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FKBP10 Gene Osteogenesis imperfecta type 11 NGS Genetic Test

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FKBP10 Gene Osteogenesis imperfecta type 11 NGS Genetic Test

Short Name: FKBP10 OI Type 11 NGS Test

Also known as: Osteogenesis Imperfecta Type 11, Brittle Bone Disease Type 11

FKBP10 Gene Osteogenesis imperfecta type 11 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose Osteogenesis Imperfecta Type 11 by detecting mutations in the FKBP10 gene using NGS technology, enabling accurate medical management and genetic counseling.

Test Code
5087
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with OI type 11.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard blood draw procedure by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising; keep the area clean.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling to discuss test implications.
2
During the Test:A blood sample is collected; the procedure is quick and minimally invasive.
3
After the Test:Wait for results in 3 to 4 weeks; follow up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

To diagnose Osteogenesis Imperfecta Type 11 by detecting mutations in the FKBP10 gene using NGS technology, enabling accurate medical management and genetic counseling.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment for blood collection
  • Label samples correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for OI type 11 is crucial for accurate diagnosis and management. Consult a genetic counselor for personalized advice and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture
Sample Rejection Criteria:
  • Hemolyzed or insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Test results indicate the presence or absence of pathogenic variants in the FKBP10 gene. A positive result confirms OI type 11, while a negative result may require further clinical evaluation.
📊

Positive for pathogenic variant

Confirms diagnosis of Osteogenesis Imperfecta Type 11; genetic counseling recommended.

📊

Negative for pathogenic variant

No mutations detected in FKBP10 gene; consider other genetic or clinical causes.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

If you experience frequent fractures, bone pain, or have a family history of OI, consult a doctor or genetic counselor for evaluation and testing.

Limitations

  • ⚠May not detect all types of mutations in the FKBP10 gene
  • ⚠Results require interpretation by a genetic specialist

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality

Frequently Asked Questions

What is Osteogenesis Imperfecta Type 11?
OI type 11 is a rare genetic disorder caused by mutations in the FKBP10 gene, leading to brittle bones and connective tissue issues due to defective collagen production.
What causes OI type 11?
It is caused by mutations in the FKBP10 gene, which impairs the production of FKBP65 protein essential for collagen formation.
What are the symptoms of OI type 11?
Symptoms include frequent fractures, short stature, weak muscles, bowed limbs, and joint laxity, varying in severity.
How is OI type 11 diagnosed?
Diagnosis involves clinical evaluation, family history assessment, and genetic testing such as NGS to detect FKBP10 gene mutations.
What is the FKBP10 gene?
The FKBP10 gene provides instructions for making the FKBP65 protein, crucial for collagen molecule formation and bone strength.
What is NGS genetic testing?
Next-Generation Sequencing (NGS) is a advanced technology that analyzes multiple genes simultaneously to identify genetic mutations accurately.
How much does the FKBP10 Gene OI Type 11 NGS Test cost in India?
The test costs INR 20000 at DNA Labs India, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What should I do before the test?
Provide your clinical history and undergo a genetic counseling session to prepare for the test and understand its implications.
Are there any risks associated with the test?
The test involves a standard blood draw with minimal risks like bruising or discomfort; serious complications are rare.
How can I interpret the test results?
Results should be interpreted by a genetic specialist or counselor; a positive result confirms OI type 11, while negative may require further evaluation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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