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MICM (Maternally Inherited Cardiomyopathy) Mutation Detection Test

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MICM (Maternally Inherited Cardiomyopathy) Mutation Detection Test

Short Name: MICM Mutation Detection Test

Also known as: Maternally Inherited Cardiomyopathy Test, Mitochondrial Cardiomyopathy Mutation Test, mtDNA Cardiomyopathy Screening, Mitochondrial DNA Cardiomyopathy Panel

MICM (Maternally Inherited Cardiomyopathy) Mutation Detection Test test available at DNA Labs India for ₹10,500. Uses Polymerase Chain Reaction (PCR), Mitochondrial DNA Sequencing on Whole Blood samples. Results in Reports are typically available within 10 working days from sample receipt at the laboratory. Reports are delivered via the online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.

Molecular / GeneticAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

This assay detects pathogenic mutations in mitochondrial DNA (mtDNA) which are responsible for the maternal inheritance pattern observed in certain cardiomyopathies. It is intended for diagnostic confirmation in symptomatic individuals, predictive testing in at-risk family members, and carrier assessment for reproductive planning.

Test Code
1242
CPT Code
81404
ICD Code
I42.8
Price
₹10,500
Sample Type
Whole Blood
Result Time
Reports are typically available within 10 working days from sample receipt at the laboratory. Reports are delivered via the online portal, email, or WhatsApp.
Fasting Required
No
Method
Polymerase Chain Reaction (PCR), Mitochondrial DNA Sequencing
Step 1

Sample Collection

Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly completed. No fasting is required. Inform the laboratory of any recent blood transfusions within the past 4 weeks, as this may affect test results.

Method: Venipuncture

Step 2

Laboratory Analysis

A trained phlebotomist will collect approximately 4 mL of venous blood into a lavender top (EDTA) tube using standard venipuncture technique. The procedure typically takes less than 5 minutes.

Step 3

Report Delivery

Apply pressure to the puncture site with sterile gauze for 2–3 minutes. The blood sample will be shipped refrigerated to the laboratory. Do not freeze the sample. Mild bruising at the site may occur and resolves spontaneously.

Timeline: Reports are typically available within 10 working days from sample receipt at the laboratory. Reports are delivered via the online portal, email, or WhatsApp.

Patient Instructions

1
Before the Test:No special preparation or fasting is required. Complete the mandatory Genomics Clinical Information Requisition Form (Form 20) with details of family history and clinical symptoms. Bring a valid photo ID and any prior cardiac investigation reports.
2
During the Test:A blood sample of approximately 4 mL will be drawn from a vein in your arm using a needle and collected into an EDTA (lavender top) tube. The procedure is quick, minimally invasive, and typically completed within 5 minutes.
3
After the Test:After blood collection, apply gentle pressure on the puncture site. You may resume normal activities immediately. The sample will be transported under refrigerated conditions to the DNA Labs India laboratory for molecular analysis.

About This Test

Who Should Get This Test

This assay detects pathogenic mutations in mitochondrial DNA (mtDNA) which are responsible for the maternal inheritance pattern observed in certain cardiomyopathies. It is intended for diagnostic confirmation in symptomatic individuals, predictive testing in at-risk family members, and carrier assessment for reproductive planning.

How to Prepare

  • Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
  • Collect 4 mL (2 mL minimum) whole blood in 1 Lavender top (EDTA) tube
  • Ship the sample refrigerated — DO NOT FREEZE
  • Label the tube clearly with patient name, date of birth, and sample collection date
  • Avoid hemolysis by gently inverting the tube 8–10 times after collection
  • Inform the lab of any recent blood transfusion or bone marrow transplant

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Mitochondrial DNA mutations are exclusively maternally inherited. Any individual with a family history of cardiomyopathy on the mother's side should consider MICM genetic screening, especially during preconception counseling or when presenting with unexplained cardiac symptoms. Early identification of pathogenic mtDNA variants allows for proactive cardiac surveillance in at-risk family members across multiple generations."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood
Sample Volume4 mL (2 mL minimum)
ContainerLavender top (EDTA) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature
Refrigerated (2–8°C)
Frozen
Sample Rejection Criteria:
  • Sample received frozen
  • Sample collected in incorrect tube type (non-EDTA)
  • Insufficient sample volume (less than 2 mL)
  • Missing or incomplete Genomics Clinical Information Requisition Form (Form 20)
  • Sample received at room temperature beyond acceptable transit time
  • Heavily hemolyzed or clotted sample

Understanding Your Results

The MICM Mutation Detection Test report indicates whether pathogenic mitochondrial DNA mutations associated with maternally inherited cardiomyopathy were detected. Results should be interpreted by a qualified geneticist or cardiologist in the context of the patient's clinical presentation, family history, and other diagnostic findings.
📊

Negative — No pathogenic mtDNA variants detected

No known mutations associated with maternally inherited cardiomyopathy were identified in the mitochondrial DNA. This significantly reduces the likelihood of MICM but does not exclude all genetic causes of cardiomyopathy. Clinical correlation and further evaluation may be warranted if symptoms persist.

📊

Positive — Pathogenic mtDNA variant detected

A mutation in mitochondrial DNA associated with maternally inherited cardiomyopathy has been identified. Genetic counseling is recommended. Family members may benefit from predictive testing. Cardiac surveillance and management should be coordinated with a cardiologist.

