Skip to main content
DNA Labs India

ADA2 Gene Polyarteritis nodosa, childhood-onset NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

ADA2 Gene Polyarteritis nodosa, childhood-onset NGS Genetic Test

Short Name: ADA2 Gene PAN NGS Test

Also known as: DADA2 Genetic Test, Adenosine Deaminase 2 Deficiency Test, Childhood-onset PAN Genetic Test

ADA2 Gene Polyarteritis nodosa, childhood-onset NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)Pediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify pathogenic mutations in the ADA2 gene that cause childhood-onset Polyarteritis Nodosa, aiding in accurate diagnosis, treatment planning, and genetic counseling.

Test Code
5342
Price
₹20,000
Sample Type
Blood
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture from a vein in the arm.

Step 3

Report Delivery

Sample labeled and transported to the lab under controlled conditions.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review.
2
During the Test:Blood sample collection.
3
After the Test:Sample analysis and report generation.

About This Test

Who Should Get This Test

To identify pathogenic mutations in the ADA2 gene that cause childhood-onset Polyarteritis Nodosa, aiding in accurate diagnosis, treatment planning, and genetic counseling.

How to Prepare

  • No fasting required
  • Bring valid ID and doctor's prescription
  • Inform about any medications or recent transfusions

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This NGS test is essential for confirming ADA2 mutations in children with suspected PAN, enabling targeted therapy and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume5-10 mL
ContainerEDTA Tube
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at 2-8°C
Avoid hemolysis
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improperly labeled sample

Understanding Your Results

Results indicate the presence or absence of mutations in the ADA2 gene. A positive result confirms genetic predisposition to PAN, while a negative result may require further testing.
📊

Positive for pathogenic variant

Confirms ADA2 deficiency, associated with childhood-onset PAN. Genetic counseling and targeted treatment recommended.

📊

Negative for pathogenic variant

No mutations detected in ADA2 gene. Consider other genetic or non-genetic causes of symptoms.

📊

Variant of uncertain significance

Further testing and family studies may be needed to determine clinical significance.

⚠️ When to Consult a Doctor:

If you experience symptoms like persistent fever, abdominal pain, or skin rashes, or if there is a family history of PAN, consult a geneticist or rheumatologist.

Limitations

  • ⚠May not detect all possible mutations
  • ⚠Results require interpretation by a geneticist
  • ⚠Does not rule out other causes of vasculitis

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare risk of infection
  • ●Fainting or dizziness during blood draw

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Recent blood transfusion

Frequently Asked Questions

What is the ADA2 Gene Polyarteritis Nodosa NGS Genetic Test?
This test uses next-generation sequencing to detect mutations in the ADA2 gene, which are associated with childhood-onset Polyarteritis Nodosa, a rare autoimmune disorder.
Who should consider taking this test?
Children with symptoms of PAN such as fever, abdominal pain, skin rashes, or those with a family history of ADA2 deficiency or PAN.
How is the test performed?
A blood sample is collected and analyzed using NGS technology to identify genetic mutations in the ADA2 gene.
What is the cost of the test in India?
The test costs INR 20000, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How long does it take to receive the results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the test results indicate?
Results show whether pathogenic mutations in the ADA2 gene are present, which can confirm a diagnosis of childhood-onset PAN.
Is genetic counseling recommended before and after the test?
Yes, genetic counseling is advised to understand the implications of the test results and for family planning.
Are there any risks associated with the test?
The test involves a standard blood draw, which may cause minor bruising or discomfort, but serious risks are minimal.
Can this test diagnose other conditions besides PAN?
This test specifically targets ADA2 gene mutations related to PAN. For other conditions, different genetic tests may be required.
What if the test is negative but symptoms persist?
A negative result does not rule out PAN entirely. Further clinical evaluation and additional tests may be necessary.
How accurate is the NGS genetic test?
NGS is a highly accurate technology for detecting genetic mutations, but accuracy depends on sample quality and interpretation by experts.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

MMC (Maternal Myopathy with Cardiomyopathy) Mutation Detection Test

₹11,500

LPA Gene Coronary artery disease, susceptibility to NGS Genetic Test

₹20,000

ITIH4 Gene Hypercholesterolemia, susceptibility to NGS Genetic Test

₹20,000

PPP1R17 Gene Hypercholesterolemia, susceptibility to NGS Genetic Test

₹20,000

APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test

₹20,000

GJC2 Gene Lymphedema, hereditary, type IC NGS Genetic Test

₹20,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.