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ZDHHC15 Gene Mental retardation, X-linked type 91 NGS Genetic Test

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ZDHHC15 Gene Mental retardation, X-linked type 91 NGS Genetic Test

Short Name: ZDHHC15 MRX91 NGS Test

Also known as: MRX91, Mental retardation, X-linked type 91, ZDHHC15-associated intellectual disability

ZDHHC15 Gene Mental retardation, X-linked type 91 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The clinical report is typically issued within 3 to 4 weeks after the sample is received by the laboratory. Some complex variants requiring additional analysis may take longer.. Free home collection in 300+ cities across India.

NGS Genetic TestMale / Female (carrier testing)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the ZDHHC15 gene NGS genetic test is to detect pathogenic variants in the ZDHHC15 gene in individuals with suspected X-linked intellectual disability type 91 and to provide information for genetic counselling, recurrence risk assessment, and family planning.

Test Code
4295
CPT Code
81479
ICD Code
F79
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
The clinical report is typically issued within 3 to 4 weeks after the sample is received by the laboratory. Some complex variants requiring additional analysis may take longer.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required for this test. Patients should bring medical records, clinical history, and any available family pedigree to the genetic counselling session.

Method: Peripheral venipuncture / Dried blood spot

Step 2

Laboratory Analysis

A peripheral blood sample is collected in an EDTA vacutainer, or a dried blood spot is collected on an FTA card. The procedure is quick and carries minimal discomfort.

Step 3

Report Delivery

The sample is transported to the laboratory at appropriate temperature. The patient can resume normal activities immediately after collection.

Timeline: The clinical report is typically issued within 3 to 4 weeks after the sample is received by the laboratory. Some complex variants requiring additional analysis may take longer.

Patient Instructions

1
Before the Test:A genetic counselling session is recommended before the test to review the clinical history, draw a pedigree chart of affected family members, and explain the possible outcomes of the test.
2
During the Test:The collection process is usually simple. For a blood sample, your healthcare provider will draw blood from a vein in your arm. For an FTA card, a few drops of blood are placed on a special card. No anaesthesia is required.
3
After the Test:You can return to normal daily activities immediately after sample collection. The laboratory will process the sample using NGS technology and provide a conclusive clinical report along with raw data files, FASTQ, and VCF files as per DNA Labs India's transparency policy.

About This Test

Who Should Get This Test

The purpose of the ZDHHC15 gene NGS genetic test is to detect pathogenic variants in the ZDHHC15 gene in individuals with suspected X-linked intellectual disability type 91 and to provide information for genetic counselling, recurrence risk assessment, and family planning.

How to Prepare

  • No special dietary preparation or fasting is required.
  • Please carry previous medical records and a list of medications if available.
  • A signed consent form and genetic counselling session are recommended before sample collection.
  • The sample should be properly labelled with patient name, unique ID, and collection time.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic counselling before and after testing is important to help families understand the inheritance pattern, recurrence risk, and implications of a positive or negative result."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeWhole blood in EDTA tube / extracted DNA / one FTA card blood spot
ContainerEDTA vacutainer / FTA card
Collection MethodPeripheral venipuncture / Dried blood spot

Sample Stability

Whole blood in EDTA: 2–8°C for up to 72 hours.
Extracted DNA: -20°C or below for long-term storage.
FTA card blood spot: Room temperature (15–30°C) for several weeks.
Sample Rejection Criteria:
  • Clotted blood sample received in EDTA tube.
  • Sample without proper labelling or patient identification.
  • Grossly haemolysed sample or sample received in additive mismatch for NGS.
  • Insufficient quantity of DNA or blood for testing.

Understanding Your Results

This NGS genetic test is used to identify clinically significant variants in the ZDHHC15 gene. The result should be interpreted by a clinical geneticist in the context of the individual's symptoms, family history, and pedigree.
📊

Pathogenic or likely pathogenic variant detected

Supports a molecular diagnosis of ZDHHC15-associated X-linked mental retardation type 91 in males. Genetic counselling is recommended to discuss recurrence risk and family testing.

