VPS35 Gene PARK17 Parkinson NGS Genetic Test
Short Name: VPS35 PARK17 NGS Test
Also known as: VPS35 Genetic Test, PARK17 Gene Test, VPS35 Parkinson Disease NGS Test, Vacuolar Protein Sorting 35 Gene Test, Hereditary Parkinson Genetic Test
VPS35 Gene PARK17 Parkinson NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger Confirmation Sequencing, Bioinformatics Pipeline Analysis, Variant Annotation and Classification on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Results will be delivered via the patient's preferred method: online portal, email, or WhatsApp. In some cases, additional confirmatory testing (such as Sanger sequencing for variant confirmation) may extend the turnaround time, and the patient will be notified accordingly.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the VPS35 Gene PARK17 Parkinson NGS Genetic Test is to identify pathogenic or likely pathogenic mutations in the VPS35 gene that are associated with hereditary Parkinson's Disease. This test aids clinicians in confirming a genetic etiology for parkinsonian symptoms, differentiating hereditary Parkinson's Disease from idiopathic or other genetic forms, identifying at-risk family members through predictive or carrier testing, informing prognosis and potential treatment pathways, and facilitating informed genetic counseling for patients and their families.
- Test Code
- 1787
- CPT Code
- 81479
- ICD Code
- G20
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One Drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Results will be delivered via the patient's preferred method: online portal, email, or WhatsApp. In some cases, additional confirmatory testing (such as Sanger sequencing for variant confirmation) may extend the turnaround time, and the patient will be notified accordingly.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Sanger Confirmation Sequencing, Bioinformatics Pipeline Analysis, Variant Annotation and Classification
Sample Collection
No special preparation such as fasting is required before sample collection. Patients should provide complete clinical history and undergo a pre-test genetic counseling session to discuss the implications of testing, expected outcomes, and family history. A pedigree chart of affected family members should be prepared during the counseling session.
Method: Venipuncture or Finger Prick (FTA Card)
Laboratory Analysis
A standard venipuncture blood draw (3-5 mL in an EDTA tube) or a finger prick to collect one drop of blood onto an FTA card will be performed by a trained phlebotomist. The procedure is minimally invasive and typically takes less than 5 minutes. For FTA card collection, the finger is pricked and a single drop of blood is applied to the designated area of the card and allowed to dry completely.
Report Delivery
After sample collection, gentle pressure should be applied to the venipuncture site with a cotton ball or gauze to prevent bruising. No specific post-collection restrictions are necessary. The sample will be transported under controlled conditions to DNA Labs India's NABL-accredited laboratory for processing. Results will be available in approximately 3 to 4 weeks and delivered via online portal, email, or WhatsApp.
Timeline: Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Results will be delivered via the patient's preferred method: online portal, email, or WhatsApp. In some cases, additional confirmatory testing (such as Sanger sequencing for variant confirmation) may extend the turnaround time, and the patient will be notified accordingly.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the VPS35 Gene PARK17 Parkinson NGS Genetic Test is to identify pathogenic or likely pathogenic mutations in the VPS35 gene that are associated with hereditary Parkinson's Disease. This test aids clinicians in confirming a genetic etiology for parkinsonian symptoms, differentiating hereditary Parkinson's Disease from idiopathic or other genetic forms, identifying at-risk family members through predictive or carrier testing, informing prognosis and potential treatment pathways, and facilitating informed genetic counseling for patients and their families.
How to Prepare
- No fasting is required prior to sample collection
- Carry a valid government-issued photo ID and the test requisition form
- Inform the phlebotomist about any recent blood transfusions or bone marrow transplants
- For FTA card collection, ensure hands are clean and dry before the finger prick
- Wear a short-sleeved or loose-fitting shirt for easy venipuncture access
- Stay hydrated before sample collection to ensure easier blood draw
- Bring all relevant medical records, prescriptions, and family history information
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"The VPS35 gene mutation is one of the rarer but well-characterized causes of autosomal dominant Parkinson's Disease. I recommend this test for patients presenting with early-onset parkinsonism, especially when there is a clear family history suggesting dominant inheritance. A positive result helps confirm a genetic etiology and may inform decisions regarding long-term management, family screening, and eligibility for emerging gene-targeted therapies. It is essential that results are interpreted alongside clinical findings and in the context of a comprehensive neurological evaluation. Genetic counseling should accompany both pre-test and post-test phases to help patients and families understand implications and next steps."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed, clotted, or insufficient sample volume
- Improperly labeled or unlabeled samples
- Samples collected in incorrect container type (non-EDTA tubes)
- Samples older than 72 hours (whole blood in EDTA) without prior arrangement
- Contaminated FTA card samples
- Samples without accompanying test requisition form or clinical history
Understanding Your Results
Pathogenic Variant Detected
A known disease-causing mutation in the VPS35 gene has been identified. This finding is consistent with a genetic diagnosis of PARK17-associated Parkinson's Disease. Genetic counseling and further clinical evaluation are strongly recommended. Family members may benefit from predictive testing.
