C-Peptide Response to Glucose 5 Hours Test
Short Name: C-Peptide 5Hr Test
Also known as: C-Peptide Stimulation Test, Glucose Stimulated C-Peptide Test, 5-Hour C-Peptide Response Test, C-Peptide Glucose Challenge Test
C-Peptide Response to Glucose 5 Hours Test test available at DNA Labs India for ₹14,000. Uses Chemiluminescent Immunoassay, Hexokinase on Plasma and Serum samples. Results in Reports are typically available same day via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The purpose of this test is to evaluate insulin production and diagnose diabetes-related conditions. It helps in determining the type of diabetes, monitoring beta-cell function, and identifying other disorders like insulinoma that affect insulin secretion.
- Test Code
- 364
- Price
- ₹14,000
- Sample Type
- Plasma and Serum
- Result Time
- Reports are typically available same day via online portal, email, or WhatsApp.
- Fasting Required
- Yes (12 hours)
- Method
- Chemiluminescent Immunoassay, Hexokinase
Sample Collection
Overnight fasting for 8-12 hours is mandatory. Avoid eating or drinking anything except water. Inform the lab about any medications you are currently taking.
Method: Venipuncture
Laboratory Analysis
A baseline blood sample is drawn, followed by oral administration of glucose solution. Additional samples are taken at specified intervals up to 5 hours.
Report Delivery
Apply pressure to the puncture site to prevent bruising. Resume normal activities and eat a light meal after the test unless otherwise directed by your physician.
Timeline: Reports are typically available same day via online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to evaluate insulin production and diagnose diabetes-related conditions. It helps in determining the type of diabetes, monitoring beta-cell function, and identifying other disorders like insulinoma that affect insulin secretion.
How to Prepare
- Fast overnight for 8-12 hours before the test
- Draw baseline fasting specimen
- Administer glucose solution as directed
- Draw specimens at 0.5, 1, 1.5, 2, 2.5, 3, 4, and 5 hours
- Label each container with time and test required
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"This test is crucial for assessing insulin production and diagnosing diabetes types. Consult an endocrinologist for interpretation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Incorrectly labeled specimens
- Sample received beyond stability period
- Insufficient sample volume
- Non-fasting specimen for fasting parameter
Understanding Your Results
Low C-peptide levels
Suggests reduced insulin production, possibly type 1 diabetes or late-stage type 2 diabetes
High C-peptide levels
Indicates increased insulin production, possibly type 2 diabetes, insulinoma, or Cushing's syndrome
Normal response
Normal insulin production and glucose metabolism with adequate beta-cell function
Delayed peak response
May indicate impaired early-phase insulin secretion, commonly seen in early type 2 diabetes
If you experience symptoms like frequent urination, increased thirst, or unexplained weight loss, or if test results are abnormal, consult an endocrinologist or physician for further evaluation.
Limitations
- ⚠C-peptide levels may not correlate directly with insulin levels in patients with renal impairment
- ⚠Results may be affected by the presence of anti-insulin antibodies
- ⚠This test alone may not be sufficient for definitive diagnosis and should be correlated clinically
- ⚠Not suitable for patients with known glucose intolerance who cannot tolerate glucose load
Risks & Considerations
- ●Minor bruising at puncture site
- ●Rare chance of infection
- ●Temporary dizziness after blood draw
- ●Mild nausea from glucose solution
- ●Lightheadedness during prolonged fasting
Interfering Factors
- ●Recent insulin therapy may alter C-peptide levels
- ●Kidney disease can affect C-peptide clearance
- ●Medications such as sulfonylureas may influence results
- ●Liver disease may impact C-peptide metabolism
- ●Recent meals if fasting protocol not followed
Frequently Asked Questions
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