Skip to main content
DNA Labs India

APOB Gene Hypercholesterolemia type B autosomanl dominant NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

APOB Gene Hypercholesterolemia type B autosomanl dominant NGS Genetic Test

Short Name: APOB Gene NGS Test

Also known as: Familial hypercholesterolemia type B test, APOB mutation analysis

APOB Gene Hypercholesterolemia type B autosomanl dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next Generation Sequencing (NGS)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the APOB Gene Hypercholesterolemia NGS Genetic Test is to accurately diagnose mutations in the APOB gene that cause autosomal dominant hypercholesterolemia type B. This helps in early identification of at-risk individuals, guiding personalized treatment plans, and facilitating genetic counseling to prevent cardiovascular complications.

Test Code
2081
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required; inform the healthcare provider about any medications or recent medical procedures.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm or a finger-prick for FTA card collection by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the collection site to prevent bleeding; there is no significant downtime, and normal activities can resume immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session recommended to discuss family history and implications of testing. No fasting or special preparation needed.
2
During the Test:A small blood sample is collected via venipuncture or finger-prick. The process takes about 10-15 minutes.
3
After the Test:Results are available in 3-4 weeks. A follow-up consultation with a healthcare provider is advised to discuss findings and next steps.

About This Test

Who Should Get This Test

The purpose of the APOB Gene Hypercholesterolemia NGS Genetic Test is to accurately diagnose mutations in the APOB gene that cause autosomal dominant hypercholesterolemia type B. This helps in early identification of at-risk individuals, guiding personalized treatment plans, and facilitating genetic counseling to prevent cardiovascular complications.

How to Prepare

  • Ensure proper patient identification and sample labeling
  • Use sterile equipment and follow aseptic techniques
  • For FTA card, apply one drop of blood and allow to dry
  • Transport samples at room temperature as specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for APOB mutations is crucial for identifying individuals at high risk of familial hypercholesterolemia, enabling early intervention and lifestyle modifications to prevent cardiovascular complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed samples
  • Improperly labeled or unlabeled specimens
  • Samples in expired collection containers

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the APOB gene. Genetic counseling is recommended for result interpretation and subsequent steps.
📊

Positive for pathogenic variants

Confirms diagnosis of hypercholesterolemia type B; recommend cardiology consultation and genetic counseling for family members.

📊

Negative for pathogenic variants

No mutations detected; however, clinical evaluation for other causes of hypercholesterolemia may be needed if symptoms persist.

📊

Variant of uncertain significance

Further testing and family studies may be required for clarification; follow up with a genetic specialist.

⚠️ When to Consult a Doctor:

Consult a doctor if the test result is positive, if you have symptoms of hypercholesterolemia, or if there is a family history of early heart disease.

Limitations

  • ⚠This test may not detect all possible genetic variants in the APOB gene
  • ⚠Results require clinical correlation with patient history and symptoms
  • ⚠Genetic testing does not replace regular lipid profile monitoring
  • ⚠False negatives or positives are possible but rare with NGS technology

Risks & Considerations

  • ●Minimal risk from blood draw, such as slight pain, bruising, or infection at the collection site
  • ●Psychological impact from genetic results; genetic counseling provided

Interfering Factors

  • ●Contaminated or improperly stored samples may yield inaccurate results
  • ●Hemolyzed blood samples can affect DNA quality
  • ●Recent blood transfusions may interfere with genetic analysis

Compare With Similar Tests

TestAPOB Gene Hypercholesterolemia type B autosomanl dominant NGS Genetic TestLipid Profile TestPCSK9 Gene TestFamilial Hypercholesterolemia PanelLDL Receptor Gene Test
ComparisonAPOB Gene Hypercholesterolemia type B autosomanl dominant NGS Genetic Test

Frequently Asked Questions

What is the APOB Gene Hypercholesterolemia NGS Genetic Test?
It is a genetic test that uses Next Generation Sequencing to detect mutations in the APOB gene, which cause autosomal dominant hypercholesterolemia type B, a condition with high cholesterol levels.
Who should consider this test?
Individuals with a family history of hypercholesterolemia, early-onset heart disease, persistently high cholesterol, or those seeking genetic counseling for familial disorders.
How is the test performed?
A blood sample or DNA is collected and analyzed using NGS technology to identify mutations in the APOB gene.
What does a positive result mean?
A positive result confirms the presence of pathogenic mutations, indicating a diagnosis of hypercholesterolemia type B, and guides further medical management.
Is fasting required for this test?
No, fasting is not required. The test involves genetic analysis of blood or DNA samples.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What are the risks of this test?
Risks are minimal, primarily related to blood draw, such as bruising or infection, and potential psychological impact from results.
Can this test be used for prenatal diagnosis?
It is primarily for diagnostic purposes in individuals; prenatal testing may require additional genetic counseling and specialized tests.
How accurate is the NGS Genetic Test?
NGS technology is highly accurate for detecting mutations, but no test is 100% infallible; clinical correlation is recommended.
What should I do if my result is positive?
Consult a cardiologist or geneticist for personalized treatment plans and consider genetic testing for family members.
Is this test covered by insurance?
Coverage varies by insurance provider; it is not typically covered under government schemes like PMJAY, but private insurance may offer partial coverage.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

KCNA5 Gene Atrial fibrillation type 7 NGS Genetic Test

₹20,000

EPHX2 Gene Hypercholesterolemia, familial, due to LDLR defect, modifier of NGS Genetic Test

₹20,000

MICM (Maternally Inherited Cardiomyopathy) Mutation Detection Test

₹10,500

DSC2 Gene Arrhythmogenic right ventricular cardiomyopathy type 11 NGS Genetic Test

₹20,000

MYH6 Gene Atrial septal defect type 3 NGS Genetic Test

₹20,000

MAP2K2 Gene Cardiofaciocutaneous syndrome type 4 NGS Genetic Test

₹20,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.