Fungal Genome Sequencing and Reference Based Analysis Test
Short Name: Fungal Genome Sequencing
Also known as: Fungal Whole Genome Sequencing, Fungal WGS, Reference-Based Fungal Analysis
Fungal Genome Sequencing and Reference Based Analysis Test test available at DNA Labs India for ₹40,000. Uses Next-Generation Sequencing (NGS), Reference-based bioinformatics analysis on Extracted DNA samples. Results in Results are typically available within 8 weeks after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of fungal genome sequencing and reference-based analysis is to provide a definitive molecular diagnosis of fungal infections by identifying the exact species and genetic characteristics of the pathogen. This test helps in detecting mutations associated with antifungal drug resistance, guiding the selection of appropriate antifungal therapy, and monitoring treatment response. It is also useful for epidemiological studies and outbreak investigations by enabling strain-level discrimination. For patients with persistent or severe infections, this genomic approach offers a precise and actionable diagnosis that can improve clinical outcomes.
- Test Code
- 6342
- CPT Code
- 81479
- ICD Code
- B49
- Price
- ₹40,000
- Sample Type
- Extracted DNA
- Result Time
- Results are typically available within 8 weeks after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Reference-based bioinformatics analysis
Sample Collection
No special preparation is required. However, if the sample is from a culture, ensure it is pure and viable. For direct specimens, follow the collection instructions provided by the laboratory.
Method: DNA extraction from clinical specimen (e.g., tissue, fluid, culture)
Laboratory Analysis
The sample (extracted DNA) is collected in a sterile tube. If a clinical specimen is required, it will be collected by a trained professional using appropriate sterile techniques.
Report Delivery
The sample should be transported to the laboratory as per instructions. No specific post-collection care is needed for the patient.
Timeline: Results are typically available within 8 weeks after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of fungal genome sequencing and reference-based analysis is to provide a definitive molecular diagnosis of fungal infections by identifying the exact species and genetic characteristics of the pathogen. This test helps in detecting mutations associated with antifungal drug resistance, guiding the selection of appropriate antifungal therapy, and monitoring treatment response. It is also useful for epidemiological studies and outbreak investigations by enabling strain-level discrimination. For patients with persistent or severe infections, this genomic approach offers a precise and actionable diagnosis that can improve clinical outcomes.
How to Prepare
- Use a sterile, DNase-free microcentrifuge tube
- Label the tube with patient ID and date
- Store at 2-8°C if transport is within 24 hours; otherwise freeze at -20°C
- Avoid repeated freeze-thaw cycles
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Fungal genome sequencing is a powerful tool for identifying rare and drug-resistant fungal pathogens. This test helps tailor antifungal therapy, improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient DNA quantity (<10 ng)
- Degraded DNA (fragmentation)
- Improper labeling
- Sample in non-sterile container
Understanding Your Results
Species identified as susceptible to common antifungals
Standard antifungal therapy may be effective
Resistance mutation detected (e.g., CYP51A in Aspergillus)
Alternative antifungal agents should be considered
Novel variant of unknown significance
Further functional studies may be needed; consult infectious disease specialist
No resistance mutations detected
Likely susceptible to first-line antifungals
Consult your physician if you have persistent symptoms of fungal infection, if the infection is not responding to treatment, or if you are immunocompromised and suspect a fungal infection. The results of this test should be discussed with your healthcare provider for appropriate management.
Limitations
- ⚠Reference-based analysis may not detect novel mutations not present in the reference genome
- ⚠Requires sufficient fungal DNA; culture may be needed if direct specimen has low fungal load
- ⚠Interpretation depends on the availability of a closely related reference genome
- ⚠Not a substitute for histopathology or culture in all cases
Risks & Considerations
- ●No significant risks associated with sample collection
- ●Possible bruising or infection at the collection site (rare)
Interfering Factors
- ●Poor quality or degraded DNA
- ●Contamination with host or other microbial DNA
- ●Insufficient fungal DNA concentration
- ●Incomplete reference genome for rare species
Compare With Similar Tests
| Test | Fungal Genome Sequencing and Reference Based Analysis | |||
|---|---|---|---|---|
| Comparison | Fungal Genome Sequencing and Reference Based Analysis |
Frequently Asked Questions
What is fungal genome sequencing?
How is reference-based analysis different from whole-genome sequencing?
What sample is needed for this test?
Is fasting required before the test?
How long does it take to get results?
Can this test detect all types of fungal infections?
Does this test help in choosing antifungal medication?
Is home sample collection available?
What is the cost of the test?
Are there any risks associated with the test?
Can this test be done on a blood sample?
How should the sample be transported?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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