HLA - DP Typing Test
Short Name: HLA-DP Typing
Also known as: HLA-DP Locus Typing, HLA Class II DP Typing, Human Leukocyte Antigen DP Typing, DPA1 DPB1 Typing, HLA-DP Transplant Matching Test
HLA - DP Typing Test test available at DNA Labs India for ₹7,020. Uses Reverse SSOP - Luminex on Whole Blood samples. Results in Results are typically available within 10-12 working days from the date of sample receipt at the laboratory. Reports are delivered via the online portal, email, or WhatsApp. In urgent transplant situations, the laboratory may be contacted for expedited processing options.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the HLA-DP Typing Test is to identify the specific DPA1 and DPB1 alleles of the donor and recipient prior to transplantation. HLA-DP is one of the class II HLA loci, and its matching plays an important role in determining transplant compatibility. The test is used for bone marrow transplantation (HSCT), cord blood banking, donor registry matching, and solid organ transplants including kidney, liver, heart, and lung transplantation. Identifying mismatches at the HLA-DP locus helps transplant teams assess the immunological risk and plan conditioning regimens, immunosuppressive therapy, and post-transplant monitoring accordingly. This assay is not a diagnostic test for any specific disease but is a compatibility and risk-assessment tool essential in the transplant medicine workflow.
- Test Code
- 789
- CPT Code
- 81376
- ICD Code
- Z00.89
- Price
- ₹7,020
- Sample Type
- Whole Blood
- Result Time
- Results are typically available within 10-12 working days from the date of sample receipt at the laboratory. Reports are delivered via the online portal, email, or WhatsApp. In urgent transplant situations, the laboratory may be contacted for expedited processing options.
- Fasting Required
- No
- Method
- Reverse SSOP - Luminex
Sample Collection
Ensure a doctor's prescription is available on official letterhead with one photograph each of the recipient and donor, duly stamped. The Consent Form for HLA Typing for Solid Organ Transplant (Form 33) must be signed by the patient or legal guardian. No fasting is required. Inform the phlebotomist of any recent blood transfusions.
Method: Venipuncture
Laboratory Analysis
A venipuncture will be performed to collect 4 mL of whole blood in a Lavender Top (EDTA) tube or 6 mL in a Yellow Top (ACD) tube. The collection is a standard blood draw procedure with minimal discomfort. The sample will be labelled with patient and donor identifiers and documentation will be verified at the time of collection.
Report Delivery
Apply pressure to the venipuncture site with cotton or gauze for 3-5 minutes. Avoid heavy lifting with the arm used for blood draw for the rest of the day. The blood sample will be shipped refrigerated to the laboratory. Results are available within 10-12 working days and will be delivered via online portal, email, or WhatsApp.
Timeline: Results are typically available within 10-12 working days from the date of sample receipt at the laboratory. Reports are delivered via the online portal, email, or WhatsApp. In urgent transplant situations, the laboratory may be contacted for expedited processing options.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the HLA-DP Typing Test is to identify the specific DPA1 and DPB1 alleles of the donor and recipient prior to transplantation. HLA-DP is one of the class II HLA loci, and its matching plays an important role in determining transplant compatibility. The test is used for bone marrow transplantation (HSCT), cord blood banking, donor registry matching, and solid organ transplants including kidney, liver, heart, and lung transplantation. Identifying mismatches at the HLA-DP locus helps transplant teams assess the immunological risk and plan conditioning regimens, immunosuppressive therapy, and post-transplant monitoring accordingly. This assay is not a diagnostic test for any specific disease but is a compatibility and risk-assessment tool essential in the transplant medicine workflow.
How to Prepare
- Doctor's prescription on letterhead with 1 photograph each of recipient and donor, duly stamped, is mandatory
- Signed Consent Form for HLA Typing for Solid Organ Transplant (Form 33) is mandatory
- Sample: 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube
- Ship refrigerated. DO NOT FREEZE.
- Label the sample clearly with patient name, donor name, and unique identifiers
- Inform the lab of any recent blood transfusions or stem cell transplants
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"HLA-DP typing is a critical component of pre-transplant workup. Matching at the HLA-DP locus between donor and recipient significantly reduces the risk of graft-versus-host disease in bone marrow transplantation and lowers the incidence of acute and chronic rejection in solid organ transplants. I recommend this test for all potential transplant recipients and their donors to ensure optimal compatibility and improved transplant outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received frozen
- Sample collected in incorrect tube type (not EDTA or ACD)
- Insufficient sample volume (less than 3 mL)
- Missing or incomplete doctor's prescription or photographs
- Missing signed consent form (Form 33)
- Haemolyzed, clotted, or contaminated sample
- Sample received at room temperature
- Sample older than 96 hours from collection
Understanding Your Results
Donor and recipient share identical DPA1 and DPB1 alleles. This is the ideal scenario for transplant compatibility at the DP locus and is associated with lower immunological risk.
