XBP1 Gene Major affective disorder 7 NGS Genetic Test
Short Name: XBP1 MAD7 NGS Test
Also known as: XBP1 Gene Sequencing Test, MAD7 Genetic Test, XBP1 Mutation Analysis, Major Affective Disorder 7 Gene Test, XBP1 Next-Generation Sequencing Test
XBP1 Gene Major affective disorder 7 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the XBP1 Gene Major Affective Disorder 7 NGS Genetic Test is to detect clinically significant genetic variants in the XBP1 gene that may confer an increased risk for developing Major Affective Disorder 7. By identifying pathogenic or likely pathogenic variants, this test supports risk assessment, early identification of at-risk individuals, and informed clinical management. It is intended to complement, not replace, a comprehensive psychiatric evaluation and should be interpreted alongside clinical findings and family history.
- Test Code
- 1680
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
A pre-test genetic counselling session is recommended to discuss the purpose, implications, and potential outcomes of the test. The patient or a family member should provide a detailed clinical history and a comprehensive family pedigree. No fasting is required before sample collection.
Method: Venipuncture
Laboratory Analysis
A standard venipuncture blood draw is performed to collect 3-5 mL of blood in an EDTA vacutainer. Alternatively, a single drop of blood on an FTA card may be used. The collection procedure typically takes 5 to 10 minutes.
Report Delivery
The collected sample is transported to the DNA Labs India genetics laboratory under controlled ambient conditions. DNA extraction, library preparation, and NGS sequencing are performed. Results are typically available within 3 to 4 weeks and shared via the online portal, email, or WhatsApp.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the XBP1 Gene Major Affective Disorder 7 NGS Genetic Test is to detect clinically significant genetic variants in the XBP1 gene that may confer an increased risk for developing Major Affective Disorder 7. By identifying pathogenic or likely pathogenic variants, this test supports risk assessment, early identification of at-risk individuals, and informed clinical management. It is intended to complement, not replace, a comprehensive psychiatric evaluation and should be interpreted alongside clinical findings and family history.
How to Prepare
- No fasting is required prior to sample collection
- Carry a valid government-issued photo identification document
- Bring all relevant previous medical records, psychiatric evaluations, and family history documentation
- Inform the phlebotomist of any recent blood transfusions within the past 120 days
- A genetic counselling session is strongly recommended before the test
- Ensure the sample is collected by a trained phlebotomist using sterile technique
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"As a psychiatrist, I regularly encounter patients with treatment-resistant mood disorders where a genetic predisposition is strongly suspected. The XBP1 Gene Major Affective Disorder 7 NGS Genetic Test provides valuable information about genetic risk factors that can inform personalized treatment strategies. For patients with a significant family history of mood disorders, or those who have not responded adequately to standard pharmacological interventions, understanding the XBP1 genetic profile can guide medication selection and therapeutic approaches. I recommend this test as part of a comprehensive psychiatric evaluation, always in conjunction with genetic counselling to ensure patients fully understand the implications of their results."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume (less than 2 mL of blood)
- Hemolyzed, clotted, or severely lipemic blood samples
- Improperly labeled or unlabeled samples
- Samples not stored or transported at recommended temperature conditions
- Samples collected in inappropriate anticoagulant tubes (non-EDTA)
- FTA card samples with visible contamination or damage
Understanding Your Results
Pathogenic variant detected
A known disease-causing variant in the XBP1 gene has been identified. This indicates an increased genetic susceptibility to Major Affective Disorder 7. Clinical correlation with symptoms and family history is essential. Genetic counselling and psychiatric evaluation are strongly recommended.
Likely pathogenic variant detected
A variant that is probably associated with disease risk has been found in the XBP1 gene. Further clinical evaluation, family segregation studies, and periodic reclassification of the variant are recommended.
Variant of uncertain significance (VUS)
A genetic variant was detected whose clinical significance cannot be determined with currently available evidence. This result should not be used for clinical decision-making. Family studies and longitudinal follow-up may help clarify the variant's role over time.
Likely benign variant detected
A variant was identified that is unlikely to be associated with an increased risk for MAD7. No specific clinical action is typically warranted based on this finding alone.
No pathogenic variant detected
No known pathogenic or likely pathogenic variants in the XBP1 gene were identified. This result does not completely rule out a genetic predisposition to MAD7, as other genes and environmental factors may contribute to disease risk.
Consult your psychiatrist or genetic counsellor if you have a family history of mood disorders, experience recurrent or treatment-resistant episodes of depression or mania, if your test results reveal a pathogenic or likely pathogenic variant in the XBP1 gene, or if you have questions about the implications of your genetic test results for treatment planning and family risk assessment.
Limitations
- ⚠This test specifically analyzes the XBP1 gene only and may not detect variants in other genes implicated in mood disorders
- ⚠The presence of a pathogenic variant does not guarantee that the individual will develop MAD7, as penetrance may be incomplete
- ⚠Variants of uncertain significance (VUS) may be identified, which require further research and family studies for classification
- ⚠This test is not a standalone diagnostic tool for Major Affective Disorder 7 and must be used alongside clinical evaluation
- ⚠Structural variants, large deletions, or duplications beyond the detection capability of NGS may not be identified
- ⚠Mitochondrial DNA variants and epigenetic modifications are not assessed by this test
Risks & Considerations
- ●Minimal risk associated with blood draw, including minor bruising, soreness, or rare infection at the venipuncture site
- ●Psychological and emotional impact of receiving genetic risk information; counselling support is recommended
- ●Genetic information may have potential implications for insurance, employment discrimination, and family planning decisions
- ●Risk of misinterpretation of results without appropriate genetic counselling and clinical context
Interfering Factors
- ●Hemolyzed blood samples may compromise DNA extraction quality and sequencing accuracy
- ●Heavily contaminated samples may produce unreliable or uninterpretable results
- ●Recent blood transfusion (within 120 days) may introduce donor DNA and affect variant calling
- ●Improper sample storage or transport conditions may degrade DNA integrity
- ●Use of certain anticoagulants other than EDTA may interfere with DNA extraction
Frequently Asked Questions
What is the XBP1 Gene Major Affective Disorder 7 NGS Genetic Test?
Who should consider getting the XBP1 Gene MAD7 Genetic Test?
What sample is required for this genetic test?
How long does it take to receive the test results?
What does a positive result mean?
Can this test diagnose Major Affective Disorder 7?
Is genetic counselling required before taking this test?
What is the cost of the XBP1 Gene MAD7 NGS Genetic Test?
Is the XBP1 Gene MAD7 Genetic Test covered by insurance?
Does DNA Labs India offer home sample collection for this test?
What is NGS technology and how is it used in this test?
What should I do after receiving my test results?
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