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MYH6 Gene Atrial septal defect type 3 NGS Genetic Test

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MYH6 Gene Atrial septal defect type 3 NGS Genetic Test

Short Name: MYH6 ASD Type 3 NGS Test

Also known as: MYH6 Gene Test for ASD Type 3, Atrial Septal Defect Genetic Test, MYH6 NGS Sequencing

MYH6 Gene Atrial septal defect type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the MYH6 Gene Atrial Septal Defect Type 3 NGS Genetic Test is to identify mutations or variants in the MYH6 gene associated with an increased risk of developing atrial septal defect type 3. This test aids in confirming genetic etiology, assessing hereditary patterns, supporting clinical diagnosis, and guiding personalized management strategies for patients and families affected by congenital heart defects.

Test Code
2505
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation is required. Ensure genetic counseling is completed and clinical history is provided.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm using standard venipuncture techniques. For FTA card collection, a single drop of blood is applied.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless otherwise advised.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Complete genetic counseling and provide detailed clinical and family history. No fasting is required.
2
During the Test:A blood sample is collected via venipuncture or using an FTA card. The process is quick and minimally invasive.
3
After the Test:Resume normal activities. Results will be available in 3 to 4 weeks via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of the MYH6 Gene Atrial Septal Defect Type 3 NGS Genetic Test is to identify mutations or variants in the MYH6 gene associated with an increased risk of developing atrial septal defect type 3. This test aids in confirming genetic etiology, assessing hereditary patterns, supporting clinical diagnosis, and guiding personalized management strategies for patients and families affected by congenital heart defects.

How to Prepare

  • Provide accurate clinical and family history information
  • Ensure sample is labeled correctly with patient details
  • Use sterile collection tubes or FTA cards as specified
  • Transport sample to the laboratory within the recommended stability period

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for MYH6 mutations is crucial for early diagnosis and management of atrial septal defects, especially in families with a history of congenital heart disease."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5-10 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood in EDTA tube: Stable for 7 days at 2-8°C
Extracted DNA: Stable for 1 year at -20°C
FTA card: Stable for several years at room temperature
Sample Rejection Criteria:
  • Sample hemolyzed, clotted, or insufficient volume
  • Incorrect sample type or container used
  • Missing patient identification or consent forms
  • Sample exceeded stability period

Understanding Your Results

Results from the MYH6 Gene Atrial Septal Defect Type 3 NGS Genetic Test should be interpreted by a qualified geneticist or healthcare provider. Positive findings indicate the presence of pathogenic variants linked to ASD type 3, while negative results suggest no detectable mutations in the analyzed regions.
📊

Pathogenic or likely pathogenic variant detected in the MYH6 gene, associated with increased risk of atrial septal defect type 3. Genetic counseling and clinical follow-up are recommended.

Result type: Positive

📊

No pathogenic variants detected in the MYH6 gene. However, this does not exclude other genetic causes or environmental factors contributing to ASD.

Result type: Negative

📊

A genetic variant was identified but its clinical significance is unknown. Further testing and family studies may be required for clarification.

Result type: Variant of Uncertain Significance (VUS)

⚠️ When to Consult a Doctor:

Consult a doctor if you have a family history of congenital heart defects, experience symptoms of atrial septal defect, or receive positive or uncertain genetic test results. Early consultation can facilitate appropriate management and genetic counseling.

Limitations

  • ⚠This test may not detect all genetic variants or mutations in the MYH6 gene
  • ⚠Results may include variants of uncertain significance (VUS) requiring further evaluation
  • ⚠Does not rule out other genetic or environmental causes of atrial septal defect
  • ⚠Interpretation requires correlation with clinical findings and family history

Risks & Considerations

  • ●Minimal risk from blood draw, such as slight pain, bruising, or infection at the puncture site
  • ●Psychological impact of genetic results, requiring appropriate counseling

Interfering Factors

  • ●Poor sample quality or insufficient DNA quantity
  • ●Contamination during sample collection or processing
  • ●Recent blood transfusions may affect DNA analysis
  • ●Technical limitations in detecting all variant types

Compare With Similar Tests

TestMYH6 Gene Atrial septal defect type 3 NGS Genetic TestEchocardiogramCardiac MRIGenetic Counseling SessionOther NGS Panels for Cardiac Genetics
ComparisonMYH6 Gene Atrial septal defect type 3 NGS Genetic TestImaging test to visualize heart structure; detects ASD but does not identify genetic causes.Detailed imaging for heart defects; complementary to genetic testing for comprehensive assessment.Provides risk assessment and guidance based on family history; often paired with genetic testing.Broader genetic panels may include multiple genes associated with congenital heart disease.

Frequently Asked Questions

What is the MYH6 Gene Atrial Septal Defect Type 3 NGS Genetic Test?
This test uses next-generation sequencing to analyze the MYH6 gene for mutations associated with atrial septal defect type 3, a congenital heart condition.
How much does the test cost?
The test costs INR 20,000, with free home sample collection available across India.
What sample type is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
What are the symptoms of atrial septal defect type 3?
Symptoms may include shortness of breath, fatigue, heart palpitations, cyanosis, and frequent respiratory infections, though some individuals are asymptomatic.
How is the genetic test performed?
The test involves analyzing DNA from a blood sample using NGS technology to detect mutations in the MYH6 gene.
What do the test results mean?
Positive results indicate pathogenic variants linked to ASD type 3, while negative results suggest no detectable mutations. Variants of uncertain significance may require further evaluation.
Is the test covered by insurance?
Coverage varies by insurance plan; it is not typically covered under government schemes like PMJAY or CGHS. Check with your provider for details.
Who should consider taking this test?
Individuals with a family history of congenital heart defects, diagnosed ASD type 3, or symptoms suggestive of the condition should consider testing.
Are there any risks associated with the test?
Risks are minimal and include slight discomfort from blood draw. Psychological impacts may occur, so genetic counseling is recommended.
How can I book the test?
You can book the test online through DNA Labs India's website or contact them via phone or WhatsApp for assistance.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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