Action: Proceed with transplant evaluation in conjunction with full HLA typing results across all loci.
Result type: Full Match at HLA-DP
Donor and recipient differ at one allele (DPA1 or DPB1). This represents a partial mismatch and may increase the risk of GvHD or graft rejection to some degree.
Action: Discuss with transplant team. Additional immunosuppressive strategies may be considered. Clinical correlation with other HLA loci results is essential.
Result type: Partial Mismatch at HLA-DP
Donor and recipient differ at both DPA1 and DPB1 alleles. This carries a higher immunological risk for transplant-related complications including GvHD and graft failure.
Action: Transplant team should weigh the risks and benefits. Consider alternative donors if available. Enhanced monitoring and immunosuppression protocols may be required.
Result type: Full Mismatch at HLA-DP
The typing could not definitively resolve all alleles, or a rare/novel allele was detected that does not match known database entries.
Action: Additional high-resolution confirmatory testing may be recommended. Consult the immunogenetics laboratory for further analysis.
Result type: Inconclusive or Novel Allele Detected
Consult your transplant physician, nephrologist, hematologist, or transplant surgeon if you are being evaluated for a bone marrow transplant, stem cell transplant, or solid organ transplant. Additionally, consult your doctor if you have been identified as a potential donor in a donor registry, if you are planning cord blood banking, or if you have symptoms of transplant-related complications such as skin rashes, diarrhoea, jaundice, or declining organ function after a transplant. This test is part of a broader pre-transplant workup and results must be reviewed alongside complete HLA typing and clinical evaluation.
Limitations
- ⚠This test identifies HLA-DP alleles only; it does not provide typing for HLA-A, HLA-B, HLA-C, HLA-DR, or HLA-DQ loci
- ⚠Results are for compatibility assessment and are not diagnostic of any disease
- ⚠Rare or novel alleles may require additional confirmation testing
- ⚠Test accuracy may be reduced in patients who have recently undergone blood transfusion or stem cell transplant
- ⚠Clinical interpretation must be done by a transplant specialist in the context of overall HLA typing results
Risks & Considerations
- ●Minor bruising or discomfort at the venipuncture site
- ●Rare risk of slight bleeding in individuals with coagulation disorders
- ●Very rare risk of infection at the puncture site
- ●No significant health risks associated with the test itself
Interfering Factors
- ●Recent blood transfusion may affect typing accuracy due to circulating donor DNA
- ●Improper sample storage (freezing is not permitted for this test)
- ●Contaminated or hemolyzed blood sample
- ●Use of incorrect anticoagulant tube (only EDTA or ACD tubes are accepted)
- ●Missing or incomplete mandatory documentation (doctor's prescription, photographs, consent form)
Compare With Similar Tests
| Test | HLA - DP Typing Test | HLA - A, B Typing Test | HLA - DR Typing Test | HLA - DQ Typing Test | HLA - C Typing Test | Panel Reactive Antibody (PRA) Test |
|---|---|---|---|---|---|---|
| Comparison | HLA - DP Typing Test | Identifies HLA Class I alleles at A and B loci. HLA-DP typing covers Class II DP locus. Both are needed for comprehensive transplant matching. | Identifies HLA Class II DR locus alleles. HLA-DP and HLA-DR are both Class II loci but encode different antigen-presenting molecules. Both are critical in transplant compatibility. | Identifies HLA Class II DQ locus alleles. DQ and DP are adjacent Class II loci. Together with DR typing, they provide complete Class II HLA characterization. | Identifies HLA Class I C locus alleles. HLA-C is important for NK cell-mediated allorecognition in transplantation. HLA-DP focuses on T-cell-mediated Class II responses. | PRA measures pre-formed antibodies against HLA antigens. While HLA-DP typing identifies alleles, PRA assesses sensitization status. Both are complementary in transplant evaluation. |
Frequently Asked Questions
What is the HLA-DP Typing Test?
Why is HLA-DP typing important for transplantation?
What sample is required for the HLA-DP Typing Test?
What documents are mandatory for this test?
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What is the cost of the HLA-DP Typing Test at DNA Labs India?
Is fasting required before the HLA-DP Typing Test?
What is the difference between HLA-DP typing and HLA-DR typing?
Can the HLA-DP Typing Test diagnose autoimmune diseases?
What testing method is used for HLA-DP typing at DNA Labs India?
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