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ZC4H2 Gene Wieacker-Wolff syndrome NGS Genetic Test

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ZC4H2 Gene Wieacker-Wolff syndrome NGS Genetic Test

Short Name: ZC4H2 Gene Wieacker-Wolff Syndrome Test

Also known as: ZC4H2 gene mutation test, Wieacker-Wolff syndrome genetic test

ZC4H2 Gene Wieacker-Wolff syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose Wieacker-Wolff Syndrome by detecting mutations in the ZC4H2 gene and provide information for genetic counseling and family planning.

Test Code
4611
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling session.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collection via venipuncture.

Step 3

Report Delivery

Sample sent to laboratory for DNA extraction and analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment.
2
During the Test:Sample collection and DNA extraction for NGS analysis.
3
After the Test:Report generation and genetic counseling for result interpretation.

About This Test

Who Should Get This Test

To diagnose Wieacker-Wolff Syndrome by detecting mutations in the ZC4H2 gene and provide information for genetic counseling and family planning.

How to Prepare

  • Fasting not required
  • Bring valid ID and prescription
  • Inform about current medications

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of Wieacker-Wolff syndrome allows for timely intervention and informed family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA tube for blood
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the ZC4H2 gene.
Normal: No pathogenic variants detected
Abnormal: Pathogenic variant detected, consistent with Wieacker-Wolff Syndrome
Variant of uncertain significance: Further testing or counseling recommended
⚠️ When to Consult a Doctor:

If symptoms of Wieacker-Wolff syndrome are present or for genetic counseling after receiving test results.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires genetic counseling for interpretation

Risks & Considerations

  • ●Bruising at blood draw site
  • ●Infection risk
  • ●Fainting during venipuncture

Interfering Factors

  • ●Sample degradation
  • ●Contamination
  • ●Technical errors

Compare With Similar Tests

TestZC4H2 Gene Wieacker-Wolff syndrome NGS Genetic TestMECP2 Gene Test for Rett SyndromeSCN1A Gene Test for Dravet Syndrome
ComparisonZC4H2 Gene Wieacker-Wolff syndrome NGS Genetic TestDifferent gene and syndrome, but similar NGS methodology for neurological disorders.Focuses on epilepsy-related genes, while ZC4H2 test targets Wieacker-Wolff syndrome.

Frequently Asked Questions

What is Wieacker-Wolff Syndrome?
Wieacker-Wolff Syndrome is a rare X-linked genetic disorder affecting the nervous system, caused by mutations in the ZC4H2 gene, leading to intellectual disability, seizures, and muscle weakness.
What causes Wieacker-Wolff Syndrome?
It is caused by mutations in the ZC4H2 gene, which provides instructions for a protein essential for nerve cell development and function.
How is the ZC4H2 gene test performed?
The test uses Next Generation Sequencing (NGS) technology to analyze DNA from blood samples for mutations in the ZC4H2 gene.
What are the symptoms of Wieacker-Wolff Syndrome?
Symptoms include intellectual disability, seizures, muscle weakness, spasticity, delayed speech, and behavioral problems.
Who should get this genetic test?
Individuals with symptoms of Wieacker-Wolff syndrome or a family history of the condition should consider this test.
What is the cost of the test?
The cost is INR 20000, which includes sample collection, DNA extraction, testing, and reporting.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, free home sample collection is available across many cities in India for online bookings.
What do the test results mean?
Results indicate whether pathogenic mutations in the ZC4H2 gene are detected, aiding in diagnosis and genetic counseling.
Is genetic counseling necessary?
Yes, genetic counseling is recommended before and after testing to understand the implications and for family planning.
Are there any risks associated with the test?
Risks are minimal and related to blood draw, such as bruising or infection.
How accurate is the NGS genetic test?
The NGS test is highly accurate for detecting mutations in the ZC4H2 gene, with state-of-the-art technology ensuring reliability.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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