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ZFR Gene SPG71, ZFR related NGS Genetic Test

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ZFR Gene SPG71, ZFR related NGS Genetic Test

Short Name: ZFR Gene SPG71 Test

Also known as: Hereditary Spastic Paraplegia 71, ZFR-related spastic paraplegia, SPG71

ZFR Gene SPG71, ZFR related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS) Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the ZFR Gene SPG71 NGS Genetic Test is to detect mutations in the ZFR gene associated with Hereditary Spastic Paraplegia 71, enabling early diagnosis, informed management, and genetic counseling for affected individuals and their families.

Test Code
1826
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history of the patient, undergo a genetic counseling session to draw a pedigree chart of affected family members, and ensure no fasting is required.

Method: Venipuncture or FTA card spotting

Step 2

Laboratory Analysis

Blood sample collected via venipuncture into an EDTA tube or a drop spotted on an FTA card at ambient room temperature.

Step 3

Report Delivery

Label sample correctly, store at ambient temperature, and transport to the laboratory within 24 hours for processing.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Genetic counseling to discuss test implications, obtain informed consent, and collect clinical and family history.
2
During the Test:Sample collection via blood draw or FTA card, followed by NGS analysis in the laboratory.
3
After the Test:Wait for results in 3-4 weeks, receive report via chosen method, and follow up with genetic counseling for interpretation.

About This Test

Who Should Get This Test

The purpose of the ZFR Gene SPG71 NGS Genetic Test is to detect mutations in the ZFR gene associated with Hereditary Spastic Paraplegia 71, enabling early diagnosis, informed management, and genetic counseling for affected individuals and their families.

How to Prepare

  • Collect 5-10 ml of blood in an EDTA tube or spot one drop on an FTA card
  • Store samples at ambient room temperature
  • Transport to lab within 24 hours to ensure sample integrity

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing with NGS can guide diagnosis and management for patients presenting with symptoms of hereditary spastic paraplegia."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5-10 ml of blood or as per requirement
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card spotting

Sample Stability

EDTA blood: stable for 7 days at 2-8°C
FTA card: stable at room temperature for up to 30 days
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Incorrect container or labeling
  • Sample older than stability period

Understanding Your Results

Results from the ZFR Gene SPG71 NGS Genetic Test should be interpreted by a qualified geneticist or neurologist in the context of clinical findings and family history.
A negative result indicates no pathogenic variants detected in the ZFR gene
A positive result identifies mutations associated with SPG71, confirming diagnosis
Variants of uncertain significance require further evaluation and genetic counseling
⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms such as progressive walking difficulties, muscle stiffness, or neurological issues, especially with a family history of hereditary spastic paraplegia.

Limitations

  • ⚠May not detect all possible variants in the ZFR gene
  • ⚠Requires genetic counseling for result interpretation
  • ⚠Does not assess for other genetic conditions

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Psychological impact of genetic test results
  • ●Potential for uncertain findings requiring further testing

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Improper sample storage

Compare With Similar Tests

TestZFR Gene SPG71, ZFR related NGS Genetic TestSPG7 Gene TestHereditary Spastic Paraplegia PanelWhole Exome SequencingNeuropathy Gene Panel
ComparisonZFR Gene SPG71, ZFR related NGS Genetic Test

Frequently Asked Questions

What is ZFR Gene SPG71?
ZFR Gene SPG71 is a rare genetic disorder caused by mutations in the ZFR gene, leading to hereditary spastic paraplegia affecting the nervous system.
What are the common symptoms of ZFR Gene SPG71?
Symptoms include difficulty walking, muscle weakness, spasticity, numbness in extremities, vision problems, and cognitive impairment.
How is ZFR Gene SPG71 diagnosed?
Diagnosis involves clinical examination, genetic testing such as NGS to detect ZFR gene mutations, and imaging studies like MRI.
What is the cost of the NGS Genetic Test for ZFR Gene SPG71 in India?
The test costs INR 20000 at DNA Labs India, with free home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks from sample receipt.
What sample type is required for the ZFR Gene SPG71 test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
Is genetic counseling recommended before taking this test?
Yes, a genetic counseling session is recommended to draw a pedigree chart and discuss test implications.
What treatment options are available for ZFR Gene SPG71?
Treatment focuses on symptom management, physical therapy, and supportive care; early diagnosis aids in planning.
Is this test covered by insurance or government schemes?
Coverage depends on individual policies; check with insurance providers or schemes like PMJAY, CGHS, ECHS, ESIC for details.
Can this test detect all mutations in the ZFR gene?
While NGS is highly accurate, it may not detect all possible variants; genetic counseling can help interpret results.
How accurate is the NGS Genetic Test for ZFR Gene SPG71?
NGS technology provides high accuracy and precision for detecting genetic mutations, making it a reliable diagnostic tool.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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