FISH - Ewing Sarcoma (EWS) 22q12 (EWSR1) Rearrangement Test
Short Name: FISH EWSR1 Test
Also known as: EWSR1 Rearrangement FISH, Ewing Sarcoma Genetic Test
FISH - Ewing Sarcoma (EWS) 22q12 (EWSR1) Rearrangement Test test available at DNA Labs India for ₹8,500. Uses FISH on Formalin-fixed paraffin-embedded tissue samples. Results in 7-8 working days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
To detect EWSR1 gene rearrangements for confirming Ewing Sarcoma diagnosis and guiding treatment decisions.
- Test Code
- 579
- Price
- ₹8,500
- Sample Type
- Formalin-fixed paraffin-embedded tissue
- Result Time
- 7-8 working days
- Fasting Required
- No
- Method
- FISH
Sample Collection
Ensure the requisition form is filled and accompany the sample.
Method: Biopsy collection
Laboratory Analysis
Tissue biopsy collection performed by a healthcare professional.
Report Delivery
Store tissue in formalin and transport to lab at room temperature.
Timeline: 7-8 working days
Patient Instructions
About This Test
Who Should Get This Test
To detect EWSR1 gene rearrangements for confirming Ewing Sarcoma diagnosis and guiding treatment decisions.
How to Prepare
- Submit formalin-fixed paraffin-embedded tissue block.
- Tissue block must contain at least 10% tumor tissue.
- Ship at room temperature.
- Include completed Chromosome & FISH analysis Requisition Form (Form 17).
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This test is crucial for confirming Ewing Sarcoma diagnosis and guiding targeted therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor tissue
- Missing requisition form
- Improperly fixed tissue
Understanding Your Results
Positive
EWSR1 rearrangement detected, consistent with Ewing Sarcoma.
Negative
No EWSR1 rearrangement detected; Ewing Sarcoma less likely.
Consult an oncologist if the test is positive or if symptoms persist despite negative results.
Limitations
- ⚠Cannot detect all types of EWSR1 rearrangements
- ⚠May require confirmation with other methods
- ⚠FISH detects only specific translocations
Risks & Considerations
- ●Risks associated with biopsy procedure, such as infection or bleeding
Interfering Factors
- ●Poor quality tissue sample
- ●Insufficient tumor content
- ●DNA degradation
Compare With Similar Tests
| Test | FISH - Ewing Sarcoma (EWS) 22q12 (EWSR1) Rearrangement Test | Immunohistochemistry | RT-PCR |
|---|---|---|---|
| Comparison | FISH - Ewing Sarcoma (EWS) 22q12 (EWSR1) Rearrangement Test | IHC is less specific; FISH provides genetic confirmation. | RT-PCR can detect fusion transcripts but requires fresh tissue. |
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