Skip to main content
DNA Labs India

NOTCH1 Gene Aortic valve disease type 1 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NOTCH1 Gene Aortic valve disease type 1 NGS Genetic Test

Short Name: NOTCH1 Aortic Valve Disease NGS Test

Also known as: NOTCH1 Mutation Analysis, Hereditary Aortic Valve Disease Genetic Test

NOTCH1 Gene Aortic valve disease type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify pathogenic mutations in the NOTCH1 gene for the diagnosis and management of aortic valve disease type 1.

Test Code
2556
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling session.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample will be collected via venipuncture or FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review.
2
During the Test:Sample collection and processing in the lab using NGS technology.
3
After the Test:Report generation and genetic counseling for result interpretation.

About This Test

Who Should Get This Test

To identify pathogenic mutations in the NOTCH1 gene for the diagnosis and management of aortic valve disease type 1.

How to Prepare

  • Follow any specific instructions from the lab
  • Bring identification and prescription
  • Inform about any medications or health conditions

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This genetic test is crucial for identifying hereditary risks of aortic valve disease, enabling early intervention and family screening."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect container

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the NOTCH1 gene, guiding clinical decisions.
📊

Positive for pathogenic variant

Indicates genetic predisposition to aortic valve disease type 1. Consult a geneticist for management and family screening.

📊

Negative

No pathogenic variants detected. Clinical correlation recommended if symptoms persist.

📊

Variant of uncertain significance

Further testing and family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

If you have a family history of aortic valve disease or experience symptoms like chest pain or shortness of breath, consult a cardiologist or geneticist promptly.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal physical risk from blood draw
  • ●Psychological impact of genetic results
  • ●Potential for anxiety or stress

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Technical errors in sequencing

Frequently Asked Questions

What is the NOTCH1 Gene Aortic Valve Disease Type 1 NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the NOTCH1 gene associated with hereditary aortic valve disease.
Who should consider getting this test?
Individuals with a family history of aortic valve disease, those with symptoms like chest pain or shortness of breath, or for predictive testing in at-risk families.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to identify mutations in the NOTCH1 gene.
What is the cost of the test in India?
The cost is INR 20,000, which includes home sample collection and genetic analysis.
How long does it take to get the results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
What are the symptoms of aortic valve disease type 1?
Symptoms may include chest pain, shortness of breath, fatigue, dizziness, and rapid or irregular heartbeat.
How accurate is the NGS genetic test?
NGS technology provides high accuracy in detecting genetic mutations, but results should be interpreted by a genetic counselor.
What does a positive test result mean?
A positive result indicates a pathogenic mutation in the NOTCH1 gene, increasing the risk for aortic valve disease. Consult a healthcare provider for management.
Can this test be used for family screening?
Yes, it can identify at-risk family members through predictive testing.
Are there any risks associated with the test?
The test involves minimal physical risk from blood draw, but there may be psychological implications. Genetic counseling is recommended.
How do I prepare for the test?
Provide your clinical history, undergo genetic counseling, and follow any specific instructions from the lab.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

APOB Gene Hypercholesterolemia type B autosomanl dominant NGS Genetic Test

₹20,000

MICM (Maternally Inherited Cardiomyopathy) Mutation Detection Test

₹10,500

EPHX2 Gene Hypercholesterolemia, familial, due to LDLR defect, modifier of NGS Genetic Test

₹20,000

DSC2 Gene Arrhythmogenic right ventricular cardiomyopathy type 11 NGS Genetic Test

₹20,000

KCNA5 Gene Atrial fibrillation type 7 NGS Genetic Test

₹20,000

MYH6 Gene Atrial septal defect type 3 NGS Genetic Test

₹20,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.