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Alpha-1-Antitrypsin (AAT) Phenotype Test

DNA Labs India | ISO 9001:2015 Certified

Alpha-1-Antitrypsin (AAT) Phenotype Test

Short Name: AAT Phenotype Test

Also known as: Alpha-1 Antitrypsin Phenotyping, AAT Phenotyping, Alpha-1 Antitrypsin Deficiency Test

Alpha-1-Antitrypsin (AAT) Phenotype Test test available at DNA Labs India for ₹18,000. Uses Isoelectrofocusing on Serum samples. Results in Reports available after 2-3 weeks from sample submission.. Free home collection in 300+ cities across India.

Blood TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the AAT phenotype test is to diagnose Alpha-1-Antitrypsin deficiency by measuring the level and type of AAT protein in the blood. It is ordered for individuals with symptoms of lung disease or a family history of AAT deficiency to determine the severity of the condition and inform treatment plans.

Test Code
86
Price
₹18,000
Sample Type
Serum
Result Time
Reports available after 2-3 weeks from sample submission.
Fasting Required
No
Method
Isoelectrofocusing
Step 1

Sample Collection

Ensure consent form is filled and signed.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard venipuncture procedure.

Step 3

Report Delivery

Apply pressure to puncture site to stop bleeding.

Timeline: Reports available after 2-3 weeks from sample submission.

Patient Instructions

1
Before the Test:No special preparation needed, but ensure consent form is completed.
2
During the Test:A blood sample will be drawn from your vein.
3
After the Test:You can resume normal activities. Monitor for any bruising at the puncture site.

About This Test

Who Should Get This Test

The purpose of the AAT phenotype test is to diagnose Alpha-1-Antitrypsin deficiency by measuring the level and type of AAT protein in the blood. It is ordered for individuals with symptoms of lung disease or a family history of AAT deficiency to determine the severity of the condition and inform treatment plans.

How to Prepare

  • Fill and submit Test Send Out Consent Form (Form 35)
  • Sample must be refrigerated or frozen after collection

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This phenotype test is essential for early diagnosis of AAT deficiency, especially in families with a history of liver or lung disease."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL
ContainerRed Top (No Additive) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature6 hours
Refrigerator1 week
Frozen4 weeks
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed sample
  • Improper labeling

Understanding Your Results

Results of the AAT phenotype test indicate the presence and type of Alpha-1-Antitrypsin protein in the blood.
📊

Normal AAT levels and function

📊

Intermediate deficiency, may require monitoring

📊

Severe deficiency, high risk for lung and liver disease

⚠️ When to Consult a Doctor:

If test results indicate AAT deficiency or if symptoms persist, consult a pulmonologist or geneticist.

Limitations

  • ⚠May not detect all deficiency variants
  • ⚠Requires clinical correlation

Risks & Considerations

  • ●Minor bruising
  • ●Slight pain at puncture site
  • ●Rare infection risk

Interfering Factors

  • ●Acute inflammation
  • ●Liver disease
  • ●Certain medications

Compare With Similar Tests

TestAlpha-1-Antitrypsin (AAT) Phenotype Test
ComparisonAlpha-1-Antitrypsin (AAT) Phenotype Test

Frequently Asked Questions

What is the AAT phenotype test?
The AAT phenotype test is a blood test that measures the level and type of Alpha-1-Antitrypsin protein in the blood to diagnose AAT deficiency.
Why is the AAT phenotype test done?
It is done to diagnose AAT deficiency, especially in individuals with symptoms of lung disease like emphysema or COPD, or those with a family history of the condition.
How is the AAT phenotype test performed?
A blood sample is drawn from a vein and analyzed using isoelectrofocusing to determine AAT protein levels and phenotype.
What are the symptoms of AAT deficiency?
Symptoms include shortness of breath, wheezing, chest tightness, frequent respiratory infections, and coughing up blood.
What is the cost of the AAT phenotype test in India?
The cost is Rs 18000, with free home sample collection available across India.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection for the AAT phenotype test in many cities.
How long does it take to get the results?
Results are typically available after 2-3 weeks from sample submission.
What do the results of the AAT phenotype test mean?
Results indicate the type of AAT protein, such as MM (normal) or other phenotypes that may indicate deficiency.
Who should take the AAT phenotype test?
Individuals with symptoms of lung disease, a family history of AAT deficiency, or suspected genetic disorders should consider this test.
Are there any risks associated with the test?
Risks are minimal and may include minor bruising or slight pain at the puncture site.
How accurate is the AAT phenotype test?
The test is accurate for identifying AAT phenotypes when performed correctly, but clinical correlation is recommended.
What is the difference between the AAT level test and phenotype test?
The AAT level test measures only the protein amount, while the phenotype test identifies the specific type of AAT protein present.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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