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DNA Labs India

ZNF41 Gene Mental retardation, X-linked type 89 NGS Genetic Test

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ZNF41 Gene Mental retardation, X-linked type 89 NGS Genetic Test

Short Name: ZNF41 Gene Test

Also known as: ZNF41-related intellectual disability, X-linked mental retardation 89

ZNF41 Gene Mental retardation, X-linked type 89 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic TestMale🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect pathogenic mutations in the ZNF41 gene to confirm a diagnosis of mental retardation, X-linked type 89, guide clinical management, and provide genetic counseling for affected individuals and their families.

Test Code
4549
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Results are typically available within 3 to 4 weeks from sample receipt.
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and undergo genetic counseling if recommended.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm or a finger-prick for FTA card. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: Results are typically available within 3 to 4 weeks from sample receipt.

Patient Instructions

1
Before the Test:Genetic counseling to discuss test implications, benefits, and limitations. Provide informed consent and clinical history.
2
During the Test:Sample collection via blood draw or saliva. The test involves NGS sequencing in a certified laboratory.
3
After the Test:Wait for results (3-4 weeks). Follow-up with genetic counselor or physician to discuss findings and next steps.

About This Test

Who Should Get This Test

The purpose of this test is to detect pathogenic mutations in the ZNF41 gene to confirm a diagnosis of mental retardation, X-linked type 89, guide clinical management, and provide genetic counseling for affected individuals and their families.

How to Prepare

  • Use sterile equipment for blood collection
  • Label samples correctly with patient details
  • Store samples at ambient temperature if using FTA card
  • Transport to the laboratory within 24 hours for optimal stability

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for ZNF41 mutations can aid in accurate diagnosis, management, and family counseling for X-linked intellectual disability."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL blood or equivalent DNA
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood in EDTA tube: stable for 7 days at 2-8°C
FTA card: stable at room temperature for years
Extracted DNA: stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Incorrect labeling or missing patient information
  • Contaminated samples

Understanding Your Results

Results from the ZNF41 Gene NGS Genetic Test are interpreted based on the presence or absence of pathogenic mutations. A positive result indicates a genetic cause for the symptoms, while a negative result may require further testing or clinical evaluation.
📊

Pathogenic variant detected

Confirms diagnosis of X-linked mental retardation type 89. Genetic counseling and management planning are recommended.

📊

Likely pathogenic variant detected

Strong evidence for association with the condition. Further family studies may be advised.

📊

Variant of uncertain significance (VUS)

Insufficient evidence to determine clinical significance. Monitoring and additional testing may be needed.

📊

No pathogenic variants detected

ZNF41 mutations not identified. Consider other genetic or non-genetic causes for symptoms.

⚠️ When to Consult a Doctor:

Consult a doctor if you or a family member exhibit symptoms of intellectual disability, developmental delays, or seizures, especially with a family history of X-linked conditions. Genetic counseling is advised before and after testing.

Limitations

  • ⚠May not detect all types of mutations (e.g., large deletions/duplications if not covered by NGS)
  • ⚠Variants of uncertain significance (VUS) may require further investigation
  • ⚠Does not rule out other genetic causes of intellectual disability
  • ⚠Results should be correlated with clinical findings and family history

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, discomfort)
  • ●Potential psychological impact of genetic results
  • ●Risk of incidental findings or variants of uncertain significance

Interfering Factors

  • ●Poor sample quality (e.g., hemolyzed blood)
  • ●Contamination during sample collection or processing
  • ●Insufficient DNA quantity
  • ●Recent blood transfusions may affect results

Compare With Similar Tests

TestZNF41 Gene Mental retardation, X-linked type 89 NGS Genetic TestFMR1 Gene Test for Fragile X SyndromeMECP2 Gene Test for Rett SyndromeWhole Exome Sequencing (WES)Chromosomal Microarray Analysis
ComparisonZNF41 Gene Mental retardation, X-linked type 89 NGS Genetic TestTargets FMR1 gene mutations; different inheritance pattern and symptoms.Focuses on MECP2 gene; primarily affects females with distinct neurological features.Broader analysis of all genes; higher cost but may identify variants in multiple genes.Detects copy number variants; useful for broader genetic screening but not specific to ZNF41.

Frequently Asked Questions

What is the ZNF41 Gene Mental Retardation, X-linked type 89 NGS Genetic Test?
This test uses Next-Generation Sequencing to identify mutations in the ZNF41 gene, which is linked to X-linked intellectual disability type 89, helping in diagnosis and management.
Who should consider this genetic test?
Individuals with symptoms of intellectual disability, developmental delays, seizures, or a family history of X-linked mental retardation should consider this test, as advised by a healthcare provider.
How is the test performed?
The test involves collecting a blood or saliva sample, which is then analyzed using NGS technology to sequence the ZNF41 gene for any mutations.
What is the cost of the test?
The cost at DNA Labs India is INR 20000, which includes sequencing, a detailed report, and genetic counseling support.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India when booked online.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks from the date of sample collection.
What do the results indicate?
Results can show pathogenic variants confirming the diagnosis, variants of uncertain significance, or no variants detected, guiding further clinical decisions.
Is genetic counseling recommended?
Yes, genetic counseling before and after testing is advised to understand the implications, interpret results, and plan management.
Are there any risks associated with the test?
The test has minimal physical risks from blood draw, but there may be psychological impacts; discuss concerns with your doctor.
Can this test be used for carrier testing?
Yes, it can identify female carriers of ZNF41 mutations, which is important for family planning and genetic counseling.
What if the test result is negative?
A negative result means no pathogenic ZNF41 mutations were found, but symptoms may be due to other genetic or non-genetic factors; further evaluation may be needed.
How accurate is the NGS genetic test?
NGS technology is highly accurate for detecting mutations, but no test is 100% definitive; results should be correlated with clinical findings.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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