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DNA Labs India

DNAAF3 Gene Primary ciliary dyskinesia type 2 NGS Genetic Test

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DNAAF3 Gene Primary ciliary dyskinesia type 2 NGS Genetic Test

Also known as: PCD Type 2, DNAAF3-related Primary Ciliary Dyskinesia

DNAAF3 Gene Primary ciliary dyskinesia type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify pathogenic mutations in the DNAAF3 gene using next-generation sequencing (NGS) technology, enabling definitive diagnosis of Primary Ciliary Dyskinesia type 2, guiding treatment strategies, and facilitating carrier testing for family planning.

Test Code
4774
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and undergo genetic counseling if needed.

Method: Venipuncture or blood drop

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or a blood drop on FTA card by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store sample as per instructions.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling. No fasting required.
2
During the Test:Blood sample collection via venipuncture or blood drop on FTA card.
3
After the Test:Apply pressure to puncture site. Await results in 3-4 weeks.

About This Test

Who Should Get This Test

The purpose of this test is to identify pathogenic mutations in the DNAAF3 gene using next-generation sequencing (NGS) technology, enabling definitive diagnosis of Primary Ciliary Dyskinesia type 2, guiding treatment strategies, and facilitating carrier testing for family planning.

How to Prepare

  • Ensure proper labeling of sample
  • Use sterile collection equipment
  • Transport sample at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This NGS genetic test is essential for confirming PCD type 2 diagnosis, guiding treatment, and enabling family planning through carrier identification."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or blood drop

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improperly labeled sample

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the DNAAF3 gene. Positive results confirm PCD type 2, while negative results may require further testing if clinical suspicion remains.
📊

Pathogenic variant detected

Confirms diagnosis of PCD type 2. Genetic counseling recommended for family planning.

📊

No pathogenic variant detected

PCD type 2 unlikely, but clinical correlation and additional tests may be needed.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience chronic respiratory symptoms, recurrent infections, or have a family history of PCD.

Limitations

  • ⚠May not detect all genetic variants, including deep intronic mutations
  • ⚠Requires genetic counseling for interpretation and family planning

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Hemolyzed blood sample

Frequently Asked Questions

What is Primary Ciliary Dyskinesia type 2?
PCD type 2 is a rare genetic disorder caused by mutations in the DNAAF3 gene, leading to impaired cilia function and chronic respiratory issues.
What are the symptoms of PCD type 2?
Symptoms include chronic cough, respiratory infections, sinusitis, ear infections, shortness of breath, nasal congestion, fatigue, pneumonia, wheezing, and difficulty breathing.
How is PCD type 2 diagnosed?
Diagnosis involves clinical evaluation, imaging studies like HRCT scans, and genetic testing such as NGS to identify DNAAF3 gene mutations.
What is the role of the DNAAF3 gene?
The DNAAF3 gene encodes a protein essential for cilia assembly and function; mutations disrupt mucus clearance, causing PCD symptoms.
What is NGS genetic testing?
Next-generation sequencing (NGS) is a advanced method to analyze multiple genes simultaneously, detecting mutations in the DNAAF3 gene for PCD type 2 diagnosis.
What is the cost of the DNAAF3 Gene NGS Genetic Test in India?
The cost is approximately INR 20,000 at DNA Labs India, with free home sample collection available.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
Is this test covered by insurance?
Coverage depends on your insurance plan; it is not universally covered. Check with your provider for details.
Who should consider taking this test?
Individuals with chronic respiratory symptoms, recurrent infections, or a family history of PCD should consider this test.
What are the risks of this genetic test?
Risks are minimal, primarily related to blood draw, such as bruising or infection at the puncture site.
How should I prepare for the test?
No special preparation is needed. Provide your clinical history and undergo genetic counseling if recommended.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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