FISH - Synovial Sarcoma (SS18 / SYT) 18q11.2 Gene Rearrangement Test
Short Name: FISH SS18/SYT Rearrangement Test
Also known as: FISH for Synovial Sarcoma, SS18/SYT Gene Rearrangement Test, Synovial Sarcoma FISH Test
FISH - Synovial Sarcoma (SS18 / SYT) 18q11.2 Gene Rearrangement Test test available at DNA Labs India for ₹12,000. Uses Fluorescence In Situ Hybridization (FISH) on Formalin fixed paraffin embedded tissue block samples. Results in 4 working days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To detect the SS18/SYT gene rearrangement associated with synovial sarcoma, providing a definitive diagnosis to guide appropriate treatment and management.
- Test Code
- 603
- Price
- ₹12,000
- Sample Type
- Formalin fixed paraffin embedded tissue block
- Result Time
- 4 working days
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
Schedule a biopsy procedure with your healthcare provider. Inform them of any medications or health conditions.
Method: Biopsy
Laboratory Analysis
The biopsy is performed under local or general anesthesia, depending on the tumor location. A tissue sample is taken from the suspected area.
Report Delivery
The tissue block is placed in formalin and shipped at room temperature to the lab with the completed requisition form.
Timeline: 4 working days
Patient Instructions
About This Test
Who Should Get This Test
To detect the SS18/SYT gene rearrangement associated with synovial sarcoma, providing a definitive diagnosis to guide appropriate treatment and management.
How to Prepare
- Submit a formalin fixed paraffin embedded tissue block.
- Ship at room temperature.
- Ensure the tissue block contains at least 10% tumor tissue.
- Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is crucial for confirming synovial sarcoma, a rare soft tissue cancer, and guiding targeted treatment decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor content in the tissue block
- Improperly filled or missing requisition form
- Contaminated or degraded sample
- Sample not shipped at room temperature
Understanding Your Results
Positive
SS18/SYT gene rearrangement detected, consistent with synovial sarcoma. This confirms the diagnosis and guides treatment planning.
Negative
No SS18/SYT rearrangement detected. Synovial sarcoma is unlikely, but other diagnoses should be considered. Further testing may be needed.
If you experience symptoms such as a persistent lump, swelling, numbness, tingling, or difficulty moving a limb, consult an oncologist immediately for evaluation and possible testing.
Limitations
- ⚠Only detects SS18/SYT gene rearrangement; may not identify rare variants or other genetic abnormalities
- ⚠Requires adequate tumor tissue for accurate results
- ⚠Results may be influenced by sample preparation and interpretation expertise
- ⚠Not used for screening or monitoring of other cancer types
Risks & Considerations
- ●Biopsy-related risks: infection, bleeding, or pain at the biopsy site
- ●Potential for false-negative or false-positive results
- ●Anxiety while waiting for results
Interfering Factors
- ●Poor tissue sample quality or insufficient fixation
- ●Low tumor content in the biopsy specimen (less than 10%)
- ●Improper handling or shipping conditions
- ●Contamination of the sample
Frequently Asked Questions
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