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DNA Labs India

Antiphospholipid Antibody APLA Profile Test

DNA Labs India | ISO 9001:2015 Certified

Antiphospholipid Antibody APLA Profile Test

Short Name: APLA Panel Test

Also known as: APLA Test, Antiphospholipid Antibody Panel

Antiphospholipid Antibody APLA Profile Test test available at DNA Labs India for ₹5,000. Uses Chemiluminescence Immunoassay (CLIA), ELISA reflex confirmation on Serum samples. Results in 24-48 hours from sample pickup.. Free home collection in 300+ cities across India.

Immunological TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose antiphospholipid syndrome by detecting antiphospholipid antibodies, which are associated with thrombosis and pregnancy complications.

Test Code
164
Price
₹5,000
Sample Type
Serum
Result Time
24-48 hours from sample pickup.
Fasting Required
No
Method
Chemiluminescence Immunoassay (CLIA), ELISA reflex confirmation
Step 1

Sample Collection

No fasting required. Inform the lab about any anticoagulant use (e.g., warfarin, heparin) or recent illnesses.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm using standard venipuncture procedure.

Step 3

Report Delivery

The sample will be handled with cold-chain protocols and transported to the lab at 2-8°C for analysis.

Timeline: 24-48 hours from sample pickup.

Patient Instructions

1
Before the Test:No special preparation is needed. Avoid anticoagulant medications if advised by your doctor.
2
During the Test:A phlebotomist will draw a small blood sample from your arm. The process takes a few minutes.
3
After the Test:You can resume normal activities immediately. Apply pressure to the puncture site to prevent bruising.

About This Test

Who Should Get This Test

To diagnose antiphospholipid syndrome by detecting antiphospholipid antibodies, which are associated with thrombosis and pregnancy complications.

How to Prepare

  • No fasting required
  • Use a clot activator tube or plain vial for collection
  • Maintain sample at 2-8°C immediately after collection
  • Ensure proper labeling of the sample

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Order APLA panel for recurrent pregnancy loss, thrombosis under 50, or prolonged aPTT. Confirm with repeat testing after 12 weeks for persistent positivity."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
ContainerClot activator tube or plain vial
Collection MethodVenipuncture

Sample Stability

Stable for 8 hours at 2-8°C when cold-chain is maintained
Sample Rejection Criteria:
  • Hemolyzed or lipemic samples
  • Improperly labeled or stored samples
  • Samples with insufficient volume

Understanding Your Results

APLA test results help diagnose antiphospholipid syndrome. Positive results for one or more antibodies indicate a higher risk of thrombosis and pregnancy complications.
Positive results for lupus anticoagulant, aCL, or anti-β2GPI may suggest APS
Confirm with repeat testing ≥12 weeks apart to differentiate transient from persistent positivity
Correlate with clinical history (e.g., thrombosis, pregnancy loss) for diagnosis
Negative results do not completely rule out APS if clinical suspicion is high
⚠️ When to Consult a Doctor:

Consult a rheumatologist or haematologist if you experience recurrent pregnancy loss, unexplained thrombosis, or prolonged aPTT without bleeding.

Limitations

  • ⚠Single positive test may not confirm APS; repeat testing required after 12 weeks
  • ⚠Transient elevations possible due to infections or medications
  • ⚠Results may be affected by pre-analytical variability if cold-chain is not maintained

Risks & Considerations

  • ●Slight pain or bruising at the puncture site
  • ●Rare risk of infection or excessive bleeding

Interfering Factors

  • ●Anticoagulant therapy (e.g., warfarin, heparin)
  • ●Recent infections or vaccinations
  • ●Certain medications (e.g., antibiotics, phenothiazines)

Compare With Similar Tests

TestAntiphospholipid Antibody APLA Profile Test
ComparisonAntiphospholipid Antibody APLA Profile Test

Frequently Asked Questions

Why is APLA testing repeated after 12 weeks?
Antiphospholipid syndrome requires persistent positivity of antibodies at least twice, 12 weeks apart, to differentiate transient from true pathogenic antibodies. DNA Labs India offers a structured repeat test plan with clinical correlation.
Can I book an APLA test at home in Hyderabad or Bangalore?
Yes, DNA Labs India provides free home sample collection across 300+ cities including Hyderabad, Bangalore, Delhi, Mumbai, and Chennai. A trained phlebotomist follows cold-chain logistics.
How does the price at DNA Labs India compare to major hospital chains?
Major hospital chains charge ?5,500–?8,200 for an APLA panel, whereas DNA Labs India offers the same CLIA-based panel for ?5,000 – a 35-45% saving without compromising quality.
What is the clinical sensitivity of CLIA vs ELISA for anti-?2GPI?
CLIA achieves 96.4% sensitivity for anti-?2GPI antibodies compared to 84.2% for ELISA, reducing false negatives in obstetric APS. DNA Labs India uses automated CLIA for superior accuracy.
What is Antiphospholipid Syndrome (APS)?
APS is an autoimmune disorder where antiphospholipid antibodies increase the risk of blood clots (thrombosis) and pregnancy complications like recurrent miscarriage.
What are the common symptoms of APS?
Symptoms include recurrent pregnancy loss, blood clots in veins or arteries (e.g., DVT, stroke), thrombocytopenia, and skin rashes like livedo reticularis.
How is the APLA panel test performed?
A blood sample is collected via venipuncture and analyzed using CLIA technology to detect lupus anticoagulant, anticardiolipin, and anti-?2 glycoprotein I antibodies.
What do positive APLA test results mean?
Positive results indicate the presence of antiphospholipid antibodies, which may suggest APS, but diagnosis requires correlation with clinical history and repeat testing.
Is any preparation required before the APLA test?
No fasting or special preparation is needed. However, inform the lab about anticoagulant use, as it may affect certain parameters.
How accurate is the APLA test at DNA Labs India?
DNA Labs India uses ISO-certified CLIA technology with analytical sensitivity ?99.2%, reducing false negatives by 23% compared to standard ELISA.
Can I take the APLA test if I am pregnant?
Yes, the test can be performed during pregnancy, especially for women with recurrent pregnancy loss. Consult your doctor for appropriate timing.
What is the cost of repeat APLA testing for confirmation?
DNA Labs India offers a discounted repeat test package for persistent positivity workup. Contact customer service for details.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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