DNA Viral Metagenome Sequencing and Analysis Test
Short Name: Viral Metagenomics
Also known as: Viral Metagenomics, Shotgun Metagenomic Sequencing for Viruses, Unbiased Viral Sequencing
DNA Viral Metagenome Sequencing and Analysis Test test available at DNA Labs India for ₹30,000. Uses Next-Generation Sequencing (NGS), Metagenomic Analysis on Extracted DNA samples. Results in Results are typically available within 8 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of DNA viral metagenome sequencing is to identify the causative viral agent in patients with suspected viral infections, especially when conventional diagnostic tests have failed to yield a definitive result. It is also used for epidemiological surveillance, outbreak investigations, and discovery of novel viruses. By providing a comprehensive viral profile, this test assists clinicians in making accurate diagnoses, guiding antiviral therapy, and implementing appropriate infection control measures.
- Test Code
- 6338
- CPT Code
- N/A
- ICD Code
- N/A
- Price
- ₹30,000
- Sample Type
- Extracted DNA
- Result Time
- Results are typically available within 8 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Metagenomic Analysis
Sample Collection
No special preparation is required. However, inform your doctor about any medications you are taking, especially antiviral drugs, as they may affect the test results.
Method: Blood draw or as per specimen type
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist. For other sample types (e.g., CSF, tissue), the collection will be performed by a healthcare professional as per standard protocols.
Report Delivery
You can resume normal activities immediately after sample collection. No specific aftercare is required.
Timeline: Results are typically available within 8 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of DNA viral metagenome sequencing is to identify the causative viral agent in patients with suspected viral infections, especially when conventional diagnostic tests have failed to yield a definitive result. It is also used for epidemiological surveillance, outbreak investigations, and discovery of novel viruses. By providing a comprehensive viral profile, this test assists clinicians in making accurate diagnoses, guiding antiviral therapy, and implementing appropriate infection control measures.
How to Prepare
- Ensure the sample is collected in a sterile container provided by the lab.
- For home collection, the phlebotomist will follow all safety protocols.
- Label the sample with patient details and collection time.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Viral metagenomic sequencing is a powerful tool for identifying elusive viral pathogens, especially in immunocompromised patients or when conventional tests are negative. It provides a comprehensive view of the viral landscape, enabling targeted therapy and better patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient quantity of extracted DNA
- Improperly labeled or misidentified samples
- Samples not stored at appropriate temperature
Understanding Your Results
No viral pathogen was identified in the sample. This may indicate a non-viral etiology or a viral infection with a viral load below the detection limit.
The presence of a specific virus suggests a likely causative role, especially if the virus is known to be pathogenic and correlates with clinical symptoms.
Co-infection with multiple viruses is possible, especially in immunocompromised patients. The clinical significance of each virus should be evaluated.
Detection of a novel virus requires further investigation and may represent a newly emerging pathogen. Consultation with an infectious disease specialist is recommended.
Consult your doctor if you experience persistent or worsening symptoms of a viral infection, such as high fever, difficulty breathing, confusion, or severe dehydration. Early diagnosis and treatment are crucial for better outcomes.
Limitations
- ⚠May not detect RNA viruses unless reverse transcription is performed (this test is DNA-based)
- ⚠Requires high-quality extracted DNA
- ⚠Bioinformatics analysis may not identify very divergent or novel viruses
- ⚠Clinical correlation is essential; detection of virus does not always imply causation
- ⚠Not a routine screening test; reserved for complex cases
Risks & Considerations
- ●Minimal risk of bleeding or infection at the blood draw site
- ●No significant risks associated with the test itself
Interfering Factors
- ●Sample contamination with non-viral DNA
- ●Low viral load in the sample
- ●Degraded DNA due to improper storage or transport
- ●Recent antiviral therapy may reduce viral load
- ●Host DNA dominance may reduce sensitivity
Compare With Similar Tests
| Test | DNA Viral Metagenome Sequencing and Analysis | PCR (Polymerase Chain Reaction) | Viral Culture | Serology (Antibody/Antigen) |
|---|---|---|---|---|
| Comparison | DNA Viral Metagenome Sequencing and Analysis | PCR is targeted and detects specific known viruses with high sensitivity. Metagenomic sequencing is unbiased and can detect any virus, including novel ones, but is more expensive and time-consuming. | Viral culture requires live virus and takes longer. Metagenomic sequencing is faster and can detect non-cultivable viruses. | Serology detects immune response or viral antigens, but may have false negatives early in infection. Metagenomic sequencing directly detects viral genetic material. |
Frequently Asked Questions
What is DNA viral metagenome sequencing?
How is this test different from a standard viral PCR?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get results?
Can this test detect RNA viruses?
Is home sample collection available?
What is the cost of the test?
Will this test detect all viral infections?
Is the test covered by insurance?
What should I do if the test detects a virus?
Are there any risks associated with the test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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