Histoplasma Quantitative Test
Short Name: Histoplasma Quantitative
Also known as: Histoplasma PCR Quantitative, Histoplasma DNA Quantification
Histoplasma Quantitative Test test available at DNA Labs India for ₹9,860. Uses Real Time PCR on Blood, fresh tissue biopsy, skin biopsy, respiratory secretions, bone marrow, other tissue specimens samples. Results in Reports are available on the 4th working day. Email reports within 48 hours, phone consultation within 36 hours.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Kothari Ramesh Shantilal
Consultant Microbiologist · Reg: 27670
Last reviewed: September 7, 2026
Overview
The purpose of the Histoplasma Quantitative Test is to detect the presence of Histoplasma capsulatum DNA in clinical specimens and quantify the fungal burden. This aids in confirming the diagnosis of histoplasmosis, especially in cases where culture or serology is inconclusive. Quantitative results help clinicians assess the severity of infection, monitor the efficacy of antifungal therapy, and make informed decisions regarding treatment duration and adjustments. The test is particularly valuable in immunocompromised patients, such as those with HIV/AIDS, organ transplant recipients, or those on immunosuppressive therapy, where early detection and monitoring are critical.
- Test Code
- 6157
- CPT Code
- 87798
- ICD Code
- B39.9
- Price
- ₹9,860
- Sample Type
- Blood, fresh tissue biopsy, skin biopsy, respiratory secretions, bone marrow, other tissue specimens
- Result Time
- Reports are available on the 4th working day. Email reports within 48 hours, phone consultation within 36 hours.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
No special preparation is required. However, patients must sign a consent document and provide relevant clinical history.
Method: Venipuncture or biopsy
Laboratory Analysis
Blood sample is drawn by venipuncture; tissue biopsy is performed by a healthcare professional. Ensure sterile conditions.
Report Delivery
No specific precautions. Patients can resume normal activities immediately.
Timeline: Reports are available on the 4th working day. Email reports within 48 hours, phone consultation within 36 hours.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Histoplasma Quantitative Test is to detect the presence of Histoplasma capsulatum DNA in clinical specimens and quantify the fungal burden. This aids in confirming the diagnosis of histoplasmosis, especially in cases where culture or serology is inconclusive. Quantitative results help clinicians assess the severity of infection, monitor the efficacy of antifungal therapy, and make informed decisions regarding treatment duration and adjustments. The test is particularly valuable in immunocompromised patients, such as those with HIV/AIDS, organ transplant recipients, or those on immunosuppressive therapy, where early detection and monitoring are critical.
How to Prepare
- For blood: Collect in EDTA tube, mix gently, and transport at 2-8°C.
- For tissue: Place in sterile container with appropriate transport medium, keep at 2-8°C.
- Label the sample with patient identification and collection date/time.
- Ship to laboratory immediately; do not freeze.
Doctor's Notes
Reviewed by Dr Kothari Ramesh Shantilal — MBBS, MD (Microbiology) · Reg. No. 27670
"Quantitative Histoplasma PCR is essential for monitoring fungal load in immunocompromised patients and guiding antifungal therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood samples
- Insufficient sample volume
- Improperly labeled samples
- Samples received after prolonged delay without proper storage
Understanding Your Results
No Histoplasma DNA detected
No evidence of histoplasmosis; however, clinical correlation is advised.
Low copy number
Active infection with low fungal burden; may require treatment and monitoring.
High copy number
High fungal burden, likely severe or disseminated infection; urgent treatment needed.
Consult your doctor if you have symptoms of histoplasmosis, especially if you are immunocompromised or have been exposed to bird/bat droppings. Early diagnosis and treatment are essential.
Limitations
- ⚠A negative result does not completely rule out histoplasmosis, especially in early or localized disease
- ⚠Quantitative results should be interpreted in conjunction with clinical findings and other diagnostic tests
- ⚠Cross-reactivity with other dimorphic fungi is rare but possible
- ⚠Test may not distinguish between active and past infection in some cases
Risks & Considerations
- ●Minimal risk of bleeding or bruising at the blood draw site
- ●Rare risk of infection at biopsy site
- ●No significant risks associated with the test itself
Interfering Factors
- ●Recent antifungal therapy may reduce fungal DNA levels, leading to false-negative results
- ●Improper sample collection or storage may degrade DNA
- ●Contamination during sample processing can cause false positives
- ●Low fungal load in early infection may be below detection limit
Compare With Similar Tests
| Test | Histoplasma Quantitative Test | Histoplasma Antibody Test | Histoplasma Antigen Test | Fungal Culture |
|---|---|---|---|---|
| Comparison | Histoplasma Quantitative Test |
Frequently Asked Questions
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