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CALCRL Gene Vascular system defects due to CALCRL deficiency NGS Genetic Test

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CALCRL Gene Vascular system defects due to CALCRL deficiency NGS Genetic Test

Short Name: CALCRL Gene NGS Test

Also known as: CALCRL deficiency genetic test, Vascular defect NGS test, CALCRL mutation screening

CALCRL Gene Vascular system defects due to CALCRL deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the CALCRL Gene NGS Genetic Test is to identify mutations or deficiencies in the CALCRL gene that may cause vascular system defects. This helps in diagnosing conditions related to blood pressure regulation and cardiovascular health, enabling personalized treatment plans.

Test Code
5353
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and family pedigree chart. Genetic counseling session recommended.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or finger-prick.

Step 3

Report Delivery

Apply pressure to the puncture site. Sample sent to lab for analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment.
2
During the Test:Blood sample collection and DNA extraction.
3
After the Test:Sample analysis and report generation.

About This Test

Who Should Get This Test

The purpose of the CALCRL Gene NGS Genetic Test is to identify mutations or deficiencies in the CALCRL gene that may cause vascular system defects. This helps in diagnosing conditions related to blood pressure regulation and cardiovascular health, enabling personalized treatment plans.

How to Prepare

  • Fast for 8-12 hours if required, but not specified for this test
  • Avoid strenuous activity before sample collection
  • Inform about any medications

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for CALCRL mutations can help in timely management of vascular disorders and prevent complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed or insufficient sample
  • Incorrect sample type
  • Missing patient information

Understanding Your Results

Results indicate the presence or absence of mutations in the CALCRL gene. Positive results may suggest a genetic predisposition to vascular defects.
📊

No mutations detected

Normal; low risk for CALCRL-related vascular defects

📊

Pathogenic variant detected

Increased risk for vascular system defects; consult genetic counselor

⚠️ When to Consult a Doctor:

If you have a family history of vascular diseases or experience symptoms like persistent dizziness, chest pain, or blood pressure abnormalities.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during sample handling
  • ●Technical errors in sequencing

Frequently Asked Questions

What is the CALCRL gene?
The CALCRL gene codes for a protein involved in regulating blood pressure and maintaining the vascular system. Mutations can lead to vascular defects.
What are vascular system defects due to CALCRL deficiency?
These include hypertension, hypotension, vasodilation, vasoconstriction, and cardiovascular diseases caused by mutations in the CALCRL gene.
How is the CALCRL Gene NGS Test performed?
The test uses Next-Generation Sequencing (NGS) to sequence the entire coding region of the CALCRL gene from a blood or DNA sample.
What is the cost of the test?
The cost at DNA Labs India is INR 20,000, with free home sample collection available across India.
What sample is required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in many cities across India.
What are the symptoms of CALCRL deficiency?
Symptoms may include dizziness, fainting, chest pain, shortness of breath, headaches, blurred vision, nausea, and fatigue.
How is CALCRL deficiency diagnosed?
Diagnosis involves clinical evaluation, blood pressure monitoring, ECG, echocardiogram, and genetic testing like the NGS Genetic Test.
What should I do if I test positive for a CALCRL mutation?
Consult a healthcare professional or genetic counselor for further evaluation and management of vascular defects.
Is genetic counseling necessary before the test?
Yes, a genetic counseling session is recommended to draw a family pedigree chart and understand the implications of testing.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, but genetic results may have psychological impacts.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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