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APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test

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APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test

Short Name: APOA1 NGS Genetic Test

Also known as: APOA1 Gene Test, Hypoalphalipoproteinemia Genetic Test, APOA1 Mutation Analysis

APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect pathogenic mutations in the APOA1 gene associated with hypoalphalipoproteinemia, enabling diagnosis and risk assessment for cardiovascular diseases. This test aids in genetic counseling, family planning, and personalized management strategies.

Test Code
2115
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Results are typically available within 3 to 4 weeks from sample receipt.
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation is required. Ensure accurate patient identification and provide clinical history as needed.

Method: Venipuncture or blood drop collection

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample from a vein in the arm, or a blood drop on an FTA card, using sterile techniques.

Step 3

Report Delivery

Apply gentle pressure to the puncture site with a cotton ball to stop bleeding. Keep the area clean and dry.

Timeline: Results are typically available within 3 to 4 weeks from sample receipt.

Patient Instructions

1
Before the Test:Ensure genetic counseling session is scheduled to discuss family history and test implications. No fasting required.
2
During the Test:Sample collection involves a simple blood draw or blood drop, taking only a few minutes.
3
After the Test:Wait for 3-4 weeks for results. Results will be delivered via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

To detect pathogenic mutations in the APOA1 gene associated with hypoalphalipoproteinemia, enabling diagnosis and risk assessment for cardiovascular diseases. This test aids in genetic counseling, family planning, and personalized management strategies.

How to Prepare

  • Verify patient identity and test details
  • Use appropriate collection tubes or FTA cards
  • Label samples correctly to avoid mix-ups
  • Transport samples at ambient temperature to the lab promptly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is vital for identifying individuals with hypoalphalipoproteinemia, which increases cardiovascular risk due to low HDL cholesterol. Early detection through genetic testing allows for proactive management and lifestyle interventions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerVacutainer tube or FTA card
Collection MethodVenipuncture or blood drop collection

Sample Stability

Blood samples: Stable for 24-48 hours at room temperature
Extracted DNA: Stable for several days at 4°C or long-term at -20°C
FTA card: Stable for years if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Incorrect or missing labeling
  • Insufficient sample volume
  • Samples not stored or transported as instructed

Understanding Your Results

Results of the APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test indicate the presence or absence of mutations in the APOA1 gene. A positive result may confirm a diagnosis of hypoalphalipoproteinemia and increased cardiovascular risk, while a negative result suggests no detected pathogenic variants, though other factors may contribute to low HDL levels.
📊

Positive for pathogenic variant

Confirms diagnosis of hypoalphalipoproteinemia. Recommend genetic counseling, cardiovascular risk assessment, and lifestyle modifications.

📊

Negative for pathogenic variant

No mutation detected in APOA1 gene. Low HDL may be due to other genetic or environmental factors; further evaluation may be needed.

📊

Variant of uncertain significance (VUS)

Genetic variant found but not clearly linked to disease. Recommend periodic follow-up and family studies if possible.

⚠️ When to Consult a Doctor:

Consult a healthcare provider if test results indicate mutations or if you have symptoms of cardiovascular disease, a family history of hypoalphalipoproteinemia, or persistently low HDL levels. Genetic counseling is advised for interpretation and management planning.

Limitations

  • ⚠May not detect all possible genetic variants due to technical limitations of NGS
  • ⚠Results require interpretation by a geneticist or qualified healthcare provider
  • ⚠Does not rule out other causes of low HDL or cardiovascular risk
  • ⚠Genetic findings may have psychological implications and require counseling

Risks & Considerations

  • ●Minimal risk from blood draw, such as slight pain or bruising at the puncture site
  • ●Potential psychological impact of genetic results, including anxiety
  • ●Risk of misinterpretation without proper genetic counseling

Interfering Factors

  • ●Sample contamination during collection or processing
  • ●Insufficient DNA quality or quantity
  • ●Use of certain medications that may affect lipid metabolism (consult physician)
  • ●Hemolyzed or improperly stored samples

Compare With Similar Tests

TestAPOA1 Gene Hypoalphalipoproteinemia NGS Genetic TestLipid Profile TestAPOB Gene Mutation TestCardiovascular Risk Genetic Panel
ComparisonAPOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test

Frequently Asked Questions

What is the APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test?
It is a genetic test using next-generation sequencing (NGS) to detect mutations in the APOA1 gene, which causes hypoalphalipoproteinemia, a condition with low HDL cholesterol and increased cardiovascular risk.
Why should I consider this genetic test?
If you have low HDL cholesterol, a family history of cardiovascular disease, or symptoms like chest pain, this test can identify genetic mutations to assess your risk and guide management.
What are the symptoms of hypoalphalipoproteinemia?
Often asymptomatic, but may include high cholesterol or triglycerides, chest pain, shortness of breath, fatigue, or numbness in extremities, indicating potential cardiovascular issues.
How is the test performed?
The test involves collecting a blood sample or blood drop on an FTA card, which is then analyzed in the lab using NGS technology to sequence the APOA1 gene.
What type of sample is required?
You can provide a blood sample drawn from a vein, extracted DNA, or one drop of blood on an FTA card, as specified by DNA Labs India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
What is the cost of the test?
The APOA1 Gene Hypoalphalipoproteinemia NGS Genetic Test costs INR 20000 at DNA Labs India, which includes sample collection and analysis.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in multiple cities across India.
What does a positive result mean?
A positive result indicates the presence of a pathogenic mutation in the APOA1 gene, confirming hypoalphalipoproteinemia and a higher risk of cardiovascular disease. Genetic counseling is recommended.
What should I do if I have a mutation?
Consult a healthcare provider or geneticist for personalized advice, which may include lifestyle changes, monitoring, and potential treatments to manage cardiovascular risk.
Is the test covered by insurance?
Coverage varies by insurance provider and plan. Genetic tests are often not covered; check with your insurer or government schemes like PMJAY, CGHS, etc.
How can I book the test?
You can book the test online through the DNA Labs India website or contact them via phone or WhatsApp for assistance and home sample collection scheduling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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