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ABCC2 Gene Dubin-Johnson syndrome NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

ABCC2 Gene Dubin-Johnson syndrome NGS Genetic Test

Also known as: Dubin-Johnson Syndrome Genetic Test, ABCC2 Mutation Analysis

ABCC2 Gene Dubin-Johnson syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose Dubin-Johnson Syndrome by detecting mutations in the ABCC2 gene using NGS technology, aiding in clinical management and genetic counseling.

Test Code
2580
Price
₹20,000
Sample Type
Blood
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree during genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample is drawn via venipuncture from a vein in the arm.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Attend a genetic counseling session to discuss family history and test implications.
2
During the Test:Blood sample collection takes about 10-15 minutes.
3
After the Test:Results are delivered online; follow up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

To diagnose Dubin-Johnson Syndrome by detecting mutations in the ABCC2 gene using NGS technology, aiding in clinical management and genetic counseling.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is essential for confirming Dubin-Johnson Syndrome, guiding management, and informing family planning through genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume5 mL
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Stable at room temperature for 48 hours
Refrigerate if delayed
Sample Rejection Criteria:
  • Hemolyzed or insufficient sample
  • Incorrect labeling
  • Contaminated sample

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the ABCC2 gene. A positive result confirms Dubin-Johnson Syndrome, while a negative result may require further testing if clinical suspicion remains.
📊

Positive for pathogenic variant

Confirms diagnosis of Dubin-Johnson Syndrome. Genetic counseling recommended.

📊

Negative for pathogenic variant

No mutations detected. Consider other causes of liver dysfunction.

📊

Variant of uncertain significance

Further testing or family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a geneticist or hepatologist if symptoms persist, for family planning advice, or to discuss test results and management options.

Limitations

  • ⚠May not detect all rare mutations
  • ⚠Results require clinical correlation
  • ⚠Not a substitute for comprehensive liver evaluation

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare infection risk
  • ●Emotional impact of results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality

Frequently Asked Questions

What is ABCC2 Gene Dubin-Johnson Syndrome?
It is a rare inherited liver disorder caused by mutations in the ABCC2 gene, leading to impaired bilirubin excretion and jaundice.
What are the common symptoms?
Symptoms include jaundice, fatigue, abdominal pain, dark urine, and itching, though some individuals may be asymptomatic.
How is the condition diagnosed?
Diagnosis involves genetic testing to identify ABCC2 gene mutations, supported by liver function tests and clinical evaluation.
What is NGS Genetic Test?
Next-Generation Sequencing (NGS) is a technology that analyzes DNA to detect genetic mutations efficiently and accurately.
What is the cost of this test?
The test costs INR 20000 at DNA Labs India, including testing, interpretation, and genetic counseling.
Is home sample collection available?
Yes, free home collection is offered for online bookings across India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is fasting required for the test?
No, fasting is not required for this genetic test.
Who should consider this test?
Individuals with symptoms of jaundice, family history of Dubin-Johnson Syndrome, or unexplained liver issues.
What does a positive result mean?
A positive result confirms Dubin-Johnson Syndrome, guiding management and genetic counseling.
Is genetic counseling included?
Yes, the test cost includes a session with a board-certified genetic counselor.
How accurate is the test?
NGS technology provides high accuracy, but results should be interpreted in clinical context by a healthcare provider.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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