Likely Pathogenic Variant Detected
A variant that is likely to cause disease has been identified based on available evidence. Clinical correlation and genetic counseling are recommended. Confirmation with family segregation studies may be advised.
Variant of Uncertain Significance (VUS)
A genetic change has been detected, but there is currently insufficient evidence to classify it as pathogenic or benign. This result should not be used alone for clinical decision-making. Periodic reclassification as new evidence becomes available is recommended.
Likely Benign / Benign Variant Detected
A genetic variant was identified but is classified as unlikely to be associated with disease. This finding does not confirm a genetic basis for Parkinson's Disease.
No Pathogenic Variant Detected
No disease-causing mutations in the VPS35 gene were identified. This result does not completely rule out a genetic cause of Parkinson's Disease, as mutations in other genes may be responsible. Clinical follow-up and consideration of expanded gene panel testing may be appropriate.
You should consult a neurologist or medical geneticist if you experience any symptoms of Parkinson's Disease such as resting tremor, muscle rigidity, slowness of movement (bradykinesia), balance or coordination difficulties, or if you have a family history of Parkinson's Disease. If your genetic test result returns positive for a pathogenic variant, or if a VUS is identified, consultation with a genetic counselor is strongly recommended to understand the implications for yourself and your family members. Early consultation allows for timely management, family screening, and access to emerging gene-specific therapies.
Limitations
- ⚠This test only analyzes the VPS35 (PARK17) gene and does not detect mutations in other genes associated with Parkinson's Disease (e.g., LRRK2, PARK2, SNCA, PINK1, GBA)
- ⚠Large genomic rearrangements (copy number variations) may not be fully detected by standard NGS sequencing
- ⚠A negative result does not eliminate the possibility of Parkinson's Disease, as the condition can have non-genetic or multifactorial causes
- ⚠Variants of uncertain significance (VUS) may be identified, and their clinical relevance cannot be definitively determined at the time of reporting
- ⚠Deep intronic or regulatory region variants outside the sequenced regions may not be detected
- ⚠Results should always be interpreted in the context of clinical findings and family history by a qualified healthcare provider
Risks & Considerations
- ●Minimal physical risk: minor bruising or discomfort at the venipuncture or finger prick site
- ●Psychological impact: test results may cause anxiety, distress, or emotional reactions, particularly for predictive or presymptomatic testing
- ●Potential implications for insurance: genetic test results may have implications for life or health insurance in some jurisdictions; patients should be informed about genetic non-discrimination protections where applicable
- ●Incidental findings: in rare cases, variants of uncertain significance (VUS) or unexpected findings may be identified, requiring additional counseling
- ●Family implications: positive results may have emotional and psychological effects on family members who may also be at risk
Interfering Factors
- ●Recent blood transfusion (within the past 4 weeks) may affect DNA analysis
- ●Bone marrow or stem cell transplant can result in donor DNA contamination
- ●Degraded or insufficient DNA quality may lead to test failure or inconclusive results
- ●Hemolyzed blood samples may compromise DNA extraction
- ●Concurrent use of certain medications does not directly interfere but should be documented
Compare With Similar Tests
| Test | VPS35 Gene PARK17 Parkinson NGS Genetic Test | VPS35 Gene PARK17 Parkinson NGS Genetic Test | Comprehensive Parkinson's Disease Gene Panel | LRRK2 Gene Single Gene Test |
|---|---|---|---|---|
| Comparison | VPS35 Gene PARK17 Parkinson NGS Genetic Test |
Frequently Asked Questions
What is the VPS35 Gene PARK17 Parkinson NGS Genetic Test?
Who should consider getting the VPS35 PARK17 genetic test?
What sample type is required for this genetic test?
How long does it take to receive the results?
What does a positive (pathogenic variant detected) result mean?
What does a negative result mean?
Is the sample collection painful or risky?
Can this test definitively diagnose Parkinson's Disease?
Is genetic counseling recommended before and after the test?
What is the cost of the VPS35 Gene PARK17 Parkinson NGS Genetic Test?
Is home sample collection available for this test?
Will I receive raw data files along with my clinical report?
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