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DNA Labs India

FIP1L1-PGDFRA Gene Rearrangement Detection Test

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FIP1L1-PGDFRA Gene Rearrangement Detection Test

Short Name: FIP1L1-PGDFRA Test

Also known as: FIP1L1-PDGFRα Fusion Gene Test, FIP1L1-PDGFRα Rearrangement Detection, Hypereosinophilic Syndrome Genetic Test

FIP1L1-PGDFRA Gene Rearrangement Detection Test test available at DNA Labs India for ₹10,500. Uses PCR on Whole Blood or Bone Marrow samples. Results in Results are typically available within 12 days from sample receipt.. Free home collection in 300+ cities across India.

PCR-based Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect the FIP1L1-PGDFRA gene rearrangement to confirm diagnosis of hypereosinophilic syndrome (HES) and guide treatment decisions.

Test Code
559
Price
₹10,500
Sample Type
Whole Blood or Bone Marrow
Result Time
Results are typically available within 12 days from sample receipt.
Fasting Required
No
Method
PCR
Step 1

Sample Collection

Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. No specific fasting required.

Method: Venipuncture or Bone Marrow Aspiration

Step 2

Laboratory Analysis

Blood draw from vein or bone marrow aspiration under sterile conditions.

Step 3

Report Delivery

Sample shipped refrigerated to laboratory; do not freeze.

Timeline: Results are typically available within 12 days from sample receipt.

Patient Instructions

1
Before the Test:Ensure the Genomics Clinical Information Requisition Form (Form 20) is filled and signed. No fasting is required, but follow any instructions from your healthcare provider.
2
During the Test:A blood sample will be drawn from your vein, or in some cases, a bone marrow aspiration may be performed. The procedure is quick and minimally invasive.
3
After the Test:Apply pressure to the puncture site to prevent bruising. Results will be available in 12 days via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of this test is to detect the FIP1L1-PGDFRA gene rearrangement to confirm diagnosis of hypereosinophilic syndrome (HES) and guide treatment decisions.

How to Prepare

  • Complete and sign the Genomics Clinical Information Requisition Form (Form 20).
  • Collect 4 mL (2 mL min.) whole blood or bone marrow in a Lavender Top (EDTA) tube.
  • Label the tube correctly with patient details.
  • Ship the sample refrigerated (2-8°C); do not freeze.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is essential for identifying the FIP1L1-PGDFRA fusion, which guides targeted therapy in hypereosinophilic syndrome and related disorders."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood or Bone Marrow
Sample Volume4 mL (2 mL min.)
ContainerLavender Top (EDTA) tube
Collection MethodVenipuncture or Bone Marrow Aspiration

Sample Stability

Room Temperature: Up to 6 hours
Refrigerator (2-8°C): Up to 72 hours
Frozen: Not applicable
Sample Rejection Criteria:
  • Sample hemolyzed, clotted, or insufficient volume
  • Incorrect sample type or container
  • Missing or incomplete requisition form

Understanding Your Results

Results indicate the presence or absence of the FIP1L1-PDGFRα fusion gene rearrangement, which is key for diagnosing a specific subtype of hypereosinophilic syndrome.
📊

Detected

Positive for FIP1L1-PDGFRα rearrangement, consistent with a FIP1L1-PDGFRα–associated hypereosinophilic syndrome. This may guide targeted therapy with tyrosine kinase inhibitors.

📊

Not Detected

Negative for the rearrangement. Other causes of hypereosinophilia should be investigated, and clinical correlation is advised.

⚠️ When to Consult a Doctor:

If experiencing symptoms like persistent fatigue, weight loss, or if blood tests show elevated eosinophils, consult a hematologist or genetic specialist for evaluation.

Limitations

  • ⚠This test only detects FIP1L1-PGDFRA rearrangement
  • ⚠Negative result does not rule out other causes of hypereosinophilia
  • ⚠Test may not be informative in all clinical contexts

Risks & Considerations

  • ●Minor bruising or soreness at the blood draw site
  • ●Rare risk of infection or bleeding
  • ●Bone marrow aspiration may involve slight discomfort

Interfering Factors

  • ●Improper sample storage or handling
  • ●Contaminated or hemolyzed sample
  • ●Insufficient sample volume

Frequently Asked Questions

What is the FIP1L1-PGDFRA Gene Rearrangement Detection Test?
It is a genetic test that detects the presence of the FIP1L1-PDGFR? fusion gene, which is associated with hypereosinophilic syndrome (HES), a rare blood disorder characterized by overproduction of eosinophils.
Who should consider this test?
Individuals experiencing symptoms such as fatigue, weight loss, shortness of breath, or with an elevated eosinophil count in blood tests, suspecting hypereosinophilic syndrome.
What are the symptoms of hypereosinophilic syndrome?
Common symptoms include persistent fatigue, weakness, unexplained weight loss, shortness of breath, chest pain, abdominal pain, recurring fever, and night sweats.
How is the test performed?
The test analyzes a blood or bone marrow sample using PCR (polymerase chain reaction) technology to identify the FIP1L1-PDGFR? gene rearrangement with high sensitivity and specificity.
What is the cost of the FIP1L1-PGDFRA Gene Rearrangement Detection Test?
The cost at DNA Labs India is INR 10500, which includes sample collection, laboratory analysis, and a detailed report.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across numerous cities in India for your convenience.
How long does it take to get results?
Results are typically available within 12 days from the sample receipt, delivered via online portal, email, or WhatsApp.
What does a positive result mean?
A positive result indicates the presence of the FIP1L1-PDGFR? rearrangement, confirming a subtype of HES that may be effectively treated with targeted tyrosine kinase inhibitor therapy such as imatinib.
What should I do before the test?
Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly filled and signed. No fasting is required, but follow any specific instructions from your doctor.
Are there any risks associated with the test?
The test involves a standard blood draw with minimal risks like minor bruising. Bone marrow aspiration, if needed, may involve slight discomfort and rare risks of infection or bleeding.
Is the test covered by insurance?
Coverage varies by insurance provider. It is generally not covered under government schemes like PMJAY or CGHS. Check with your private insurer for specific coverage details.
How can I book the test?
You can book online through the DNA Labs India website or contact them directly via phone or WhatsApp to schedule home collection or a walk-in visit at your nearest center.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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