C1 Esterase Inhibitor Functional (C1 Inactivator Functional) Test
Short Name: C1 Esterase Inhibitor Functional Test
Also known as: C1 Inactivator Functional Test, C1 Inhibitor Functional Assay
C1 Esterase Inhibitor Functional (C1 Inactivator Functional) Test test available at DNA Labs India for ₹9,000. Uses Enzyme Immunoassay on Serum samples. Results in Reports available after 2-3 weeks via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
To diagnose Hereditary Angioedema by evaluating the functional activity of C1 esterase inhibitor protein, which is essential for regulating complement system and preventing swelling episodes.
- Test Code
- 230
- Price
- ₹9,000
- Sample Type
- Serum
- Result Time
- Reports available after 2-3 weeks via online portal, email, or WhatsApp.
- Fasting Required
- No
- Method
- Enzyme Immunoassay
Sample Collection
No special preparation required. Ensure the Test Send Out Consent Form (Form 35) is duly filled.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm using a needle and collected into a red top tube without additives.
Report Delivery
Apply pressure to the puncture site to stop bleeding. Serum must be separated within 1 hour of collection and frozen immediately. Ship frozen without thawing.
Timeline: Reports available after 2-3 weeks via online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
To diagnose Hereditary Angioedema by evaluating the functional activity of C1 esterase inhibitor protein, which is essential for regulating complement system and preventing swelling episodes.
How to Prepare
- Use 1 Red Top (No Additive) tube for sample collection
- Collect 2 mL of blood (0.5 mL minimum)
- Separate serum from cells within 1 hour of collection
- Freeze the serum immediately and ship frozen
- Do not use SST gel barrier tubes
- Submit a duly filled Test Send Out Consent Form (Form 35)
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This test is essential for confirming Hereditary Angioedema, guiding treatment, and preventing life-threatening attacks through early diagnosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not frozen or thawed during transport
- Use of incorrect tube (e.g., SST gel barrier tubes)
- Insufficient sample volume (< 0.5 mL)
- Missing or incomplete Test Send Out Consent Form
- Hemolyzed or lipemic samples
Understanding Your Results
Normal C1-INH Functional Activity
Unlikely to have Hereditary Angioedema; consider other causes of swelling.
Low C1-INH Functional Activity
Consistent with Hereditary Angioedema; further testing may be needed for confirmation.
Borderline Results
Repeat testing recommended during asymptomatic periods; consult immunologist.
Consult an immunologist or allergist if you experience recurrent swelling, have a family history of HAE, or if test results are abnormal.
Limitations
- ⚠May not detect all subtypes of Hereditary Angioedema
- ⚠Requires sample to be frozen and shipped properly; thawing invalidates results
- ⚠Results should be interpreted alongside clinical symptoms and family history
- ⚠Not suitable for real-time monitoring during acute attacks
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site
- ●Rare risk of infection or dizziness
- ●Minimal risk of hematoma
Interfering Factors
- ●Acute angioedema attacks may affect results
- ●Certain medications like ACE inhibitors or estrogens
- ●Improper sample handling or hemolysis
- ●Recent blood transfusions or immunoglobulin therapy
Frequently Asked Questions
What is the C1 Esterase Inhibitor Functional Test?
Why is this test recommended?
How is the test performed?
Is fasting required before the test?
What is the cost of the test?
How long does it take to get results?
Can this test detect all types of Hereditary Angioedema?
What should I do if my results are abnormal?
Is home sample collection available for this test?
Are there any risks associated with the test?
How should the sample be handled?
What is the difference between C1 Esterase Inhibitor Functional and C1 Inactivator Functional tests?
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