📊

No pathogenic variant detected

Does not confirm MRX91, but does not exclude all genetic causes. Further testing may be needed based on clinical findings.

📊

Variant of uncertain significance (VUS) detected

A genetic variant was found whose clinical significance is unclear. Segregation testing in family members and additional functional studies may help clarify its role.

⚠️ When to Consult a Doctor:

Consult a clinical geneticist or neurologist if the test result is positive, uncertain, or if symptoms suggest an inherited intellectual disability. Genetic counselling is also advised for couples planning a family with a history of X-linked mental retardation.

Limitations

  • ⚠This targeted test examines the ZDHHC15 gene only and does not rule out other genetic causes of intellectual disability.
  • ⚠A negative result does not exclude ZDHHC15-related MRX91 if a variant is in a region not covered or an uncharacterised non-coding variant is present.
  • ⚠Variants of uncertain significance may be reported and may require additional family segregation studies.
  • ⚠NGS is not validated for detection of large structural rearrangements, trinucleotide repeat disorders, or very low-level mosaicism.
  • ⚠Genetic test results should always be interpreted in the context of clinical findings and family history.

Risks & Considerations

  • ●The blood draw may cause minor pain, bruising, or bleeding at the puncture site.
  • ●Possible psychological stress from receiving a genetic diagnosis.
  • ●The test may not detect all disease-causing variants, which can lead to diagnostic uncertainty.
  • ●A variant of uncertain significance may require additional testing of family members.

Interfering Factors

  • ●Poor quality or degraded DNA sample.
  • ●PCR contamination or sample mix-up.
  • ●Incomplete coverage of clinically relevant exons.
  • ●Very rare non-coding or deep intronic variants that are not covered by targeted NGS.
  • ●Mosaic variants with very low allele frequency may be missed.

Compare With Similar Tests

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Frequently Asked Questions

What is the ZDHHC15 gene?
The ZDHHC15 gene is located on the X chromosome and provides instructions for making palmitoyltransferase ZDHHC15. This enzyme adds palmitate to certain proteins, which is important for their correct function, especially in nerve cells.
What is X-linked mental retardation type 91 (MRX91)?
MRX91 is a genetic condition caused by variants in the ZDHHC15 gene that affect palmitoylation and result in intellectual disability. It primarily affects males because it is X-linked.
Who should take this ZDHHC15 gene NGS genetic test?
This test is usually considered for males with unexplained intellectual disability, especially those with speech delay, behavioural issues, seizures, or a family history of X-linked intellectual disability.
What sample is needed for this test?
The sample can be whole blood in an EDTA tube, extracted DNA, or one drop of blood collected on an FTA card.
Do I need to fast before the test?
No, this test does not require fasting. You can follow your normal routine before sample collection.
What is the cost of the ZDHHC15 gene NGS genetic test at DNA Labs India?
The special discounted price for this test at DNA Labs India is INR 20,000. Free home sample collection is available for online bookings across many cities in India.
How long will it take to get the report?
The report is usually available within 3 to 4 weeks from the time the sample reaches the laboratory.
What does a positive test result mean?
If a pathogenic or likely pathogenic variant is identified in the ZDHHC15 gene, it provides a molecular diagnosis of ZDHHC15-associated X-linked mental retardation type 91 in the appropriate clinical context.
What does a negative test result mean?
A negative result means no pathogenic variant was detected in the ZDHHC15 gene. It does not exclude all genetic causes of intellectual disability, and further testing may be recommended.
Will this test detect all causes of intellectual disability?
No. This targeted NGS test only analyses the ZDHHC15 gene. Other genetic and non-genetic causes of intellectual disability may require a broader panel, chromosomal microarray, or whole exome sequencing.
Why is genetic counselling needed before this test?
Genetic counselling helps you understand the inheritance pattern, risks, benefits, limitations, and possible medical and psychological implications of genetic testing. It also helps prepare the family for result interpretation and recurrence risk assessment.
Will I receive the raw sequencing data files?
Yes. At DNA Labs India, the conclusive clinical report is shared along with raw data, FASTQ, and VCF files, making the laboratory transparent and enabling a second opinion if needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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