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RYR2 Gene Arrhythmogenic right ventricular dysplasia type 2 NGS Genetic Test

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RYR2 Gene Arrhythmogenic right ventricular dysplasia type 2 NGS Genetic Test

Short Name: RYR2 ARVD2 NGS Test

Also known as: ARVD2, Arrhythmogenic Right Ventricular Dysplasia Type 2, RYR2-related ARVD

RYR2 Gene Arrhythmogenic right ventricular dysplasia type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the RYR2 gene associated with Arrhythmogenic Right Ventricular Dysplasia Type 2 (ARVD2) for diagnostic confirmation, risk assessment, and family screening.

Test Code
2485
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with ARVD2.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard blood draw procedure using aseptic technique.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Keep the area clean.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review.
2
During the Test:Blood sample collection and DNA extraction for NGS analysis.
3
After the Test:Report generation and genetic counseling for result interpretation.

About This Test

Who Should Get This Test

To identify mutations in the RYR2 gene associated with Arrhythmogenic Right Ventricular Dysplasia Type 2 (ARVD2) for diagnostic confirmation, risk assessment, and family screening.

How to Prepare

  • Fast for 8-12 hours if specified, but not required for this test.
  • Bring identification and doctor's prescription.
  • Inform about any medications or health conditions.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for RYR2 gene mutations is essential for confirming ARVD2 diagnosis and guiding treatment plans to prevent life-threatening arrhythmias."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples stable at 2-8°C for 72 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the RYR2 gene. A positive result confirms ARVD2 diagnosis, while a negative result may require further testing.
📊

Pathogenic variant detected

Confirms diagnosis of ARVD2. Recommend clinical evaluation and family screening.

📊

No pathogenic variant detected

ARVD2 unlikely, but clinical correlation is advised. Consider other genetic or non-genetic causes.

📊

Variant of uncertain significance

Further testing and family studies may be needed. Consult a genetic counselor.

⚠️ When to Consult a Doctor:

If you experience symptoms like chest pain, palpitations, or fainting, or have a family history of ARVD2 or sudden cardiac death, consult a cardiologist or genetic specialist.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results may have variants of uncertain significance

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA

Compare With Similar Tests

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ComparisonRYR2 Gene Arrhythmogenic right ventricular dysplasia type 2 NGS Genetic Test

Frequently Asked Questions

What is the RYR2 Gene ARVD2 NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to detect mutations in the RYR2 gene associated with Arrhythmogenic Right Ventricular Dysplasia Type 2 (ARVD2).
Who should get this test?
Individuals with symptoms of ARVD2 such as chest pain, palpitations, or fainting, or those with a family history of ARVD2 or sudden cardiac death.
How is the test performed?
A blood sample is collected and analyzed using NGS technology to identify mutations in the RYR2 gene.
What is the cost of the test?
The cost is INR 20,000 at DNA Labs India, which includes sample collection and analysis.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks.
What do the results mean?
A positive result indicates a pathogenic mutation in the RYR2 gene, confirming ARVD2. A negative result suggests no mutation, but clinical correlation is advised.
Is genetic counseling included?
Yes, a genetic counseling session is recommended before and after the test to discuss results and implications.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising or infection. Psychological impact of results should be considered.
Can this test be used for family screening?
Yes, if a mutation is identified, family members can be tested for early detection and management.
What is the accuracy of the test?
NGS provides high sensitivity and accuracy for detecting mutations, but may not identify all types of genetic variations.
How do I prepare for the test?
No fasting is required. Provide clinical history and attend a genetic counseling session for pedigree analysis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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