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DNA Labs India

Criggler Najjar Syndrome Test

DNA Labs India | ISO 9001:2015 Certified

Criggler Najjar Syndrome Test

Also known as: Criggler-Najjar syndrome, CNS

Criggler Najjar Syndrome Test test available at DNA Labs India for ₹27,000. Uses Sanger Sequencing on Peripheral Blood samples. Results in 7-8 days. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Criggler Najjar Syndrome by identifying genetic mutations in the UGT1A1 gene that affect bilirubin conjugation in the liver. It helps in confirming the diagnosis, guiding treatment decisions, and providing information for family planning.

Test Code
2988
Price
₹27,000
Sample Type
Peripheral Blood
Result Time
7-8 days
Fasting Required
No
Method
Sanger Sequencing
Step 1

Sample Collection

Consult with a healthcare provider and obtain a prescription if required. Inform about any medications or recent transfusions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected from a vein in the arm using standard venipuncture technique.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless advised otherwise.

Timeline: 7-8 days

Patient Instructions

1
Before the Test:No specific preparation required, but prescription may be needed.
2
During the Test:Blood sample collection takes a few minutes.
3
After the Test:Results are available online after 7-8 days.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Criggler Najjar Syndrome by identifying genetic mutations in the UGT1A1 gene that affect bilirubin conjugation in the liver. It helps in confirming the diagnosis, guiding treatment decisions, and providing information for family planning.

How to Prepare

  • Ensure prescription is available if needed
  • Avoid strenuous activity before collection
  • Stay hydrated

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early diagnosis of Criggler Najjar Syndrome is crucial for managing bilirubin levels and preventing neurological complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypePeripheral Blood
Sample Volume2ml
ContainerEDTA Vacutainer
Collection MethodVenipuncture

Sample Stability

EDTA blood stable for 24 hours at room temperature
For longer storage, refrigerate at 2-8°C
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Incorrect container or labeling

Understanding Your Results

Results of the Criggler Najjar Syndrome genetic test indicate the presence or absence of mutations in the UGT1A1 gene. Positive results confirm the diagnosis, while negative results may require further testing if clinical suspicion remains high.
📊

Positive for pathogenic mutation

Confirms diagnosis of Criggler Najjar Syndrome. Genetic counseling and treatment planning are recommended.

📊

Negative for pathogenic mutation

No mutation detected. Consider other causes of jaundice or repeat testing if clinically indicated.

📊

Variant of uncertain significance

Further testing and family studies may be needed. Consult with a genetic specialist.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of jaundice, have a family history of the syndrome, or if test results are positive or uncertain.

Limitations

  • ⚠May not detect all rare mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Not a screening test for general population

Risks & Considerations

  • ●Minor bruising or pain at the blood draw site
  • ●Rare risk of infection

Interfering Factors

  • ●Recent blood transfusions may affect genetic analysis
  • ●Contaminated or hemolyzed blood samples
  • ●Medications that affect liver function

Compare With Similar Tests

TestCriggler Najjar SyndromeLiver Function TestBilirubin TestGenetic Panel for Liver Diseases
ComparisonCriggler Najjar Syndrome

Frequently Asked Questions

What is Criggler Najjar Syndrome?
Criggler Najjar Syndrome is a rare genetic disorder that affects the liver's ability to process bilirubin, leading to jaundice and potential neurological damage.
How is Criggler Najjar Syndrome diagnosed?
It is diagnosed through genetic testing, specifically Sanger Sequencing of the UGT1A1 gene, along with blood tests for bilirubin levels.
What are the symptoms of Criggler Najjar Syndrome?
Symptoms include jaundice, dark urine, abdominal pain, fatigue, loss of appetite, and weight loss. In severe cases, it can cause brain damage.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort but is generally not painful.
How long does it take to get results?
Results are typically available within 7-8 days after sample collection.
Is home collection available?
Yes, free home sample collection is available for online bookings across India.
What is the cost of the test?
The cost is INR 27000, which includes test, home collection, and report delivery.
Do I need a doctor's prescription?
A doctor's prescription is recommended but may not be required for all cases. Check with the lab for specific requirements.
Can the test be done during pregnancy?
Consult with a healthcare provider. The test can be done, but genetic counseling is advised.
What if the test is positive?
A positive result confirms Criggler Najjar Syndrome. Treatment options include phototherapy, medication, or liver transplantation, and genetic counseling is recommended.
Is the test covered by insurance?
Coverage depends on your insurance policy. Check with your provider for details.
How accurate is the test?
The test uses Sanger Sequencing, which is highly accurate for detecting known mutations in the UGT1A1 gene.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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