitive diagnosis for early disease management, genetic counseling, and risk assessment for at-risk family members.
How to Prepare
- No fasting is required.
- Bring a valid physician prescription and government ID.
- Wear short-sleeved clothing for easy blood draw.
- Inform the collection team if you are on anticoagulant therapy.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic confirmation in ALS enables more accurate prognosis, clinical trial access, and family cascade testing by a multidisciplinary team."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood
- Incorrectly labeled sample
- Insufficient sample volume
- Suspected contamination
Understanding Your Results
Pathogenic/likely pathogenic variant detected. Consistent with VCP-associated ALS type 14.
Status: Positive
No clinically significant variant identified. ALS may be due to another genetic or non-genetic cause.
Status: Negative
Variant of uncertain significance. Additional familial testing and functional studies may be needed.
Status: VUS
If you or a family member have symptoms such as muscle weakness, slurred speech, swallowing problems, or breathing difficulty, consult a neurologist at the earliest. Genetic testing should be done under medical supervision.
Limitations
- ⚠This test analyzes only the VCP gene; other ALS-associated genes are not assessed.
- ⚠Regulatory, deep intronic or large structural variants may not be detected.
- ⚠Variant of uncertain significance (VUS) may require additional familial testing or functional studies.
- ⚠This test cannot assess the progression rate or severity of ALS.
Risks & Considerations
- ●Slight pain or bruising at the venipuncture site
- ●Very low risk of infection
- ●Psychological impact of a genetic diagnosis
Interfering Factors
- ●Low DNA yield or poor sample quality
- ●Contamination or maternal cell admixture
- ●Incomplete coverage of GC-rich regions
- ●Use of anticoagulants other than EDTA
Compare With Similar Tests
| Test | VCP Gene Amyotrophic Lateral Sclerosis Type 14 NGS Genetic Test | SOD1 Gene ALS Genetic Test | C9orf72 Gene ALS Genetic Test |
|---|---|---|---|
| Comparison | VCP Gene Amyotrophic Lateral Sclerosis Type 14 NGS Genetic Test |
Frequently Asked Questions
What is ALS type 14?
What is the VCP gene?
How is ALS type 14 diagnosed?
What is NGS genetic testing?
How long does the test take?
What is the cost of the test?
Is home sample collection available?
What kind of sample is required?
Does this test require fasting?
What does a positive result mean?
Should I have genetic counseling before testing?
Can this test be used for at-risk relatives?
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