LPA Gene Coronary artery disease, susceptibility to NGS Genetic Test
Short Name: LPA Gene CAD NGS Test
Also known as: LPA Gene Variant Analysis, Lipoprotein(a) Gene Sequencing, LPA NGS Sequencing Test, Coronary Artery Disease Genetic Susceptibility Test
LPA Gene Coronary artery disease, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks from sample collection. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the LPA Gene Coronary Artery Disease Susceptibility NGS Genetic Test is to identify genetic variants in the LPA gene that may be associated with an elevated risk of developing coronary artery disease. This test uses next-generation sequencing technology to detect variants that influence lipoprotein(a) levels and atherosclerotic plaque formation. The results help clinicians assess an individual's genetic predisposition to CAD, guide preventive strategies, and inform decisions regarding lipid-lowering therapies, lifestyle modifications, and cardiac monitoring.
- Test Code
- 1961
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks from sample collection
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
A genetic counselling session is recommended prior to sample collection to draw a pedigree chart of family members affected with coronary artery disease and to discuss the implications of genetic testing.
Method: Venipuncture / FTA Card
Laboratory Analysis
A blood sample of 3-5 mL will be collected via venipuncture into an EDTA tube, or alternatively a drop of blood can be collected on an FTA card. The procedure takes approximately 5-10 minutes.
Report Delivery
The sample will be transported to the laboratory under appropriate conditions. Results will be available within 3 to 4 weeks. A genetic counselling session is recommended post-testing to interpret the results and discuss next steps.
Timeline: 3 to 4 Weeks from sample collection
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the LPA Gene Coronary Artery Disease Susceptibility NGS Genetic Test is to identify genetic variants in the LPA gene that may be associated with an elevated risk of developing coronary artery disease. This test uses next-generation sequencing technology to detect variants that influence lipoprotein(a) levels and atherosclerotic plaque formation. The results help clinicians assess an individual's genetic predisposition to CAD, guide preventive strategies, and inform decisions regarding lipid-lowering therapies, lifestyle modifications, and cardiac monitoring.
How to Prepare
- No fasting is required prior to sample collection
- Maintain the blood sample at ambient room temperature during transport
- Ensure the EDTA tube is properly labeled with patient details
- If using an FTA card, allow the blood drop to dry completely before packaging
- Bring relevant clinical history and family pedigree information if available
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic variants in the LPA gene can significantly influence an individual's lifetime risk of coronary artery disease. NGS-based testing allows us to identify these variants early, enabling preventive strategies such as lifestyle modifications, lipid-lowering therapies, and closer cardiac monitoring. I recommend this test for patients with a strong family history of premature CAD or unexplained elevated cardiovascular risk despite normal lipid profiles."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received without proper labeling or patient identification
- Insufficient sample volume for DNA extraction
- Severely hemolyzed or contaminated blood sample
- Sample received in a leaking or damaged container
- Sample collected in incorrect anticoagulant tube (non-EDTA)
Understanding Your Results
No clinically significant variant in the LPA gene was identified. This result does not eliminate CAD risk, as environmental factors and other genetic variants may still contribute.
Standard CAD risk management based on conventional risk factors
A variant associated with increased Lp(a) levels and CAD risk was identified in one copy of the LPA gene. This may indicate an elevated genetic susceptibility to coronary artery disease.
Enhanced cardiovascular monitoring, lipid management, and preventive interventions recommended
A variant associated with increased Lp(a) levels and CAD risk was identified in both copies of the LPA gene. This may indicate a significantly elevated genetic susceptibility to coronary artery disease.
Aggressive cardiovascular risk reduction strategies, specialist cardiac monitoring, and family screening recommended
A genetic change in the LPA gene was identified, but current evidence is insufficient to classify it as pathogenic or benign. Further evaluation and periodic reclassification may be needed.
Clinical correlation required; consider repeat analysis or additional testing as new evidence becomes available
Consult your healthcare provider or cardiologist if your test results indicate the presence of a pathogenic or likely pathogenic variant in the LPA gene. Additionally, seek medical advice if you have a family history of premature coronary artery disease, are experiencing symptoms such as chest pain, shortness of breath, or fatigue, or wish to discuss preventive strategies and treatment options based on your genetic risk profile.
Limitations
- ⚠This test identifies variants in the LPA gene only and does not assess all genetic contributors to coronary artery disease
- ⚠Detection of a pathogenic variant indicates increased susceptibility but does not confirm that CAD will develop
- ⚠A negative result does not eliminate the risk of CAD, as environmental and other genetic factors also contribute
- ⚠Some variants of uncertain significance (VUS) may be detected, which require periodic reclassification as new evidence emerges
- ⚠This test is not a diagnostic test for coronary artery disease and should be used alongside clinical evaluation
Risks & Considerations
- ●Minor bruising or discomfort at the venipuncture site
- ●Very small risk of infection at the blood draw site
- ●Emotional impact of genetic risk information — genetic counselling is recommended
Interfering Factors
- ●Recent blood transfusions may affect DNA analysis results
- ●Contaminated or degraded DNA samples may yield inconclusive results
- ●Hemolyzed blood samples may impact DNA extraction quality
- ●Use of certain anticoagulants other than EDTA may interfere with sample processing
Compare With Similar Tests
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Frequently Asked Questions
What is the LPA Gene Coronary Artery Disease NGS Genetic Test?
Who should consider taking this test?
What sample is required for this test?
How long does it take to get the results?
What does it mean if a pathogenic variant is detected in the LPA gene?
Does a negative result mean I will not develop coronary artery disease?
Is genetic counselling included with this test?
What is lipoprotein(a) or Lp(a)?
Is this test covered by insurance in India?
Is home sample collection available for this test?
Can this test diagnose coronary artery disease?
What should I do if my results show an increased genetic risk for CAD?
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