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VPS37A Gene SPG53 NGS Genetic Test

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VPS37A Gene SPG53 NGS Genetic Test

VPS37A Gene SPG53 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS) Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To confirm the presence of VPS37A gene mutations for diagnosis of Spastic Paraplegia 53 (SPG53).

Test Code
1809
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling.

Step 2

Laboratory Analysis

Blood sample or extracted DNA collected.

Step 3

Report Delivery

Sample sent for analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment.
2
During the Test:Sample collection via blood draw or DNA extraction.
3
After the Test:Wait for report, which takes 3-4 weeks.

About This Test

Who Should Get This Test

To confirm the presence of VPS37A gene mutations for diagnosis of Spastic Paraplegia 53 (SPG53).

How to Prepare

  • No fasting required. Ensure sample is properly collected and labeled.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for VPS37A mutations confirms SPG53 diagnosis, aiding in early intervention and genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Understanding Your Results

Results indicate the presence or absence of mutations in the VPS37A gene.
📊

Positive for pathogenic mutation

Confirmatory diagnosis of SPG53. Genetic counseling recommended for management and family planning.

📊

Negative for pathogenic mutation

SPG53 unlikely, but clinical correlation advised due to variable symptoms.

⚠️ When to Consult a Doctor:

If symptoms suggestive of SPG53 are present, or for genetic counseling after test results.

Limitations

  • ⚠May not detect all types of mutations or variants of uncertain significance

Risks & Considerations

  • ●Minimal risk of bruising or infection from blood draw

Frequently Asked Questions

What is SPG53?
SPG53 is a rare genetic disorder causing spastic paraplegia due to mutations in the VPS37A gene, leading to muscle weakness and spasticity.
What are the symptoms of SPG53?
Symptoms include muscle weakness, spasticity in limbs, developmental delay, cognitive impairment, seizures, abnormal eye movements, and joint contractures.
How is SPG53 diagnosed?
Diagnosis involves clinical evaluation and genetic testing like the VPS37A Gene NGS Test to confirm mutations.
What is the cost of the VPS37A Gene NGS Test in India?
The cost is approximately INR 20,000, with free home sample collection available for online bookings.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across India for online bookings.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks.
What sample is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Who should consider getting tested for SPG53?
Individuals with symptoms of hereditary spastic paraplegia or a family history of similar conditions should consider testing.
Can this test detect all mutations in the VPS37A gene?
While NGS detects most mutations, it may not identify all types or variants of uncertain significance.
Is genetic counseling recommended before testing?
Yes, genetic counseling is recommended before and after testing to understand implications and results.
What should I do if the test result is positive?
A positive result confirms SPG53 diagnosis. Consult a healthcare professional for management and genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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