📊

Variant of Uncertain Significance (VUS)

A mitochondrial DNA variant was detected whose clinical significance cannot be definitively determined with current evidence. Correlation with clinical findings and family segregation studies is recommended. Periodic reclassification of the variant should be pursued as new data become available.

⚠️ When to Consult a Doctor:

Consult a cardiologist or genetic specialist if you experience persistent shortness of breath, chest pain, unexplained fatigue, dizziness, or swelling in the legs — particularly if there is a maternal family history of heart disease or cardiomyopathy. If test results are positive, seek genetic counseling to discuss implications for family members and reproductive planning.

Limitations

  • ⚠This test does not screen for nuclear DNA mutations that may also cause cardiomyopathy
  • ⚠Novel or previously unreported mtDNA variants may not be included in the mutation panel
  • ⚠Heteroplasmy levels can vary across tissues; blood-based testing may not fully reflect mutation burden in cardiac tissue
  • ⚠A negative result does not completely exclude a genetic basis for cardiomyopathy as other genetic or non-genetic causes may exist
  • ⚠Clinical significance of certain detected variants may remain uncertain (variants of uncertain significance)

Risks & Considerations

  • ●Minimal risk associated with blood draw — minor bruising or soreness at the puncture site
  • ●Possible psychological impact of genetic test results — genetic counseling is recommended
  • ●Risk of incidental findings — variants of uncertain significance may cause anxiety

Interfering Factors

  • ●Recent blood transfusion may affect mitochondrial DNA analysis due to donor DNA contamination
  • ●Heteroplasmy levels below the detection threshold of the assay may yield false-negative results
  • ●Sample hemolysis or improper storage may compromise DNA quality and test accuracy
  • ●Concurrent use of certain chemotherapeutic agents may alter mitochondrial DNA integrity

Compare With Similar Tests

TestMICM (Maternally Inherited Cardiomyopathy) Mutation Detection TestComprehensive Cardiomyopathy Gene PanelEchocardiogramCardiac MRIWhole Exome Sequencing (WES)
ComparisonMICM (Maternally Inherited Cardiomyopathy) Mutation Detection TestThe comprehensive panel screens multiple nuclear and mitochondrial genes, while the MICM test focuses exclusively on mitochondrial DNA mutations with maternal inheritance.An echocardiogram provides structural and functional imaging of the heart, while the MICM test identifies the underlying genetic mutation. Both are complementary for diagnosis.Cardiac MRI offers detailed imaging of myocardial tissue, useful for assessing cardiomyopathy severity, whereas the MICM test identifies the genetic etiology.WES analyzes all protein-coding genes including nuclear DNA, but may have limited mitochondrial DNA coverage. The MICM test offers targeted, higher-sensitivity analysis of mtDNA.

Frequently Asked Questions

What is the MICM Mutation Detection Test?
The MICM Mutation Detection Test is a genetic test that analyzes mitochondrial DNA (mtDNA) to identify mutations responsible for Maternally Inherited Cardiomyopathy — a heart muscle disorder passed from mother to child through mitochondrial genes.
Who should consider taking the MICM Mutation Detection Test?
Individuals with a maternal family history of cardiomyopathy, those experiencing unexplained cardiac symptoms (shortness of breath, chest pain, fatigue, dizziness, or leg swelling), and people seeking preconception genetic risk assessment should consider this test.
How is the MICM test different from a standard cardiomyopathy gene panel?
The MICM test specifically targets mitochondrial DNA mutations responsible for maternal inheritance patterns, while standard cardiomyopathy panels typically focus on nuclear DNA genes. Both may be complementary depending on the clinical scenario.
What sample is required for the MICM Mutation Detection Test?
The test requires 4 mL (2 mL minimum) of whole blood collected in a lavender top (EDTA) tube. The sample is shipped refrigerated and must not be frozen.
Is fasting required before the MICM test?
No, fasting is not required. However, the Genomics Clinical Information Requisition Form (Form 20) must be duly completed before sample collection.
How much does the MICM Mutation Detection Test cost in India?
The MICM Mutation Detection Test costs INR 10500 at DNA Labs India. This price includes free home sample collection across India in most major cities.
How long does it take to get the MICM test results?
Reports are typically available within 10 working days from the date the sample reaches the laboratory. Reports are delivered via the online portal, email, or WhatsApp.
What does a positive MICM test result mean?
A positive result means a pathogenic mitochondrial DNA mutation associated with maternally inherited cardiomyopathy has been detected. This warrants genetic counseling, cardiac evaluation by a cardiologist, and possible screening of at-risk family members.
Can a negative MICM test rule out cardiomyopathy?
No. A negative result means no known mtDNA mutations associated with MICM were found, but it does not exclude cardiomyopathy caused by nuclear DNA mutations or other non-genetic factors. Further evaluation may be needed based on symptoms and clinical findings.
Is the MICM Mutation Detection Test available across India?
Yes. DNA Labs India offers free home sample collection for the MICM test in numerous cities across India, including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, Pune, Ahmedabad, and many more. Online booking is available.
Why is MICM called a maternally inherited condition?
Mitochondria — and their DNA — are inherited exclusively from the mother. Therefore, mutations in mitochondrial DNA are passed from mother to all her children. Fathers do not transmit mitochondrial DNA, which is why the condition follows maternal inheritance.
Is genetic counseling recommended before and after the MICM test?
Yes. Genetic counseling before the test helps ensure informed consent and understanding of implications. Post-test counseling is recommended, especially for positive results, to discuss management options, family screening, and reproductive planning.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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