DST Gene Neuropathy, hereditary sensory and autonomic type 6 NGS Genetic Test
Short Name: DST HSAN6 NGS Test
Also known as: HSAN6 Genetic Test, DST Gene Mutation Analysis, Hereditary Sensory and Autonomic Neuropathy Type 6 NGS Test
DST Gene Neuropathy, hereditary sensory and autonomic type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally delivered within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The test is intended to identify disease-causing variants in the DST gene to establish a molecular diagnosis of hereditary sensory and autonomic neuropathy type 6. It aids clinicians in differentiating HSAN6 from other hereditary neuropathies and provides a basis for genetic counselling and family risk assessment.
- Test Code
- 4428
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are generally delivered within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. The patient's clinical history and family pedigree should be documented during a genetic counselling session before the test.
Method: Venepuncture, DNA sample submission, or FTA card spot
Laboratory Analysis
A small blood sample is collected in an EDTA tube, or one drop of blood is spotted on an FTA card. Extracted DNA may also be provided if already available.
Report Delivery
There are no post-test restrictions. The laboratory may contact the patient if a repeat sample or additional family samples are required for variant interpretation.
Timeline: Reports are generally delivered within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The test is intended to identify disease-causing variants in the DST gene to establish a molecular diagnosis of hereditary sensory and autonomic neuropathy type 6. It aids clinicians in differentiating HSAN6 from other hereditary neuropathies and provides a basis for genetic counselling and family risk assessment.
How to Prepare
- No special dietary preparation is required
- Carry the test requisition form and previous neurological or genetic reports
- Inform the laboratory about known family history of hereditary neuropathy
- Ensure sample tubes or FTA cards are labeled correctly before sending
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"The DST gene analysis should be ordered only after a detailed clinical evaluation by a neurologist or clinical geneticist. The result must be correlated with the patient's phenotype and family pedigree; genetic counselling before and after the test is essential for accurate interpretation and risk communication."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed blood sample
- Insufficient sample for DNA extraction
- Missing patient identification on the sample
- Sample leaking or not transported under appropriate temperature conditions
Understanding Your Results
Positive / Pathogenic or Likely Pathogenic
A disease-causing DST gene variant is identified. This is consistent with a molecular diagnosis of HSAN6 when clinical features match.
Negative
No pathogenic DST variant was identified. HSAN6 is less likely but may not be completely excluded if clinical suspicion remains high.
Variant of Uncertain Significance (VUS)
A DST gene change was identified, but its clinical significance is not yet established.
Consult a neurologist or clinical geneticist if you or a family member has progressive sensory loss, painless ulcers, delayed wound healing, abnormal sweating, balance problems, or a known family history of HSAN6. Genetic testing should follow a clinical evaluation and pre-test genetic counselling.
Limitations
- ⚠NGS may not detect all types of mutations, such as large structural rearrangements or deep intronic variants, depending on the assay
- ⚠A variant of uncertain significance may be reported; family segregation studies and further evaluation may be required
- ⚠A negative result does not completely exclude inherited neuropathy because another gene may be responsible
- ⚠This test is not a substitute for clinical diagnosis; interpretation by a clinical geneticist is required
Risks & Considerations
- ●Physical risks from blood collection are low; there may be mild bruising or bleeding at the puncture site
- ●The genetic result may have psychological or emotional implications for the patient and family
- ●A variant of uncertain significance may create uncertainty and may require additional testing
Interfering Factors
- ●Poor DNA quality or insufficient DNA quantity
- ●Recent allogeneic blood transfusion or bone marrow transplant may affect germline genetic testing
- ●Variants in deep intronic or regulatory regions may not be covered by the NGS assay
- ●Sample contamination or sample mix-up during collection
Compare With Similar Tests
| Test | DST Gene Neuropathy, hereditary sensory and autonomic type 6 NGS Genetic Test | Targeted DST single-gene sequencing | Hereditary neuropathy NGS panel |
|---|---|---|---|
| Comparison | DST Gene Neuropathy, hereditary sensory and autonomic type 6 NGS Genetic Test |
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