ZNF81 Gene Mental retardation, X-linked type 45 NGS Genetic Test
Short Name: ZNF81 MRX45 NGS Test
Also known as: MRX45, Mental retardation, X-linked type 45, ZNF81 gene mutation analysis
ZNF81 Gene Mental retardation, X-linked type 45 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect disease-causing variants in the ZNF81 gene in individuals presenting with features of MRX45, thereby providing a molecular diagnosis and helping family members understand recurrence risk.
- Test Code
- 4284
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. A genetic counselling session should be completed before the test to record clinical history, draw a pedigree chart, and explain the benefits and limitations of genetic testing.
Method: Venipuncture or dried blood spot on FTA card
Laboratory Analysis
An appropriate sample such as blood, FTA card blood spot, or extracted DNA is collected by a trained phlebotomist or as instructed by the laboratory.
Report Delivery
The sample is transported to the DNA laboratory for DNA extraction and NGS. No patient restrictions are needed after collection.
Timeline: Reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect disease-causing variants in the ZNF81 gene in individuals presenting with features of MRX45, thereby providing a molecular diagnosis and helping family members understand recurrence risk.
How to Prepare
- Book the test online for free home sample collection.
- Use the sample container provided by DNA Labs India.
- Label the sample clearly with patient name and date of birth.
- Complete the clinical history, requisition form, and genetic counselling documentation.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"For families with a known or suspected X-linked intellectual disability, reproductive planning and genetic counselling are important. Carrier testing in at-risk female relatives can clarify recurrence risks and guide future pregnancies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Hemolyzed or clotted blood
- Unlabeled or mislabeled sample
- Non-EDTA blood sample or contaminated FTA card
Understanding Your Results
Consult a clinical geneticist, neurologist, or pediatrician if there is unexplained developmental delay, intellectual disability, seizures, or a family history of X-linked intellectual disability.
Limitations
- ⚠This single-gene NGS test analyzes only the ZNF81 gene and cannot rule out other genetic or non-genetic causes of intellectual disability.
- ⚠Large deletions/duplications, deep intronic variants, and repeat expansions may not be detected by standard NGS.
- ⚠A variant of uncertain significance may require additional family studies and clinical correlation.
Risks & Considerations
- ●Mild bruising or pain at the blood collection site
- ●Emotional impact of a genetic diagnosis
- ●Privacy and insurance considerations
Interfering Factors
- ●Poor DNA quality or quantity
- ●Sample contamination
- ●Recent allogeneic stem cell transplant
- ●Maternal cell contamination of fetal samples, if applicable
Compare With Similar Tests
| Test | ZNF81 Gene Mental retardation, X-linked type 45 NGS Genetic Test | ||||
|---|---|---|---|---|---|
| Comparison | ZNF81 Gene Mental retardation, X-linked type 45 NGS Genetic Test |
Frequently Asked Questions
What is ZNF81-related mental retardation, X-linked type 45?
What is the cost of the ZNF81 gene NGS genetic test at DNA Labs India?
What sample is required for this test?
Is fasting required before the test?
How long will it take to get the report?
What conditions does this test screen for?
Who should consider this test?
Does this test detect all causes of intellectual disability?
What does a 'no pathogenic variant detected' result mean?
What is a variant of uncertain significance?
Can females have this condition?
Will I receive raw data, FASTQ, and VCF files with the report?
Related Tests
Angelman Syndrome Test
₹10,000Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test
₹14,000Episodic Ataxia Type 1 Hotspot Test
₹11,500Episodic Ataxia Comprehensive Profile Hotspot Test
₹16,000Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test
₹7,500Analyzer 18 SMA 18 Test Panel
₹1,755Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.