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ZNF311 Gene Neurodevelopmental disorder, ZNF311 related NGS Genetic Test

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ZNF311 Gene Neurodevelopmental disorder, ZNF311 related NGS Genetic Test

Short Name: ZNF311 NGS Test

Also known as: ZNF311 Related NGS Genetic Test, ZNF311 Gene Sequencing, ZNF311 Mutation Analysis (NGS), Neurodevelopmental Disorder Genetic Panel (ZNF311)

ZNF311 Gene Neurodevelopmental disorder, ZNF311 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop blood on FTA Card samples. Results in Reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify pathogenic variants in the ZNF311 gene that may be associated with neurodevelopmental disorders, aiding in diagnosis, genetic counselling, and management planning.

Test Code
4406
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop blood on FTA Card
Result Time
Reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation such as fasting is required. A detailed clinical history and genetic counselling session to draw a pedigree chart of affected family members is advised before the sample is collected.

Method: Venipuncture, FTA card blood spot, or extracted DNA submission

Step 2

Laboratory Analysis

For blood samples, a routine venipuncture will be performed. A heel or finger-prick dried blood spot on an FTA card may also be accepted. The collection is quick and done using sterile equipment.

Step 3

Report Delivery

No post-collection restrictions are needed. The sample will be transported to the laboratory under ambient temperature conditions, and the report is generally available in 3 to 4 weeks.

Timeline: Reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:No fasting is required. A genetic counselling session is recommended to review the clinical history and draw a pedigree chart before the test is booked.
2
During the Test:The sample is collected by venipuncture or as a dried blood spot on an FTA card. The collection procedure usually takes only a few minutes.
3
After the Test:After sample collection, the sample is sent to the DNA Labs India facility for NGS analysis. Results are generally delivered in 3 to 4 weeks via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of this test is to identify pathogenic variants in the ZNF311 gene that may be associated with neurodevelopmental disorders, aiding in diagnosis, genetic counselling, and management planning.

How to Prepare

  • Sample type: blood in EDTA tube, extracted DNA, or one drop of blood on an FTA card
  • Pre-test genetic counselling to draw a pedigree chart is strongly recommended
  • Carry any previous genetic test reports or clinical records for correlation
  • Ensure the sample is labelled correctly with the patient's name and unique ID
  • Raw data, FASTQ, and VCF files will be shared along with the clinical report

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"A genetic test can clarify the aetiology of neurodevelopmental delay, but it should never replace clinical evaluation. Pre-test counselling and a complete three-generation pedigree are essential for accurate interpretation."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop blood on FTA Card
Sample Volume2-3 mL blood or 1 µg extracted DNA or 1 drop blood on FTA card
ContainerEDTA tube / DNA vial / FTA card
Collection MethodVenipuncture, FTA card blood spot, or extracted DNA submission

Sample Stability

Whole blood in EDTA: 3 days at ambient temperature
Extracted DNA: 1 week at 2-8°C
FTA card blood spot: stable for several weeks at ambient temperature
Sample Rejection Criteria:
  • Haemolysed or clotted blood sample
  • Unlabelled or mislabelled sample
  • Insufficient sample quantity
  • Sample not received in an appropriate EDTA tube, DNA vial, or FTA card
  • Missing consent or incomplete clinical history

Understanding Your Results

The result should be interpreted by a clinical geneticist in the context of clinical presentation, family history, and other investigations.
A pathogenic or likely pathogenic variant in ZNF311 may support the diagnosis of a ZNF311-related neurodevelopmental disorder.
A variant of uncertain significance (VUS) requires further segregation analysis, family studies, or functional evaluation.
No pathogenic variant detected does not rule out a genetic cause; additional testing may be considered based on clinical findings.
Benign or likely benign variants are not considered to be disease-causing.
⚠️ When to Consult a Doctor:

If the test result is positive, if a variant of uncertain significance is reported, or if symptoms persist despite a negative result, consult the referring physician or clinical geneticist for genetic counselling and further evaluation.

Limitations

  • ⚠NGS cannot detect all types of clinically significant variants, such as large structural rearrangements, repeat expansions, or copy number variants
  • ⚠Results may be inconclusive if a variant of uncertain significance is identified
  • ⚠A negative result does not exclude the diagnosis because another genetic or non-genetic cause may be present
  • ⚠Clinical interpretation is limited by incomplete knowledge of ZNF311 gene function and genotype-phenotype correlation
  • ⚠The test is not a substitute for a comprehensive neurology or genetics consultation

Risks & Considerations

  • ●Minimal pain or bruising at the blood collection site
  • ●Rare bleeding, infection, or haematoma
  • ●No radiation or chemical risk from NGS testing

Interfering Factors

  • ●Sample mix-up or contamination
  • ●Poor DNA quality or quantity
  • ●Variants of uncertain significance
  • ●Incomplete clinical or family history
  • ●Low sequencing coverage in certain gene regions

Compare With Similar Tests

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Frequently Asked Questions

What is the ZNF311 gene neurodevelopmental disorder NGS genetic test?
It is a next-generation sequencing test that analyses the ZNF311 gene to look for pathogenic variants that may be associated with neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, and developmental delay. It is performed on a blood, FTA card, or extracted DNA sample.
Which symptoms may indicate the need for this test?
Common symptoms include intellectual disability, delayed speech and language development, impaired social communication, repetitive behaviours, hyperactivity, impulsivity, anxiety, and depression. A clinical geneticist or neurologist may recommend testing after a detailed evaluation.
Why is NGS technology used?
NGS is a high-throughput sequencing method that can read multiple genes at once and detect a wide range of sequence variants. It provides a comprehensive analysis of the ZNF311 gene in a single test.
What is the cost of the test at DNA Labs India?
The special discounted price for the ZNF311 gene neurodevelopmental disorder NGS genetic test is INR 20,000. Free home sample collection is available for online bookings across India.
What sample types are accepted?
The test accepts blood, extracted DNA, or one drop of blood on an FTA card. The sample should be collected in an EDTA tube, FTA card, or DNA vial depending on the collection option.
Do I need to fast before the test?
No. Fasting is not required for this NGS genetic test. The sample can be collected at ambient room temperature without any special preparation.
How long does it take to get the report?
Reports are generally available in 3 to 4 weeks from the date the sample is received at the laboratory.
Is genetic counselling necessary before the test?
Yes. A genetic counselling session is recommended to draw a pedigree chart of affected family members and to discuss the benefits, limitations, and implications of genetic testing before the sample is collected.
What does 'no pathogenic variants detected' mean?
It means that no disease-causing sequence variants were identified in the ZNF311 gene in the tested sample. However, it does not completely exclude a genetic or non-genetic cause, and the result should be interpreted with clinical correlation.
What is a variant of uncertain significance (VUS)?
A VUS is a genetic change whose impact on health is not yet known. If a VUS is reported, additional family studies or further testing may be needed to determine whether it is clinically significant.
Will DNA Labs India provide raw data with the report?
Yes. DNA Labs India shares raw data, FASTQ, and VCF files along with the conclusive clinical report, providing transparency and allowing for secondary analysis or consultation.
Can this test be done for children?
Yes. The ZNF311 gene neurodevelopmental disorder NGS genetic test is suitable for both children and adults. Pre-test genetic counselling and parental consent are advised for paediatric testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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