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WASHC5 Gene SPG8 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

WASHC5 Gene SPG8 NGS Genetic Test

Short Name: SPG8 NGS Genetic Test

Also known as: Hereditary Spastic Paraplegia Type 8 Genetic Test, WASHC5 Gene Test

WASHC5 Gene SPG8 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the WASHC5 Gene SPG8 NGS Genetic Test is to diagnose Hereditary Spastic Paraplegia Type 8 by detecting mutations in the WASHC5 gene, aiding in clinical evaluation, genetic counseling, and personalized management of neurological symptoms.

Test Code
1828
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history review and genetic counseling session to draw a family pedigree chart.

Method: Blood draw or saliva collection

Step 2

Laboratory Analysis

Standard blood draw or saliva sample collection using aseptic techniques.

Step 3

Report Delivery

Sample processing in the laboratory with report delivery in 3-4 weeks.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review to ensure test appropriateness.
2
During the Test:Sample collection via blood draw or saliva, processed using NGS technology.
3
After the Test:Report generation and delivery with optional genetic counseling for result interpretation.

About This Test

Who Should Get This Test

The purpose of the WASHC5 Gene SPG8 NGS Genetic Test is to diagnose Hereditary Spastic Paraplegia Type 8 by detecting mutations in the WASHC5 gene, aiding in clinical evaluation, genetic counseling, and personalized management of neurological symptoms.

How to Prepare

  • Provide informed consent and clinical history
  • Ensure proper sample labeling and handling
  • For blood samples, avoid hemolysis; for FTA cards, follow kit instructions

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or saliva collection

Sample Stability

Blood samples: Stable at ambient temperature for up to 48 hours
Extracted DNA: Store at -20°C for long-term
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results of the WASHC5 Gene SPG8 NGS Genetic Test are interpreted based on the detection of mutations in the WASHC5 gene. Positive results indicate a genetic predisposition for SPG8, while negative results suggest no pathogenic variants detected.
📊

Positive

Pathogenic mutation detected in WASHC5 gene, consistent with SPG8. Clinical correlation and genetic counseling recommended.

📊

Negative

No pathogenic mutations detected in WASHC5 gene. Symptoms may be due to other causes; further evaluation advised.

📊

Variant of Uncertain Significance (VUS)

A genetic variant was identified but its clinical significance is unknown. Repeat testing or family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience progressive muscle stiffness, walking difficulties, or have a family history of SPG8. Genetic counseling is recommended before and after testing.

Limitations

  • ⚠May not detect all genetic variants or deep intronic mutations
  • ⚠Results require clinical correlation and genetic counseling
  • ⚠Does not rule out other genetic or non-genetic causes of symptoms

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results; counseling available

Interfering Factors

  • ●Hemolyzed or degraded DNA samples
  • ●Contamination during sample collection

Frequently Asked Questions

What is the WASHC5 Gene SPG8 NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing (NGS) to analyze the WASHC5 gene for mutations associated with Hereditary Spastic Paraplegia Type 8 (SPG8), a rare neurological disorder.
What are the symptoms of SPG8?
Symptoms include progressive muscle stiffness and weakness in the legs, difficulty walking, spasticity, speech difficulties, and abnormal reflexes.
How is the test performed?
The test involves collecting a blood or saliva sample, which is analyzed in a laboratory using NGS technology to detect mutations in the WASHC5 gene.
What is the cost of the test?
The cost is INR 20,000 at DNA Labs India, which includes test, genetic counseling, and result interpretation.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across numerous cities in India.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks via online portal, email, or WhatsApp.
Do I need to fast before the test?
No, fasting is not required for this test.
What should I do before getting tested?
Provide clinical history and undergo genetic counseling to draw a family pedigree chart. Ask for raw data, FASTQ, and VCF files for transparency.
What do positive results mean?
Positive results indicate a mutation in the WASHC5 gene, suggesting a diagnosis of SPG8. Consult a doctor for further management.
Can this test detect other genetic conditions?
No, it specifically targets the WASHC5 gene for SPG8. For broader analysis, consider a neurological genetic panel.
Is genetic counseling provided?
Yes, genetic counseling is included as part of the test package to help interpret results and provide guidance.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, but psychological impact may occur; counseling is available to address concerns.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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