Phospholipid Syndrome Panel Test
Short Name: Phospholipid Syndrome Panel
Also known as: Antiphospholipid Antibody Panel, APS Panel, Lupus Anticoagulant Panel
Phospholipid Syndrome Panel Test test available at DNA Labs India for ₹6,500. Uses EIA (Enzyme Immunoassay), Electromechanical Clot Detection on Serum and Whole Blood samples. Results in The test report is available the next day after the sample reaches the laboratory. Results will be delivered via online portal, email, or WhatsApp as per your preference.. Free home collection in 300+ cities across India.
Overview
The Phospholipid Syndrome Panel Test is used to help diagnose antiphospholipid syndrome (APS) by detecting the presence of antiphospholipid antibodies (anticardiolipin IgG/IgM) and lupus anticoagulant. These antibodies and functional coagulation inhibitor are associated with an increased risk of venous and arterial thrombosis, as well as adverse pregnancy outcomes such as recurrent miscarriage, preeclampsia, and intrauterine growth restriction.
- Test Code
- 3551
- CPT Code
- NA
- ICD Code
- D68.62
- Price
- ₹6,500
- Sample Type
- Serum and Whole Blood
- Result Time
- The test report is available the next day after the sample reaches the laboratory. Results will be delivered via online portal, email, or WhatsApp as per your preference.
- Fasting Required
- Yes (8 hours)
- Method
- EIA (Enzyme Immunoassay), Electromechanical Clot Detection
Sample Collection
Overnight fasting is preferred. It is recommended that the patient discontinues Heparin for 1 day and oral anticoagulants for 7 days prior to sampling, as these drugs may affect test results. Discontinuation should only occur with prior consent from the treating physician. A duly filled Coagulation Requisition Form (Form 15) is mandatory.
Method: Venipuncture
Laboratory Analysis
Standard venipuncture technique will be performed. Blood is collected into an SST tube for serum and a Blue Top (Sodium Citrate) tube for whole blood. Mix the blood in the Blue Top tube thoroughly by gentle inversion to ensure proper anticoagulation.
Report Delivery
Transport the specimen to the laboratory within 4 hours. If immediate transport is not possible, prepare platelet-poor plasma (PPP) within 1 hour of collection: centrifuge the citrated blood at 3600 rpm for 15 minutes, transfer the supernatant to a clean plastic tube, and re-centrifuge again. Then transfer the final PPP to a labeled screw-capped vial. Freeze immediately and ship frozen. Do not thaw.
Timeline: The test report is available the next day after the sample reaches the laboratory. Results will be delivered via online portal, email, or WhatsApp as per your preference.
Patient Instructions
About This Test
Who Should Get This Test
The Phospholipid Syndrome Panel Test is used to help diagnose antiphospholipid syndrome (APS) by detecting the presence of antiphospholipid antibodies (anticardiolipin IgG/IgM) and lupus anticoagulant. These antibodies and functional coagulation inhibitor are associated with an increased risk of venous and arterial thrombosis, as well as adverse pregnancy outcomes such as recurrent miscarriage, preeclampsia, and intrauterine growth restriction.
How to Prepare
- Overnight fasting is preferred.
- Patient must discontinue Heparin for 1 day and oral anticoagulants for 7 days prior to sampling, with physician consent.
- Duly filled Coagulation Requisition Form (Form 15) is mandatory.
- If transport to lab exceeds 4 hours, prepare PPP within 1 hour and freeze immediately.
- Do not thaw frozen samples during transport.
Doctor's Notes
"Early detection of antiphospholipid antibodies is crucial to prevent recurrent thromboembolic events and pregnancy complications. This panel provides a comprehensive assessment of the most relevant antibodies and functional coagulation status."
Test Parameters & Specifications
Sample Stability
- Clotted sample because of improper mixing
- Hemolyzed or lipemic sample may interfere with assays
- Samples not transported within 4 hours or not processed as directed
- Incorrect labeling or missing Coagulation Requisition Form
Understanding Your Results
Positive Anticardiolipin IgG or IgM (medium/high titers)
May indicate antiphospholipid syndrome, especially if persistent and associated with clinical events.
Positive Lupus Anticoagulant (dRVVT)
Indicates a functional inhibitor of phospholipid-dependent coagulation; strongly associated with thrombosis and adverse pregnancy outcomes.
Negative all antibodies and LA
Antiphospholipid syndrome is unlikely; however, transient negativity can occur, and repeat testing may be needed based on clinical suspicion.
Low positive antibodies without clinical events
May be nonspecific; repeat testing after 12 weeks is recommended to confirm persistence.
If you have experienced recurrent blood clots, unexplained miscarriages, stroke at a young age, or other symptoms listed under indications, consult a physician or haematologist for an evaluation. A positive test result should be discussed with your doctor to plan appropriate management, which may include anticoagulation therapy. Never disregard professional medical advice based on a test result alone.
Limitations
- ⚠No single test confirms antiphospholipid syndrome; interpretation requires clinical correlation with other laboratory and imaging findings.
- ⚠Transient positivity may occur in infections, medications, or other autoimmune conditions.
- ⚠Lupus anticoagulant testing can be problematic in patients on anticoagulant therapy or with clotting factor deficiencies.
- ⚠Reference ranges may vary between laboratories; results should be interpreted by a qualified specialist.
Risks & Considerations
- ●Slight pain or bruising at the needle site
- ●Dizziness or lightheadedness during or after blood draw
- ●Rare risk of infection or excessive bleeding
Interfering Factors
- ●Heparin therapy: may interfere with lupus anticoagulant testing; should be discontinued for at least 24 hours before collection if possible.
- ●Oral anticoagulants (e.g., warfarin): may affect coagulation assays; should be discontinued for 7 days prior to sampling with physician approval.
- ●Recent acute thrombosis or anticoagulation may influence antibody levels and coagulation results.
- ●Inadequate sample mixing, incomplete clotting, or delayed transport can lead to false results.
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